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DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: A population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort (2014)
Journal Article
Garwood, C. J., Simpson, J. E., Al Mashhadi, S., Axe, C., Wilson, S., Heath, P. R., …Wharton, S. B. (2014). DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: A population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort. Neuropathology and Applied Neurobiology, 40(7), 802-814. https://doi.org/10.1111/nan.12156

Aims: Abnormalities of the brain microvasculature in Alzheimer's disease have led to the vascular hypothesis of the disease, which predicts that vascular changes precede neuronal dysfunction and degeneration. To determine the spectrum of endothelial... Read More about DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: A population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort.

Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: A meta-analysis (2014)
Journal Article
Wu, Y. T., Lee, H. Y., Norton, S., Prina, A. M., Fleming, J., Matthews, F. E., & Brayne, C. (2014). Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: A meta-analysis. International journal of geriatric psychiatry, 29(12), 1212-1220. https://doi.org/10.1002/gps.4148

Objective: There have been dramatic societal changes in East Asia over the last hundred years. Several of the established risk factors could have important period and cohort effects. This study explores temporal variation of dementia prevalence in ma... Read More about Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: A meta-analysis.

The descriptive epidemiology of delirium symptoms in a large population-based cohort study: Results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2014)
Journal Article
Davis, D. H., Barnes, L. E., Stephan, B. C., Maclullich, A. M., Meagher, D., Copeland, J., …Brayne, C. (2014). The descriptive epidemiology of delirium symptoms in a large population-based cohort study: Results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). BMC Geriatrics, 14(1), https://doi.org/10.1186/1471-2318-14-87

Background: In the general population, the epidemiological relationships between delirium and adverse outcomes are not well defined. The aims of this study were to: (1) construct an algorithm for the diagnosis of delirium using the Geriatric Mental S... Read More about The descriptive epidemiology of delirium symptoms in a large population-based cohort study: Results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

C-reactive protein, APOE genotype and longitudinal cognitive change in an older population (2014)
Journal Article
Lima, T. A., Adler, A. L., Minett, T., Matthews, F. E., Brayne, C., & Marioni, R. E. (2014). C-reactive protein, APOE genotype and longitudinal cognitive change in an older population. Age and ageing, 43(2), 289-292. https://doi.org/10.1093/ageing/aft193

Background: circulating measures of inflammatory markers, such as C-reactive protein (CRP) have been associated with an increased risk of future cognitive decline. However, the nature of the relationship among the very old (>75 years) is unclear. Cro... Read More about C-reactive protein, APOE genotype and longitudinal cognitive change in an older population.

Education associated with a delayed onset of terminal decline (2014)
Journal Article
Terrera, G. M., Minett, T., Brayne, C., & Matthews, F. E. (2014). Education associated with a delayed onset of terminal decline. Age and ageing, 43(1), 26-31. https://doi.org/10.1093/ageing/aft150

Background: the terminal decline hypothesis suggests an acceleration in the rate of loss of cognitive function before death. Evidence about the association of educational attainment and the onset of terminal decline is scarce. Objective: to investiga... Read More about Education associated with a delayed onset of terminal decline.

Brain haemosiderin in older people: Pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds (2014)
Journal Article
Janaway, B. M., Simpson, J. E., Hoggard, N., Highley, J. R., Forster, G., Drew, D., …Ince, P. G. (2014). Brain haemosiderin in older people: Pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds. Neuropathology and Applied Neurobiology, 40(3), 258-269. https://doi.org/10.1111/nan.12062

Introduction: Magnetic resonance imaging (MRI) cerebral microbleeds (CMB) arise from ferromagnetic haemosiderin iron assumed to derive from extravasation of erythrocytes. Light microscopy of ageing brain frequently reveals foci of haemosiderin from s... Read More about Brain haemosiderin in older people: Pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds.

