All Outputs (7)

Investigation into the role of the epigenetic target CBX2 in Glioblastoma (2024)
Thesis
Beattie, H. Investigation into the role of the epigenetic target CBX2 in Glioblastoma. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4866108

Glioblastoma (GBM) has been identified as an extremely difficult tumour to treat owing to issues of heterogeneity, as well as the aggressive nature of the tumours’ growth. Despite current treatments using a combination of methods, treatment resistanc... Read More about Investigation into the role of the epigenetic target CBX2 in Glioblastoma.

Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer (2022)
Thesis
Dobrowinski, W. Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4291232

Epigenetics is the study of the change in gene expression patterns that are not caused by direct alterations in the DNA nucleotide sequence but instead are as a result of the dynamic remodelling of the chromatin state. Regulation of the chromatin lan... Read More about Investigating the importance of CBX2’s structural motifs for its chromatin interactions and pro-oncogenic epigenetic regulatory function in triple negative breast cancer.

Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer (2022)
Thesis
Bilton, L. Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4240594

Breast cancer is the uncontrolled proliferation of breast cells and is one of the most common cancers in the UK. It is a complex disease that can be divided into different subtypes based upon the presence or lack of hormone receptors, namely the oest... Read More about Investigating the role Of CBX2 to promote cell growth in triple negative breast cancer.

Establishing a flow-based system for repressing target gene expression in a microfluidic device using a glioblastoma spheroid model (2022)
Thesis
Hosni Ep Ben Daoud, I. Establishing a flow-based system for repressing target gene expression in a microfluidic device using a glioblastoma spheroid model. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4224543

Glioblastoma (GBM) is a deadly disease with poor prognosis. The gold standard treatment is surgery followed by chemoradiotherapy almost always including Temozolomide. Despite extensive research for new therapeutic approaches relapse after treatment s... Read More about Establishing a flow-based system for repressing target gene expression in a microfluidic device using a glioblastoma spheroid model.

Investigation of the regulatory role of CBX2 in breast cancer via in silico transcriptomic analysis and in vitro cistromic analysis (2021)
Thesis
Kalsi, S. C. (2021). Investigation of the regulatory role of CBX2 in breast cancer via in silico transcriptomic analysis and in vitro cistromic analysis. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4224331

Chromobox 2 (CBX2) is a component of Polycomb repressive protein complex 1 (PRC1), which is an epigenetic regulatory complex that downregulates the expression of target genes. CBX2 has been linked to cancer progression and development in several canc... Read More about Investigation of the regulatory role of CBX2 in breast cancer via in silico transcriptomic analysis and in vitro cistromic analysis.

Investigating the role of CBX2 in ER- positive breast cancer (2019)
Thesis
Waters, E. J. (2019). Investigating the role of CBX2 in ER- positive breast cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222704

Breast cancer is the most common form of cancer in women, with oestrogen receptor (ER) positive breast cancers being the most common subtype. Although there are targeted endocrine therapies for this receptor, resistance mechanisms mean that they are... Read More about Investigating the role of CBX2 in ER- positive breast cancer.

Investigating the role of CBX2 in models of triple negative breast cancer (2019)
Thesis
Warren, C. (2019). Investigating the role of CBX2 in models of triple negative breast cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222872

Breast cancer accounts for around 11,500 deaths per year in the UK in women. There are several subtypes of breast cancer including triple negative breast cancer (TNBC) which is categorised by a lack of oestrogen, progesterone and human epidermal grow... Read More about Investigating the role of CBX2 in models of triple negative breast cancer.