All Outputs (2)

The role of glucosinolates from cruciferous vegetables (Brassicaceae) in gastrointestinal cancers: from prevention to therapeutics (2022)
Journal Article
Melim, C., Lauro, M., Pires, I. M., Oliveira, P., & Cabral, C. (2022). The role of glucosinolates from cruciferous vegetables (Brassicaceae) in gastrointestinal cancers: from prevention to therapeutics. Pharmaceutics, 14(1), Article 190. https://doi.org/10.3390/pharmaceutics14010190

The gastrointestinal (GI) tract is composed of rapidly renewing cells, which increase the likelihood of cancer. Colorectal cancer is one of the most frequently diagnosed GI cancers and currently stands in second place regarding cancer-related mortali... Read More about The role of glucosinolates from cruciferous vegetables (Brassicaceae) in gastrointestinal cancers: from prevention to therapeutics.

Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1 (2010)
Journal Article
Pires, I. M., Bencokova, Z., Hammond, E. M., & McGurk, C. (2010). Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1. Cell cycle, 9(13), 2502-2507. https://doi.org/10.4161/cc.9.13.12059

Severe hypoxia has been demonstrated to induce a replication arrest which is associated with decreased levels of nucleotides. Chk1 is rapidly phosphorylated in response to severe hypoxia and in turn deactivates TLK1 through phosphorylation. Loss of C... Read More about Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1.