All Outputs (23)

Evaluation of iron supplementation and its effect on postoperative outcomes in non-anaemic iron deficient patients undergoing surgery, with a focus on lower limb arthroplasty (2024)
Thesis
Randall, J. (2024). Evaluation of iron supplementation and its effect on postoperative outcomes in non-anaemic iron deficient patients undergoing surgery, with a focus on lower limb arthroplasty. (Thesis). University of Hull and University of York. Retrieved from https://hull-repository.worktribe.com/output/4659916

Aim Non-anaemic iron deficiency although identified as a potential area for improving patient outcome in the literature, its effect on patient outcomes post-surgery is an under researched topic, with numerous gaps in the published literature. The ai... Read More about Evaluation of iron supplementation and its effect on postoperative outcomes in non-anaemic iron deficient patients undergoing surgery, with a focus on lower limb arthroplasty.

The differential effect of intravenous iron in patients with non-dialysis chronic kidney disease in terms of fibroblast growth factor 23, phosphate, bone metabolism, functional status and quality of life and cardiovascular variables (2024)
Thesis
Kassianides, X. (2024). The differential effect of intravenous iron in patients with non-dialysis chronic kidney disease in terms of fibroblast growth factor 23, phosphate, bone metabolism, functional status and quality of life and cardiovascular variables. (Thesis). University of Hull and University of York. Retrieved from https://hull-repository.worktribe.com/output/4659777

Background: Modern intravenous iron preparations (e.g. ferric derisomaltose (FDI), ferric carboxymaltose (FCM)) are commonly used in non-dialysis-dependent chronic kidney disease (CKD) patients. Despite similar efficacy and safety in terms of previou... Read More about The differential effect of intravenous iron in patients with non-dialysis chronic kidney disease in terms of fibroblast growth factor 23, phosphate, bone metabolism, functional status and quality of life and cardiovascular variables.

The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation (2024)
Thesis
Greaves, J. (2024). The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4609527

The proper activation and subsequent differentiation of naive CD4+ T cells into effector T helper and regulatory T cells is vital for directing an appropriate adaptive immune response to specific infections. Recent evidence has identified long non-co... Read More about The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation.

Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis (2024)
Thesis
Muscutt, E. W. (2024). Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis. (Thesis). University of Hull and University of York. Retrieved from https://hull-repository.worktribe.com/output/4557553

Visceral leishmaniasis (VL) causes immune and haematological dysfunction and is fatal in >95% of cases if left untreated. While macrophages are vital for efficient Leishmania parasite clearance, parasite-macrophage interactions are critical for VL pr... Read More about Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis.

The role of cardiopulmonary exercise testing for identifying possible silent myocardial ischaemia in people with coronary heart disease (2024)
Thesis
Nickolay, T. (2024). The role of cardiopulmonary exercise testing for identifying possible silent myocardial ischaemia in people with coronary heart disease. (Thesis). University of Hull and University of York. Retrieved from https://hull-repository.worktribe.com/output/4659878

This thesis investigates the utility of cardiopulmonary exercise testing (CPET) in assessing and managing patients with coronary artery disease (CAD), particularly focusing on the significance of oxygen pulse (O2Pulse) inflections as a marker for myo... Read More about The role of cardiopulmonary exercise testing for identifying possible silent myocardial ischaemia in people with coronary heart disease.

Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery (2023)
Thesis
Meddick-Dyson, S. (2023). Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4587991

Background Palliative and end-of-life care have important roles in intensive care units (ICUs) given symptom burden and rate of mortality in ICUs. However, we do not know how ICU-based palliative care interventions should be implemented. This system... Read More about Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery.

Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I (2023)
Thesis
Bolanle, O. I. (2023). Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4420724

Despite the plethora of drugs currently available for managing coronary artery disease (CAD) patients with or without type 2 diabetes mellitus (T2DM), yet CAD frequently progresses, necessitating a coronary artery bypass graft (CABG) procedure using... Read More about Identification of Novel Glucose-Dependent Alterations Responsible for Vascular Dysfunction in Type 2 Diabetes Mellitus (T2DM) I.

Low-dose methotrexate: not the hepatotoxic medication we once thought (2023)
Thesis
Turner, L. V. B. (2023). Low-dose methotrexate: not the hepatotoxic medication we once thought. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4443697

Methotrexate is a highly efficacious and frequently utilised disease-modifying medication. Concern regarding methotrexate-related hepatotoxicity has impeded the widespread application of the drug, despite a lack of high-quality evidence demonstrating... Read More about Low-dose methotrexate: not the hepatotoxic medication we once thought.

Predicting and preventing relapse of depression in primary care: a mixed methods study (2023)
Thesis
Moriarty, A. S. (2023). Predicting and preventing relapse of depression in primary care: a mixed methods study. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4483741

Background Most people with depression are managed in primary care. Relapse (reemergence of depression symptoms after improvement) is common and contributes to the burden and morbidity associated with depression. There is a lack of evidence-based ap... Read More about Predicting and preventing relapse of depression in primary care: a mixed methods study.

The Host-Microbiota Axis in Chronic Wound Healing (2023)
Thesis
Stafford, A. R. (2023). The Host-Microbiota Axis in Chronic Wound Healing. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4424929

Chronic, non-healing skin wounds represent a substantial area of unmet clinical need, leading to debilitating morbidity and mortality in affected individuals. Due to their high prevalence and recurrence, chronic wounds pose a significant economic bur... Read More about The Host-Microbiota Axis in Chronic Wound Healing.

Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells (2023)
Thesis
Haque, F. (2023). Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4371279

The premalignant pancreatic cellular genotype can remain stable for years before rapid malignant transformation, often associated with inflammation. Tissue factor (TF) is an inflammatory modulator regulated by factor VIIa (fVIIa) for its levels and a... Read More about Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells.

Exploring the experiences of support with parentally bereaved children and their surviving parents using constructivist grounded theory (2023)
Thesis
Wray, A. (2023). Exploring the experiences of support with parentally bereaved children and their surviving parents using constructivist grounded theory. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4609487

Background: In the UK, 46,300 children are bereaved of a parent each year. We understand bereaved people need a supportive response from those around them. However, there is limited evidence to inform our understanding of this. Aim: To explore how c... Read More about Exploring the experiences of support with parentally bereaved children and their surviving parents using constructivist grounded theory.

Addressing delays to treatment in patients with chronic limb-threatening ischaemia (2023)
Thesis
Birmpili, P. (2023). Addressing delays to treatment in patients with chronic limb-threatening ischaemia. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4371299

Patients with CLTI often face long delays from referral to the vascular surgery service and hospital admission to revascularisation, and there is limited evidence on the effect of these delays on patient outcomes. This thesis aims to identify factors... Read More about Addressing delays to treatment in patients with chronic limb-threatening ischaemia.

Authentic alignment : toward an Interpretative Phenomenological Analysis (IPA) informed model of the learning environment in health professions education (2023)
Thesis
Kirkness, K. (2023). Authentic alignment : toward an Interpretative Phenomenological Analysis (IPA) informed model of the learning environment in health professions education. (Thesis). University of Hull and University of York. Retrieved from https://hull-repository.worktribe.com/output/4407885

It is well established that the goals of education can only be achieved through the constructive alignment of instruction, learning and assessment. There is a gap in research interpreting the lived experiences of stakeholders within the UK learning e... Read More about Authentic alignment : toward an Interpretative Phenomenological Analysis (IPA) informed model of the learning environment in health professions education.

The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos (2023)
Thesis
Martin, F. (2023). The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4430667

Background: Blood-derived products are a growing area of therapeutic treatments for a diverse range of conditions, including hair loss, scarring, muscle injury, wounds, arthritis, and symptoms related to the menopause. Platelet-rich plasma (PRP) is o... Read More about The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos.

Clinical and confidence outcomes following through-knee versus above-knee amputation : a quantitative study (2023)
Thesis
Boam, G. L. (2023). Clinical and confidence outcomes following through-knee versus above-knee amputation : a quantitative study. (Thesis). University of Hull and University of York. Retrieved from https://hull-repository.worktribe.com/output/4567461

Following surgery, patients with a major lower limb amputation face physical and mental health challenges. For clinicians and physiotherapists to reach a consensus and provide a suitable level of amputation for each patient, the understanding of post... Read More about Clinical and confidence outcomes following through-knee versus above-knee amputation : a quantitative study.

Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation (2022)
Thesis
Isaac, E. S. (2022). Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4508137

Atrial Fibrillation (AF) is the most common cardiac arrhythmia worldwide with sufferers of the condition facing significant morbidity and mortality. Ageing alone is identified as the most significant risk factor for developing the arrhythmia. As such... Read More about Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation.

A mixed methods study of outcomes, experiences, and perceptions of through-knee and above-knee amputation (2022)
Thesis
Crane, H. (2022). A mixed methods study of outcomes, experiences, and perceptions of through-knee and above-knee amputation. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4312145

Through-knee amputation (TKA) has several theoretical physical advantages over above-knee amputation (AKA), yet AKA remains the preferred level of amputation by UK vascular surgeons when below-knee amputation (BKA) is not feasible. How clinician’s pe... Read More about A mixed methods study of outcomes, experiences, and perceptions of through-knee and above-knee amputation.

Determination of epithelial growth factor receptor mutations in circulatory tumour cells from non-small cell lung cancer patients isolated using a novel microfluidic device (2022)
Thesis
Ogidi, N. O. (2022). Determination of epithelial growth factor receptor mutations in circulatory tumour cells from non-small cell lung cancer patients isolated using a novel microfluidic device. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4270004

Patients with epidermal growth factor receptor (EGFR) sensitizing mutations in non small cell lung cancer (NSCLC) receive benefit from Tyrosine Kinase inhibitors. Accurate selection of patients before treatment is highly dependent on precise molecula... Read More about Determination of epithelial growth factor receptor mutations in circulatory tumour cells from non-small cell lung cancer patients isolated using a novel microfluidic device.

The detection and assessment of malnutrition, sarcopenia and cachexia, in older adults with cancer (2022)
Thesis
Bullock, A. F. (2022). The detection and assessment of malnutrition, sarcopenia and cachexia, in older adults with cancer. (Thesis). Hull York Medical School. Retrieved from https://hull-repository.worktribe.com/output/4484119

Background: Older adults with cancer are a complex and growing population requiring tailored care to achieve optimum treatment outcomes. However, their care is complicated by underrecognised and under-treated nutrition-related wasting disorders: mal... Read More about The detection and assessment of malnutrition, sarcopenia and cachexia, in older adults with cancer.