All Outputs (20)

Addressing delays to treatment in patients with chronic limb-threatening ischaemia (2023)
Thesis
Birmpili, P. Addressing delays to treatment in patients with chronic limb-threatening ischaemia. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4371299

Patients with CLTI often face long delays from referral to the vascular surgery service and hospital admission to revascularisation, and there is limited evidence on the effect of these delays on patient outcomes. This thesis aims to identify factors... Read More about Addressing delays to treatment in patients with chronic limb-threatening ischaemia.

Mechanochemical ablation in the treatment of superficial venous incompetence (2021)
Thesis
Mohamed, A. (2021). Mechanochemical ablation in the treatment of superficial venous incompetence. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4223528

Background
The routine management of venous incompetence has undergone considerable changes in the last two decades led by the introduction of minimally invasive endovenous techniques. At the heart of these changes has been a drive to offer patients... Read More about Mechanochemical ablation in the treatment of superficial venous incompetence.

Alternative exercise programmes for the treatment of intermittent claudication - from unsupervised home-based walking to supervised high-intensity interval cycling (2021)
Thesis
Pymer, S. (2021). Alternative exercise programmes for the treatment of intermittent claudication - from unsupervised home-based walking to supervised high-intensity interval cycling. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4223166

Supervised exercise programmes (SEP) for intermittent claudication (IC) suffer from low provision and uptake rates. As such, alternative interventions should be explored, such as home-based exercise programmes (HEP) and high-intensity interval traini... Read More about Alternative exercise programmes for the treatment of intermittent claudication - from unsupervised home-based walking to supervised high-intensity interval cycling.

Long-term Clinical and Cost-effectiveness of Early Endovenous Ablation in Venous Ulceration: A Randomized Clinical Trial (2020)
Journal Article
Gohel, M. S., Mora, MSc, J., Szigeti, M., Epstein, D. M., Heatley, F., Bradbury, A., …Davies, A. H. (in press). Long-term Clinical and Cost-effectiveness of Early Endovenous Ablation in Venous Ulceration: A Randomized Clinical Trial. JAMA Surgery, https://doi.org/10.1001/jamasurg.2020.3845

Importance One-year outcomes from the Early Venous Reflux Ablation (EVRA) randomized trial showed accelerated venous leg ulcer healing and greater ulcer-free time for participants who are treated with early endovenous ablation of lower extremity sup... Read More about Long-term Clinical and Cost-effectiveness of Early Endovenous Ablation in Venous Ulceration: A Randomized Clinical Trial.

Investigating the effectiveness of dialkylcarbamoylchloride-coated wound dressings in the prevention of surgical site infection (2019)
Thesis
Totty, J. P. (2019). Investigating the effectiveness of dialkylcarbamoylchloride-coated wound dressings in the prevention of surgical site infection. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4222026

Background: Surgical site infection (SSI) is the second most common healthcare acquired infection and may complicate between 5 and 30% of all surgical procedures. Avoidance of antibiotic or antimicrobial agents is important to future prevention strat... Read More about Investigating the effectiveness of dialkylcarbamoylchloride-coated wound dressings in the prevention of surgical site infection.

Surgical site infection following major lower limb amputation : analysing the clinical effectiveness of antibiotic prophylaxis duration and skin preparation (2017)
Thesis
Souroullas, P. (2017). Surgical site infection following major lower limb amputation : analysing the clinical effectiveness of antibiotic prophylaxis duration and skin preparation. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4221143

Background: Major LLA remains a common operation in the United Kingdom with ⁓5000 procedures performed yearly. Amputations are described as ‘clean surgery’ and SSIs in this patient cohort have been previously under-reported. The true incidence lies b... Read More about Surgical site infection following major lower limb amputation : analysing the clinical effectiveness of antibiotic prophylaxis duration and skin preparation.

The role of peroneal nerve electrical neuromuscular stimulation in the augmentation of lower limb circulatory physiology in lower limb arterial and venous disease (2015)
Thesis
Barnes, R. M. (2015). The role of peroneal nerve electrical neuromuscular stimulation in the augmentation of lower limb circulatory physiology in lower limb arterial and venous disease. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4218711

Introduction:
Studies in healthy volunteers have demonstrated that peroneal nerve stimulation augments blood flow. The studies described within this thesis aimed to establish whether use of the geko™ neuromuscular stimulation device was effective a... Read More about The role of peroneal nerve electrical neuromuscular stimulation in the augmentation of lower limb circulatory physiology in lower limb arterial and venous disease.

The ETTAA study protocol: A UK-wide observational study of 'Effective treatments for thoracic aortic aneurysm' (2015)
Journal Article
Sastry, P., Hughes, V., Hayes, P., Vallabhaneni, S. R., Sharples, L., Thompson, M., …on behalf of the ETTAA collaborators. (2015). The ETTAA study protocol: A UK-wide observational study of 'Effective treatments for thoracic aortic aneurysm'. BMJ open, 5(6), e008147-e008147. https://doi.org/10.1136/bmjopen-2015-008147

© 2015 BMJ Open. Introduction: Chronic thoracic aortic aneurysm (CTAA) affecting the arch or descending aorta is an indolent but life-threatening condition with a rising prevalence as the UK population ages. Treatment may be in the form of open surgi... Read More about The ETTAA study protocol: A UK-wide observational study of 'Effective treatments for thoracic aortic aneurysm'.

The effect of aortic morphology on peri-operative mortality of ruptured abdominal aortic aneurysm (2015)
Journal Article
IMPROVE Trial Investigators. (2015). The effect of aortic morphology on peri-operative mortality of ruptured abdominal aortic aneurysm. European Heart Journal, 36(21), 1328-1334. https://doi.org/10.1093/eurheartj/ehu521

Aims To investigate whether aneurysm shape and extent, which indicate whether a patient with ruptured abdominal aortic aneurysm (rAAA) is eligible for endovascular repair (EVAR), influence the outcome of both EVAR and open surgical repair. Methods an... Read More about The effect of aortic morphology on peri-operative mortality of ruptured abdominal aortic aneurysm.

Preoperative supervised exercise and outcomes following elective abdominal aortic aneurysm repair (2014)
Thesis
Barakat, H. M. (2014). Preoperative supervised exercise and outcomes following elective abdominal aortic aneurysm repair. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4216676

Objective
The aim of this research was to evaluate the role of preoperative supervised exercise training on perioperative outcomes and cardiopulmonary exercise testing (CPET) parameters in patients undergoing elective abdominal aortic aneurysm (AAA)... Read More about Preoperative supervised exercise and outcomes following elective abdominal aortic aneurysm repair.

The validity, reliability and responsiveness of procedure based assessment in simulated vascular procedures (2014)
Thesis
Green, L. A. (2014). The validity, reliability and responsiveness of procedure based assessment in simulated vascular procedures. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4216921

Introduction

Procedure based assessment (PBA) has been shown to be valid and reliable in the workplace however whether this translates to the simulation setting has not yet been demonstrated. Therefore the aim of this thesis is to demonstrate that... Read More about The validity, reliability and responsiveness of procedure based assessment in simulated vascular procedures.

Optimising outcomes in the treatment of superficial venous insufficiency (2014)
Thesis
Wallace, T. M. (2014). Optimising outcomes in the treatment of superficial venous insufficiency. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4216422

The traditional “gold-standard” treatment for symptomatic SVI affecting the GSV is conventional open surgery and stripping under general anaesthesia. Despite improved QoL and cost-effectiveness when compared to conservative management, conventional s... Read More about Optimising outcomes in the treatment of superficial venous insufficiency.

An RCT of clinical and cost effectiveness of endovenous laser therapy in the treatment of varicose veins secondary to isolated saphenopopliteal incompetence and small saphenous reflux (2014)
Thesis
Samuel, N. (2014). An RCT of clinical and cost effectiveness of endovenous laser therapy in the treatment of varicose veins secondary to isolated saphenopopliteal incompetence and small saphenous reflux. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4216284

BACKGROUND
Lower limb varicosities are common and cause significant impairment of quality of life to the sufferers. Patients with small saphenous incompetence form a small but significant part of this group who have traditionally been treated by sur... Read More about An RCT of clinical and cost effectiveness of endovenous laser therapy in the treatment of varicose veins secondary to isolated saphenopopliteal incompetence and small saphenous reflux.

Status update and interim results from the Asymptomatic Carotid Surgery Trial-2 (ACST-2) (2013)
Journal Article
ACST-2 Collaborative Group. (2013). Status update and interim results from the Asymptomatic Carotid Surgery Trial-2 (ACST-2). European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 46(5), 510-518. https://doi.org/10.1016/j.ejvs.2013.07.020

ObjectivesACST-2 is currently the largest trial ever conducted to compare carotid artery stenting (CAS) with carotid endarterectomy (CEA) in patients with severe asymptomatic carotid stenosis requiring revascularization.ResultsA total of 986 patients... Read More about Status update and interim results from the Asymptomatic Carotid Surgery Trial-2 (ACST-2).

Optimising outcomes in the treatment of lower limb varicose veins (2012)
Thesis
Mekako, A. (2012). Optimising outcomes in the treatment of lower limb varicose veins. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4214091

Varicose veins are dilated and tortuous subcutaneous veins, which affect a significant proportion of adults. They cause physical and emotional symptoms, and affect quality of life in sufferers. The management of varicose veins has evolved since the e... Read More about Optimising outcomes in the treatment of lower limb varicose veins.

Molecular imaging of gene transduction in cardiac transplantation (2012)
Thesis
Rao, V. P. (2012). Molecular imaging of gene transduction in cardiac transplantation. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4214665

This thesis is based on a series of experiments aimed at designing a model of gene transfer to the transplanted heart. The use of viral vector-based gene therapy to target pathological processes following cardiac transplantation faces many challenges... Read More about Molecular imaging of gene transduction in cardiac transplantation.

Abdominal aortic aneurysms : identification by self-examination and analysis of variation in matrix metalloproteinases with peak wall stress (2011)
Thesis
Heng, M. S. T. (2011). Abdominal aortic aneurysms : identification by self-examination and analysis of variation in matrix metalloproteinases with peak wall stress. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4213506

Abdominal aortic aneurysms (AAAs) cause 5,000 deaths a year in the UK. Self-examination for AAAs may provide an economic and practical solution. Matrix metalloproteinase (MMP) concentration is elevated and levels of their natural inhibitors - Tissue... Read More about Abdominal aortic aneurysms : identification by self-examination and analysis of variation in matrix metalloproteinases with peak wall stress.

Minimally invasive treatment of venous insufficiency using endovenous laser ablation (2011)
Thesis
Carradice, D. (2011). Minimally invasive treatment of venous insufficiency using endovenous laser ablation. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4211989

Background

Venous insufficiency is very common and causes significant quality of life (QoL) impairment. Conventional open surgery featuring junction ligation, stripping of the axial vein and phlebectomy is known to offer significant benefits over... Read More about Minimally invasive treatment of venous insufficiency using endovenous laser ablation.

Plasma tissue factor, tissue factor pathway inhibitor and restenosis following femoropopliteal percutaneous transluminal angioplasty in claudicants (2011)
Thesis
Ray, B. (2011). Plasma tissue factor, tissue factor pathway inhibitor and restenosis following femoropopliteal percutaneous transluminal angioplasty in claudicants. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4211926

Introduction: The primary goal in the management of intermittent claudication is to decrease cardiovascular morbidity and mortality by disease modifying therapy. However percutaneous transluminal angioplasty (PTA) is often performed to improve limb r... Read More about Plasma tissue factor, tissue factor pathway inhibitor and restenosis following femoropopliteal percutaneous transluminal angioplasty in claudicants.

Randomised controlled trials (RCTs) to evaluate complex healthcare interventions - A case study (2004)
Journal Article
Wong, I. C. K. (2004). Randomised controlled trials (RCTs) to evaluate complex healthcare interventions - A case study. Pharmacy world & science : PWS, 26(5), 247-252. https://doi.org/10.1023/B%3APHAR.0000042920.34663.04

In 2001 the UK National Health Service (NHS) issued its National Service Framework for the Elderly (NSF-E). This identified the elderly as a vulnerable group needing a high level of pharmaceutical intervention. As such, the NSF-E outlined plans to im... Read More about Randomised controlled trials (RCTs) to evaluate complex healthcare interventions - A case study.