Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme

Sabatini, Serena; Martyr, Anthony; Hunt, Anna; Gamble, Laura D.; Matthews, Fiona E.; Thom, Jeanette M.; Jones, Roy W.; Allan, Louise; Knapp, Martin; Victor, Christina; Pentecost, Claire; Rusted, Jennifer M.; Morris, Robin G.; Clare, Linda

doi:10.1186/s12877-023-04601-x

All Outputs (4)

Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme (2024)
Journal Article
Martyr, A., Gamble, L. D., Hunt, A., Quinn, C., Morris, R. G., Henderson, C., Allan, L., Opdebeeck, C., Charlwood, C., Jones, R. W., Pentecost, C., Kopelman, M. D., Thom, J. M., Matthews, F. E., & Clare, L. (2024). Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme. BMC medicine, 22(1), Article 265. https://doi.org/10.1186/s12916-024-03492-y

Background: People with different types of dementia may have distinct symptoms and experiences that affect their quality of life. This study investigated whether quality of life varied across types of dementia and over time. Methods: The participants... Read More about Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme.

The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction (2024)
Journal Article
Almansouri, T., Waller, R., Wharton, S. B., Heath, P. R., Matthews, F. E., Brayne, C., van Eeden, F., & Simpson, J. E. (2024). The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction. International Journal of Molecular Sciences, 25(8), Article 4445. https://doi.org/10.3390/ijms25084445

Age-associated deep-subcortical white matter lesions (DSCLs) are an independent risk factor for dementia, displaying high levels of CD68+ microglia. This study aimed to characterize the transcriptomic profile of microglia in DSCLs and surrounding rad... Read More about The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction.

Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F. E., Thom, J. M., …Clare, L. (2024). Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24(1), Article 171. https://doi.org/10.1186/s12877-024-04707-w

Objectives: Longitudinal evidence documenting health conditions in spousal caregivers of people with dementia and whether these influence caregivers’ outcomes is scarce. This study explores type and number of health conditions over two years in careg... Read More about Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme.

Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F. E., Thom, J. M., Jones, R. W., Allan, L., Knapp, M., Victor, C., Pentecost, C., Rusted, J. M., Morris, R. G., & Clare, L. (2024). Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24(1), Article 23. https://doi.org/10.1186/s12877-023-04601-x

Background: Most people with dementia have multiple health conditions. This study explores (1) number and type of health condition(s) in people with dementia overall and in relation to age, sex, dementia type, and cognition; (2) change in number of h... Read More about Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme.