All Outputs (12)

EGFR and related therapeutic targets in malignant pleural mesothelioma (2016)
Thesis
Oguh, L. I. (2016). EGFR and related therapeutic targets in malignant pleural mesothelioma. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4221787

Introduction
Malignant pleural mesothelioma (MPM) is a rare but aggressive disease and the current first line treatment is associated with a survival rate of 40%. There is currently no second line therapy. This study aimed to explore the expression... Read More about EGFR and related therapeutic targets in malignant pleural mesothelioma.

The role of the Kinin-Kallikrein System in chronic lymphocytic leukaemia (2014)
Thesis
Kashuba, E. (2014). The role of the Kinin-Kallikrein System in chronic lymphocytic leukaemia. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4216406

Background:
Chronic lymphocytic leukaemia (CLL) is an incurable heterogeneous disease. The identification of reliable and cost effective biomarkers is therefore imperative. A comparative proteomic approach was previously employed to study protein ex... Read More about The role of the Kinin-Kallikrein System in chronic lymphocytic leukaemia.

Identification of predictive biomarkers of resistance to radiotherapy in rectal cancer (2013)
Thesis
Mehmood, S. (2013). Identification of predictive biomarkers of resistance to radiotherapy in rectal cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4216079

Introduction and Aims:
Neoadjuvant radiotherapy (RT) provides local control of disease in rectal cancer, however, the ability to predict response to RT is limited. The aim of this study was to establish a novel radioresistant (RR) rectal cancer cell... Read More about Identification of predictive biomarkers of resistance to radiotherapy in rectal cancer.

Proteomic identification of putative biomarkers of radiotherapy resistance (2012)
Thesis
Scaife, L. (2012). Proteomic identification of putative biomarkers of radiotherapy resistance. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4214086

Background
Currently, tumour response to radiotherapy cannot be predicted meaning that those patients with tumours resistant to the therapy endure the harmful side effects associated with ionising radiation in the absence of therapeutic gain. The ai... Read More about Proteomic identification of putative biomarkers of radiotherapy resistance.

Proteomic identification and validation of biomarkers associated with resistance to radiotherapy in breast cancer (2012)
Thesis
ElFadl, D. (2012). Proteomic identification and validation of biomarkers associated with resistance to radiotherapy in breast cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4218629

Background:
Breast cancer is an important health issue. The majority of patients present with early stage cancer and are therefore candidates for breast conserving surgery and radiotherapy. A proportion will suffer from local recurrence, which may b... Read More about Proteomic identification and validation of biomarkers associated with resistance to radiotherapy in breast cancer.

The significance of the EGFR pathway in malignant pleural mesothelioma (2012)
Thesis
Agarwal, V. (. (2012). The significance of the EGFR pathway in malignant pleural mesothelioma. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4214047

Introduction
EGFR, MTOR and COX2 are up regulated in malignant pleural mesothelioma (MPM). In this study we aimed to determine the expression of Lipoxygenase enzymes (LOX), absence of PTEN protein expression and the cytotoxic effect of EGFR, MTOR an... Read More about The significance of the EGFR pathway in malignant pleural mesothelioma.

The identification of biomarkers of chemotherapy resistance in breast cancer using comparative proteomics (2011)
Thesis
Hodgkinson, V. C. (2011). The identification of biomarkers of chemotherapy resistance in breast cancer using comparative proteomics. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4211852

Background:Chemotherapy resistance is a major obstacle in effective neoadjuvant treatment for locally advanced breast cancer. The ability to predict tumour response would allow chemotherapy administration to be directed towards only those patients wh... Read More about The identification of biomarkers of chemotherapy resistance in breast cancer using comparative proteomics.

Novel anti-endothelial therapeutic strategies in malignant melanoma : the metronomic approach. (2011)
Thesis
Murray, A. M. (2011). Novel anti-endothelial therapeutic strategies in malignant melanoma : the metronomic approach. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4211876

Treatment strategies for advanced malignancy remain limited in their success, despite major advances in the understanding of cancer aetiology and molecular biology. The incidence of many cancers, including melanoma, continues to rise, with a huge dem... Read More about Novel anti-endothelial therapeutic strategies in malignant melanoma : the metronomic approach..

The proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia (2009)
Thesis
Eagle, G. L. (2009). The proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4209165

Chronic Lymphocytic Leukaemia (CLL) is the most common adult Leukaemia in the UK, Western Europe and America. It is a malignancy of naive B-cells. The clinical course of patients with CLL is heterogeneous; some patients survive for years without trea... Read More about The proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia.

Radioresistance in oral squamous cell carcinoma (2008)
Thesis
Murphy, J. T. (2008). Radioresistance in oral squamous cell carcinoma. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4208413

Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common cancer accounting for approximately 6% of all cancers worldwide. However the distribution across the globe varies considerably. The majority of small tumours of the oral cavity an... Read More about Radioresistance in oral squamous cell carcinoma.

The proteomic analysis of resistance to anticancer therapy in human breast cancer (2006)
Thesis
Smith, L. (2006). The proteomic analysis of resistance to anticancer therapy in human breast cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4212607

Resistance to anticancer therapy represents a major barrier in the successful management of human breast cancer. The identification of novel biomarkers that correlate with treatment response would increase our understanding of the resistance mechanis... Read More about The proteomic analysis of resistance to anticancer therapy in human breast cancer.

The role of chromosome 22 in the progression of head and neck squamous cell carninoma (2003)
Thesis
Condon, L. T. (2003). The role of chromosome 22 in the progression of head and neck squamous cell carninoma. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4223891

Head and neck squamous cell carcinoma (HNSCC) is one o f the ten most frequent cancers in the world. Despite advances in surgery, radiotherapy and chemotherapy over the last 30 years, there has been little improvement in the mortality rate from this... Read More about The role of chromosome 22 in the progression of head and neck squamous cell carninoma.