Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain

Simpson, J. E.; Ince, P. G.; Haynes, L. J.; Theaker, R.; Gelsthorpe, C.; Baxter, L.; Forster, G.; Lace, G. L.; Shaw, P. J.; Matthews, F. E.; Savva, G. M.; Brayne, C.; Wharton, S. B.

doi:10.1111/j.1365-2990.2009.01030.x

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Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain (2010)
Journal Article
Simpson, J. E., Ince, P. G., Haynes, L. J., Theaker, R., Gelsthorpe, C., Baxter, L., …Wharton, S. B. (2010). Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathology and Applied Neurobiology, 36(1), 25-40. https://doi.org/10.1111/j.1365-2990.2009.01030.x

Aims: Increasing evidence suggests a role for oxidative damage to DNA in brain ageing and in neurodegenerative disorders, including Alzheimer's disease. Most studies have focussed on the reduced capacity for DNA repair by neurones, and have not taken... Read More about Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.