Comparison between a Mandarin Chinese version of the Childhood Autism Spectrum Test and the Clancy Autism Behaviour Scale in mainland China (2014)
Journal Article
Sun, X., Allison, C., Auyeung, B., Matthews, F. E., Zhang, Z., Baron-Cohen, S., & Brayne, C. (2014). Comparison between a Mandarin Chinese version of the Childhood Autism Spectrum Test and the Clancy Autism Behaviour Scale in mainland China. Research in Developmental Disabilities, 35(7), 1599-1608. https://doi.org/10.1016/j.ridd.2014.02.005

A Mandarin Chinese version of the Childhood Autism Spectrum Test (CAST) and Clancy Autism Behaviour Scale (CABS) were applied to 150 children aged 4-11 years old from clinical settings and mainstream schools in Beijing. All the children were further... Read More about Comparison between a Mandarin Chinese version of the Childhood Autism Spectrum Test and the Clancy Autism Behaviour Scale in mainland China.

Grouping of behavioural and psychological symptoms of dementia (2014)
Journal Article
Van Der Linde, R. M., Dening, T., Matthews, F. E., & Brayne, C. (2014). Grouping of behavioural and psychological symptoms of dementia. International journal of geriatric psychiatry, 29(6), 562-568. https://doi.org/10.1002/gps.4037

Objective A wide range of behavioural and psychological symptoms (BPSD) are common in dementia, and it has been suggested that groups of correlated symptoms should be studied together. Here, we describe the groups of BPSD that have been identified in... Read More about Grouping of behavioural and psychological symptoms of dementia.

Cognitive lifestyle jointly predicts longitudinal cognitive decline and mortality risk (2014)
Journal Article
Marioni, R. E., Proust-Lima, C., Amieva, H., Brayne, C., Matthews, F. E., Dartigues, J. F., & Jacqmin-Gadda, H. (2014). Cognitive lifestyle jointly predicts longitudinal cognitive decline and mortality risk. European Journal of Epidemiology, 29(3), 211-219. https://doi.org/10.1007/s10654-014-9881-8

Cognitive lifestyle measures such as education, occupation, and social engagement are commonly associated with late-life cognitive ability although their associations with cognitive decline tend to be mixed. However, longitudinal analyses of cognitio... Read More about Cognitive lifestyle jointly predicts longitudinal cognitive decline and mortality risk.

Investigating healthy life expectancy using a multi-state model in the presence of missing data and misclassification (2014)
Journal Article
van den Hout, A., Ogurtsova, E., Gampe, J., & Matthews, F. E. (2014). Investigating healthy life expectancy using a multi-state model in the presence of missing data and misclassification. https://doi.org/10.4054/DemRes.2014.30.42

Background: A continuous-time three-state model can be used to describe change in cognitive function in the older population. State 1 corresponds to normal cognitive function, state 2 to cognitive impairment, and state 3 to dead. For statistical infe... Read More about Investigating healthy life expectancy using a multi-state model in the presence of missing data and misclassification.

Psychometric properties of the Mandarin version of the Childhood Autism Spectrum Test (CAST): An exploratory study (2014)
Journal Article
Sun, X., Allison, C., Auyeung, B., Matthews, F. E., Norton, S., Baron-Cohen, S., & Brayne, C. (2014). Psychometric properties of the Mandarin version of the Childhood Autism Spectrum Test (CAST): An exploratory study. Journal of Autism and Developmental Disorders, 44(7), 1565-1576. https://doi.org/10.1007/s10803-013-2024-3

Limited studies have investigated the latent autistic traits in the mainland Chinese population for autism spectrum conditions (ASC). This study explored the psychometric properties of a Mandarin Chinese version of the CAST in a sample consisting of... Read More about Psychometric properties of the Mandarin version of the Childhood Autism Spectrum Test (CAST): An exploratory study.

Potential for primary prevention of Alzheimer's disease: An analysis of population-based data (2014)
Journal Article
Norton, S., Matthews, F. E., Barnes, D. E., Yaffe, K., & Brayne, C. (2014). Potential for primary prevention of Alzheimer's disease: An analysis of population-based data. Lancet Neurology, 13(8), 788-794. https://doi.org/10.1016/S1474-4422%2814%2970136-X

Background: Recent estimates suggesting that over half of Alzheimer's disease burden worldwide might be attributed to potentially modifiable risk factors do not take into account risk-factor non-independence. We aimed to provide specific estimates of... Read More about Potential for primary prevention of Alzheimer's disease: An analysis of population-based data.

Drivers of inequality in disability-free expectancy at birth and age 85 across space and time in Great Britain (2014)
Journal Article
Wohland, P., Rees, P., Gillies, C., Alvanides, S., Matthews, F. E., O'Neill, V., & Jagger, C. (2014). Drivers of inequality in disability-free expectancy at birth and age 85 across space and time in Great Britain. Journal of Epidemiology and Community Health, 68(9), 826-833. https://doi.org/10.1136/jech-2014-204083

Background: Although mortality and health inequalities at birth have increased both geographically and in socioeconomic terms, little is known about inequalities at age 85, the fastest growing sector of the population in Great Britain (GB). Aim To de... Read More about Drivers of inequality in disability-free expectancy at birth and age 85 across space and time in Great Britain.

The Mandarin Childhood Autism Spectrum Test (CAST): Sex differences (2014)
Journal Article
Sun, X., Allison, C., Auyeung, B., Matthews, F. E., Sharp, S. J., Baron-Cohen, S., & Brayne, C. (2014). The Mandarin Childhood Autism Spectrum Test (CAST): Sex differences. Journal of Autism and Developmental Disorders, 44(9), 2137-2146. https://doi.org/10.1007/s10803-014-2088-8

Sex differences in social and communication behaviours related to autism spectrum conditions (ASC) have been investigated mainly in Western populations. Little research has been done in Chinese populations. This study explored sex differences related... Read More about The Mandarin Childhood Autism Spectrum Test (CAST): Sex differences.

TDP-43 pathology in the population: Prevalence and associations with dementia and age (2014)
Journal Article
Keage, H. A., Hunter, S., Matthews, F. E., Ince, P. G., Hodges, J., Hokkanen, S. R., …Brayne, C. (2014). TDP-43 pathology in the population: Prevalence and associations with dementia and age. Journal of Alzheimer's Disease, 42(2), 641-650. https://doi.org/10.3233/JAD-132351

Objective: We aimed to determine the prevalence of transactive response DNA-binding protein of 43 kDA (TDP-43) neuronal inclusions in a population-based sample, and associations with age group at death (≤90 and >90 years) and clinical dementia status... Read More about TDP-43 pathology in the population: Prevalence and associations with dementia and age.

Dementia: Time trends and policy responses (2014)
Journal Article
Wu, Y. T., Matthews, F. E., & Brayne, C. (2014). Dementia: Time trends and policy responses. Maturitas, 79(2), 191-195. https://doi.org/10.1016/j.maturitas.2014.06.020

In recent years, dementia has been considered a public health priority and become a topic of major political interest. Recent reviews and studies have reported with varying degrees of alarm an impending and existing "dementia epidemic" with increasin... Read More about Dementia: Time trends and policy responses.

Assessing environmental features related to mental health: A reliability study of visual streetscape images (2014)
Journal Article
Wu, Y. T., Nash, P., Barnes, L. E., Minett, T., Matthews, F. E., Jones, A., & Brayne, C. (2014). Assessing environmental features related to mental health: A reliability study of visual streetscape images. BMC public health, 14(1), https://doi.org/10.1186/1471-2458-14-1094

Background: An association between depressive symptoms and features of built environment has been reported in the literature. A remaining research challenge is the development of methods to efficiently capture pertinent environmental features in rele... Read More about Assessing environmental features related to mental health: A reliability study of visual streetscape images.

Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue (2014)
Journal Article
Love, S., Chalmers, K., Ince, P., Esiri, M., Attems, J., Jellinger, K., …Kehoe, P. G. (2014). Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue. American Journal of Neurodegenerative Disease, 3(1), 19-32

In a collaboration involving 11 groups with research interests in cerebral amyloid angiopathy (CAA), we used a two-stage process to develop and in turn validate a new consensus protocol and scoring scheme for the assessment of CAA and associated vasc... Read More about Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue.

The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study protocol: A cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing (2014)
Journal Article
Shafto, M. A., Tyler, L. K., Dixon, M., Taylor, J. R., Rowe, J. B., Cusack, R., …Matthews, F. E. (2014). The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study protocol: A cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing. BMC Neurology, 14(1), https://doi.org/10.1186/s12883-014-0204-1

Background: As greater numbers of us are living longer, it is increasingly important to understand how we can age healthily. Although old age is often stereotyped as a time of declining mental abilities and inflexibility, cognitive neuroscience revea... Read More about The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study protocol: A cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing.