Patterns and stages of α-synucleinopathy: Relevance in a population-based cohort

Zaccai, J.; Brayne, C.; McKeith, I.; Matthews, F.; Ince, P. G.

doi:10.1212/01.wnl.0000306697.48738.b6

Multi-state analysis of cognitive ability data: A piecewise-constant model and aWeibull model (2008)
Journal Article
van den Hout, A., & Matthews, F. E. (2008). Multi-state analysis of cognitive ability data: A piecewise-constant model and aWeibull model. Statistics in Medicine, 27(26), 5440-5455. https://doi.org/10.1002/sim.3360

Longitudinal data can be used to estimate transition intensities between healthy and unhealthy states prior to death. When health is defined with respect to cognitive ability during old age, the trajectory of performance is either static or downward.... Read More about Multi-state analysis of cognitive ability data: A piecewise-constant model and aWeibull model.

The Childhood Autism Spectrum Test (CAST): Sex differences (2008)
Journal Article
Williams, J. G., Allison, C., Scott, F. J., Bolton, P. F., Baron-Cohen, S., Matthews, F. E., & Brayne, C. (2008). The Childhood Autism Spectrum Test (CAST): Sex differences. Journal of Autism and Developmental Disorders, 38(9), 1731-1739. https://doi.org/10.1007/s10803-008-0558-6

The Childhood Autism Spectrum Test (CAST) (formally known as the Childhood Asperger Screening Test) identifies autism spectrum conditions by measuring social and communication skills. The present study explored the sex distribution of scores. The CAS... Read More about The Childhood Autism Spectrum Test (CAST): Sex differences.

Two-year progression from mild cognitive impairment to dementia: To what extent do different definitions agree? (2008)
Journal Article
Matthews, F. E., Stephan, B. C., McKeith, I. G., Bond, J., & Brayne, C. (2008). Two-year progression from mild cognitive impairment to dementia: To what extent do different definitions agree?. Journal of the American Geriatrics Society, 56(8), 1424-1433. https://doi.org/10.1111/j.1532-5415.2008.01820.x

OBJECTIVES: To determine the 2-year outcome from 16 different current classifications of mild cognitive impairment (MCI) in a population-based sample. DESIGN: Prospective cohort study: baseline and 2-year follow-up phases. SETTING: Large-scale multic... Read More about Two-year progression from mild cognitive impairment to dementia: To what extent do different definitions agree?.

Mild cognitive impairment in the older population: Who is missed and does it matter? (2008)
Journal Article
Stephan, B. C., Brayne, C., McKeith, I. G., Bond, J., & Matthews, F. E. (2008). Mild cognitive impairment in the older population: Who is missed and does it matter?. International journal of geriatric psychiatry, 23(8), 863-871. https://doi.org/10.1002/gps.2013

Objectives: Classifications of mild cognitive impairment (MCI) vary in the precision of the defining criteria. Their value in clinical settings is different from population settings. This difference depending on setting is to be expected, but must be... Read More about Mild cognitive impairment in the older population: Who is missed and does it matter?.

Thyroid function and cognitive decline in the MRC Cognitive Function and Ageing Study (2008)
Journal Article
Hogervorst, E., Huppert, F., Matthews, F. E., & Brayne, C. (2008). Thyroid function and cognitive decline in the MRC Cognitive Function and Ageing Study. Psychoneuroendocrinology, 33(7), 1013-1022. https://doi.org/10.1016/j.psyneuen.2008.05.008

Hypothyroidism and subclinical hyperthyroidism have both been associated with cognitive impairment and dementia. The association between thyroid stimulating hormone (TSH), free thyroid hormone or thyroxine (FT4) levels and cognition was investigated... Read More about Thyroid function and cognitive decline in the MRC Cognitive Function and Ageing Study.

