All Outputs (24)

Configurationally restricted bis-tetraazamacrocyclic complexes: chemokine receptor antagonists (2009)
Thesis
McRobbie, G. W. J. (2009). Configurationally restricted bis-tetraazamacrocyclic complexes: chemokine receptor antagonists. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4213191

The chemokine receptor CXCR4 is a trans-membrane protein which has been implicated in many physiological and pathological processes including cancer, rheumatoid arthritis and most significantly HIV replication. CXCR4 plays a vital role in embryonic d... Read More about Configurationally restricted bis-tetraazamacrocyclic complexes: chemokine receptor antagonists.

Synthesis of tetraazamacrocyclic complexes: Biomedical applications (2009)
Thesis
Mewis, R. E. (2009). Synthesis of tetraazamacrocyclic complexes: Biomedical applications. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4208988

Tetraazamacrocyclic frameworks of 1,4,7,10-tetraazacylcododecane (cyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam) with functional pendent arms and porphyrins with solubilising polyethylene glycol (PEG) chains have been synthesised. The pendent... Read More about Synthesis of tetraazamacrocyclic complexes: Biomedical applications.

Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer (2008)
Thesis
Welch, C. J. (2008). Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4208906

Porphyrin molecules are efficient generators of singlet oxygen and are used as photosensitisers in PDT. They are also known to accumulate in tumour tissue due to the hyperpermeability of tumour vasculature and poor lymphatic drainage, thus exhibiting... Read More about Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer.

The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents (2008)
Thesis
Sparke, A. E. (2008). The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4212783

Multimodality imaging agents have the potential to be detected in both MRI and optical imaging experiments allowing for visualisation of biological systems from the cellular level up to the whole body. Lanthanide complexes have shown great promise as... Read More about The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents.