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All Outputs (9)

Practice review: Pharmacological management of severe chronic breathlessness in adults with advanced life-limiting diseases (2024)
Journal Article
Simon, S. T., Higginson, I. J., Bausewein, C., Jolley, C. J., Bajwah, S., Maddocks, M., Wilharm, C., Oluyase, A. O., & Pralong, A. (online). Practice review: Pharmacological management of severe chronic breathlessness in adults with advanced life-limiting diseases. Palliative medicine, https://doi.org/10.1177/02692163241270945

Background: Severe and refractory chronic breathlessness is a common and burdensome symptom in patients with advanced life-limiting disease. Its clinical management is challenging because of the lack of effective interventions. Aim: To provide practi... Read More about Practice review: Pharmacological management of severe chronic breathlessness in adults with advanced life-limiting diseases.

Investigation of Aged Human Lung Endothelial Cells in Idiopathic Pulmonary Fibrosis (2024)
Thesis
Faulkner, E. C. Investigation of Aged Human Lung Endothelial Cells in Idiopathic Pulmonary Fibrosis. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4866422

Introduction
Older age is the main risk factor for idiopathic pulmonary fibrosis (IPF). Ageing-related changes in lung blood (pulmonary and bronchial) and lymphatic vessels are implicated in IPF pathophysiology, based on reports of their altered den... Read More about Investigation of Aged Human Lung Endothelial Cells in Idiopathic Pulmonary Fibrosis.

Identification of tumour anitgens that may facilitate effective cancer detection and treatment (2024)
Thesis
Mohamed, E. Identification of tumour anitgens that may facilitate effective cancer detection and treatment. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4866442

Tumour antigens (TAs) play a crucial role in terms of cancer diagnosis and targets for therapy. As TAs are normally expressed in restricted tissues such as testis, sensitivity and specificity may not be ideal, but they could still represent good biom... Read More about Identification of tumour anitgens that may facilitate effective cancer detection and treatment.

Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis (2022)
Journal Article
Allen, R. J., Stockwell, A., Oldham, J. M., Guillen-Guio, B., Schwartz, D. A., Maher, T. M., Flores, C., Noth, I., Yaspan, B. L., Jenkins, R. G., & Wain, L. V. (2022). Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis. Thorax, 77, 829-833. https://doi.org/10.1136/thoraxjnl-2021-218577

Idiopathic pulmonary fibrosis (IPF) is a chronic lung condition with poor survival times. We previously published a genome-wide meta-analysis of IPF risk across three studies with independent replication of associated variants in two additional studi... Read More about Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis.

Agreement between blood draw techniques for assessing platelet activation by flow cytometry (2018)
Journal Article
Welch, E. L., Crooks, M. G., & Hart, S. P. (2019). Agreement between blood draw techniques for assessing platelet activation by flow cytometry. Platelets, 30(4), 530-534. https://doi.org/10.1080/09537104.2018.1535705

It is widely believed that assays of platelet activation are susceptible to preanalytical variables related to blood draw technique. We assessed platelet activation by whole blood flow cytometry and investigated the effects of: (1) drawing blood into... Read More about Agreement between blood draw techniques for assessing platelet activation by flow cytometry.

Lung cancer (2018)
Book Chapter
Grundy, S., Barton, R., Campbell, A., Cowen, M., & Lind, M. (2018). Lung cancer. In S. Hart, & M. Greenstone (Eds.), Foundations of Respiratory Medicine (87-118). Springer. https://doi.org/10.1007/978-3-319-94127-1_6

The accurate diagnosis, staging and management of lung cancer occupies a large part of modern adult respiratory practice. Although smoking is less prevalent, the incidence and mortality of this condition remain high, and earlier detection through scr... Read More about Lung cancer.

Acute and chronic cough (2018)
Book Chapter
Morice, A. H., & Fowles, H. (2018). Acute and chronic cough. In S. Hart, & M. Greenstone (Eds.), Foundations of Respiratory Medicine (73-86). Springer. https://doi.org/10.1007/978-3-319-94127-1_5

Acute cough has a considerable economic impact within the UK because of lost work days. Chronic cough is one of the most common presentations to general respiratory clinics. Cough is often seen in tandem with a wide variety of respiratory conditions... Read More about Acute and chronic cough.

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study (2017)
Journal Article
Walsh, S. L., Maher, T. M., Kolb, M., Poletti, V., Nusser, R., Richeldi, L., …Wells, A. (2017). Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study. European respiratory journal, 50(2), Article 1700936. https://doi.org/10.1183/13993003.00936-2017

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts.

A total of 1141 respiratory physicians and 34 IPF experts p... Read More about Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study.