The oldest old in England and Wales: A descriptive analysis based on the MRC cognitive function and ageing study (2008)
Journal Article
Xie, J., Matthews, F. E., Jagger, C., Bond, J., & Brayne, C. (2008). The oldest old in England and Wales: A descriptive analysis based on the MRC cognitive function and ageing study. Age and ageing, 37(4), 396-402. https://doi.org/10.1093/ageing/afn061

Objective: to describe the characteristics and survival of the oldest old in England and Wales. Design: retrospective analysis of the oldest old from a population-based cohort study. Setting: population-based study in England and Wales: two rural and... Read More about The oldest old in England and Wales: A descriptive analysis based on the MRC cognitive function and ageing study.

Impact of late-life self-reported emotional problems on Disability-Free Life Expectancy: Results from the MRC Cognitive Function and Ageing Study (2008)
Journal Article
Pérès, K., Jagger, C., & Matthews, F. E. (2008). Impact of late-life self-reported emotional problems on Disability-Free Life Expectancy: Results from the MRC Cognitive Function and Ageing Study. International journal of geriatric psychiatry, 23(6), 643-649. https://doi.org/10.1002/gps.1955

Objectives: Depression in old age is a major public health problem though its relationship to onset of disability and death is not well understood. We aim to quantify the impact of late-life self-reported depression and emotional problems on both the... Read More about Impact of late-life self-reported emotional problems on Disability-Free Life Expectancy: Results from the MRC Cognitive Function and Ageing Study.

A comparison of parametric models for the investigation of the shape of the cognitive change in the older population (2008)
Journal Article
Terrera, G. M., Matthews, F., & Brayne, C. (2008). A comparison of parametric models for the investigation of the shape of the cognitive change in the older population. BMC Neurology, 8, https://doi.org/10.1186/1471-2377-8-16

Background: Cognitive decline is a major threat to well being in later life. Change scores and regression based models have often been used for its investigation. Most methods used to describe cognitive decline assume individuals lose their cognitive... Read More about A comparison of parametric models for the investigation of the shape of the cognitive change in the older population.

An investigation of the population impact of variation in HbA <inf>1c</inf>levels in older people in England and Wales: From a population based multi-centre longitudinal study (2008)
Journal Article
Gao, L., Matthews, F. E., Sargeant, L. A., & Brayne, C. (2008). An investigation of the population impact of variation in HbA 1clevels in older people in England and Wales: From a population based multi-centre longitudinal study. BMC public health, 8, https://doi.org/10.1186/1471-2458-8-54

Background. Diabetes is common in the older population and is increasing. Glycated hemoglobin (HbA1c) is an indicator of average blood glucose concentration over the past three months. The HbA1ctest is currently one of clinical methods used to check... Read More about An investigation of the population impact of variation in HbA <inf>1c</inf>levels in older people in England and Wales: From a population based multi-centre longitudinal study.

Falls in advanced old age: Recalled falls and prospective follow-up of over-90-year-olds in the Cambridge City over-75s Cohort study (2008)
Journal Article
Fleming, J., Matthews, F. E., & Brayne, C. (2008). Falls in advanced old age: Recalled falls and prospective follow-up of over-90-year-olds in the Cambridge City over-75s Cohort study. BMC Geriatrics, 8, https://doi.org/10.1186/1471-2318-8-6

Background. The "oldest old" are now the fastest growing section of most western populations, yet there are scarcely any data concerning even the common problem of falls amongst the very old. Prospective data collection is encouraged as the most reli... Read More about Falls in advanced old age: Recalled falls and prospective follow-up of over-90-year-olds in the Cambridge City over-75s Cohort study.

Associations between active trachoma and community intervention with antibiotics, facial cleanliness, and environmental improvement (A,F,E) (2008)
Journal Article
Ngondi, J., Matthews, F., Reacher, M., Baba, S., Brayne, C., & Emerson, P. (2008). Associations between active trachoma and community intervention with antibiotics, facial cleanliness, and environmental improvement (A,F,E). PLoS Neglected Tropical Diseases, 2(4), https://doi.org/10.1371/journal.pntd.0000229

Background: Surgery, Antibiotics, Facial cleanliness and Environmental improvement (SAFE) are advocated by the World Health Organization (WHO) for trachoma control. However, few studies have evaluated the complete SAFE strategy, and of these, none ha... Read More about Associations between active trachoma and community intervention with antibiotics, facial cleanliness, and environmental improvement (A,F,E).

Co-occurrence of anxiety and depressive disorders in a community sample of older people: Results from the MRC CFAS (Medical Research Council Cognitive Function and Ageing Study) (2008)
Journal Article
Kvaal, K., McDougall, F. A., Brayne, C., Matthews, F. E., & Dewey, M. E. (2008). Co-occurrence of anxiety and depressive disorders in a community sample of older people: Results from the MRC CFAS (Medical Research Council Cognitive Function and Ageing Study). International journal of geriatric psychiatry, 23(3), 229-237. https://doi.org/10.1002/gps.1867

Background: Few population-based studies have examined the whole range of subthreshold syndromes and disorders of anxiety and depression in older people. Aims: To investigate the co-occurrence of anxiety and depressive syndromes in older people. Asso... Read More about Co-occurrence of anxiety and depressive disorders in a community sample of older people: Results from the MRC CFAS (Medical Research Council Cognitive Function and Ageing Study).

Survival times in people with dementia: Analysis from population based cohort study with 14 year follow-up (2008)
Journal Article
Xie, J., Brayne, C., & Matthews, F. E. (2008). Survival times in people with dementia: Analysis from population based cohort study with 14 year follow-up. BMJ, 336(7638), 258-262. https://doi.org/10.1136/bmj.39433.616678.25

Objectives: To provide estimates of survival after onset of dementia by age, sex, self reported health, disability, and severity of cognitive impairment. Design: Analysis of participants from prospective population based cohort study in 1991-2003, wi... Read More about Survival times in people with dementia: Analysis from population based cohort study with 14 year follow-up.

Community-level socio-economic status and cognitive and functional impairment in the older population (2008)
Journal Article
Basta, N. E., Matthews, F. E., Chatfield, M. D., & Brayne, C. (2008). Community-level socio-economic status and cognitive and functional impairment in the older population. European Journal of Public Health, 18(1), 48-54. https://doi.org/10.1093/eurpub/ckm076

Background: This study aimed to determine if people living in communities with higher socio-economic deprivation are at an increased risk of cognitive and functional impairment even after controlling for the effects of individual socio-economic statu... Read More about Community-level socio-economic status and cognitive and functional impairment in the older population.

Dementia and survival in parkinson disease: A 12-year population study (2008)
Journal Article
Buter, T. C., van den Hout, A., Matthews, F. E., Larsen, J. P., Brayne, C., & Aarsland, D. (2008). Dementia and survival in parkinson disease: A 12-year population study. Neurology, 70(13), 1017-1022. https://doi.org/10.1212/01.wnl.0000306632.43729.24

The risk for dementia in Parkinson disease (PD) is high, with important clinical consequences for patients with PD. However, the absolute risk of dementia and how it affects survival in PD are not known. Such questions are important for patients, the... Read More about Dementia and survival in parkinson disease: A 12-year population study.

Patterns and stages of α-synucleinopathy: Relevance in a population-based cohort (2008)
Journal Article
Zaccai, J., Brayne, C., McKeith, I., Matthews, F., & Ince, P. G. (2008). Patterns and stages of α-synucleinopathy: Relevance in a population-based cohort. Neurology, 70(13), 1042-1048. https://doi.org/10.1212/01.wnl.0000306697.48738.b6

It is proposed that α-synucleinopathy (AS) initially affects the medulla oblongata and progresses to more rostral brain areas in a hierarchical sequence (“Braak hypothesis”). Predominant involvement of the amygdala is also described. This study exami... Read More about Patterns and stages of α-synucleinopathy: Relevance in a population-based cohort.

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