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All Outputs (8)

Depression in the elderly: Pathological study of raphe and locus ceruleus (2005)
Journal Article
Syed, A., Chatfield, M., Matthews, F., Harrison, P., Brayne, C., & Esiri, M. M. (2005). Depression in the elderly: Pathological study of raphe and locus ceruleus. Neuropathology and Applied Neurobiology, 31(4), 405-413. https://doi.org/10.1111/j.1365-2990.2005.00662.x

Depressive symptoms in the elderly are common and disabling and constitute a risk factor for the development of Alzheimer's disease (AD). One hypothesis worth exploring is that depression in the elderly is related to development of AD pathology at su... Read More about Depression in the elderly: Pathological study of raphe and locus ceruleus.

Brief cognitive assessment in a UK population sample - Distributional properties and the relationship between the MMSE and an extended mental state examination (2005)
Journal Article
Huppert, F. A., Cabelli, S. T., & Matthews, F. E. (2005). Brief cognitive assessment in a UK population sample - Distributional properties and the relationship between the MMSE and an extended mental state examination. BMC Geriatrics, 5, https://doi.org/10.1186/1471-2318-5-7

Background: Despite the MMSE's known flaws, it is still used extensively as both a screening instrument for dementia and a population measure of cognitive ability. The aim of this paper is to provide data on the distribution of MMSE scores in a repre... Read More about Brief cognitive assessment in a UK population sample - Distributional properties and the relationship between the MMSE and an extended mental state examination.

Brain donation for research: consent and re-consent post Alder Hey. (2005)
Journal Article
Barnes, L., Matthews, F. E., Barber, B., Davies, L., Lloyd, D., Brayne, C., & Parry, B. (2005). Brain donation for research: consent and re-consent post Alder Hey

Background: Recent scandals relating to the unconsented retention and use of human organs in the UK have led to widespread changes to governance and ethical frameworks for research throughout England and Wales. Ethics committees now ask for proof of... Read More about Brain donation for research: consent and re-consent post Alder Hey..

The incidence of dementia in England and Wales: Findings from the five identical sites of the MRC CFA study (2005)
Journal Article
Matthews, F., Brayne, C., Arie, T., Bond, J., Copeland, J., Day, N., …Parker, C. (2005). The incidence of dementia in England and Wales: Findings from the five identical sites of the MRC CFA study. PLoS Medicine, 2(8), 0753-0763. https://doi.org/10.1371/journal.pmed.0020193

Background: Although incidence of dementia is known to vary between nations, variation within country has not been explored because most incidence studies are single site or have insufficient numbers to compare sites. Few countries have conducted mul... Read More about The incidence of dementia in England and Wales: Findings from the five identical sites of the MRC CFA study.

Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression (2005)
Journal Article
Brayne, C., Gao, L., & Matthews, F. (2005). Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression. Neurobiology of Aging, 26(SUPPL.), 6-10. https://doi.org/10.1016/j.neurobiolaging.2005.09.030

There are many challenges facing epidemiologists wishing to investigate relationships between physical activity, obesity, diabetes, dementia and depression, all of which are complex fields in their own right. There is a large literature investigating... Read More about Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression.

Diseases and impairments as risk factors for onset of disability in the older population in England and Wales: Findings from the medical research council cognitive function and ageing study (2005)
Journal Article
Spiers, N. A., Matthews, R. J., Jagger, C., Matthews, F. E., Boult, C., Robinson, T. G., & Brayne, C. (2005). Diseases and impairments as risk factors for onset of disability in the older population in England and Wales: Findings from the medical research council cognitive function and ageing study. The journals of gerontology. Series A, Biological sciences and medical sciences, 60(2), 248-254. https://doi.org/10.1093/gerona/60.2.248

Background. This paper reports the association between self-reported diseases and impairments and 2-year onset of disability in a prospective study of people aged 65 years or older in five urban and rural centers in England and Wales (Medical Researc... Read More about Diseases and impairments as risk factors for onset of disability in the older population in England and Wales: Findings from the medical research council cognitive function and ageing study.

A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies (2005)
Journal Article
Chatfield, M. D., Brayne, C. E., & Matthews, F. E. (2005). A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies. Journal of clinical epidemiology, 58(1), 13-19. https://doi.org/10.1016/j.jclinepi.2004.05.006

Longitudinal studies of the elderly are complicated by the loss of individuals between waves due to death or other dropout mechanisms. Factors that affect dropout may well be similar from one study to another. This article systematically reviews all... Read More about A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies.