Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain

Bury, Joanna J.; Chambers, Annabelle; Heath, Paul R.; Ince, Paul G.; Shaw, Pamela J.; Matthews, Fiona E.; Brayne, Carol; Simpson, Julie E.; Wharton, Stephen B.

doi:10.1186/s40478-020-01109-y

Static Socio-Ecological COVID-19 Vulnerability Index and Vaccine Hesitancy Index for England (2021)
Journal Article
Welsh, C. E., Sinclair, D. R., & Matthews, F. E. (2022). Static Socio-Ecological COVID-19 Vulnerability Index and Vaccine Hesitancy Index for England. The Lancet Regional Health Europe, 14, Article 100296. https://doi.org/10.1016/j.lanepe.2021.100296

Background: Population characteristics can be used to infer vulnerability of communities to COVID-19, or to the likelihood of high levels of vaccine hesitancy. Communities harder hit by the virus, or at risk of being so, stand to benefit from greater... Read More about Static Socio-Ecological COVID-19 Vulnerability Index and Vaccine Hesitancy Index for England.

Frailty among Older Adults and Its Distribution in England (2021)
Journal Article
Sinclair, D. R., Maharani, A., Chandola, T., Bower, P., Hanratty, B., Nazroo, J., …Pendleton, N. (2022). Frailty among Older Adults and Its Distribution in England. The Journal of frailty & aging, 11(2), 163-168. https://doi.org/10.14283/jfa.2021.55

Background: Information on the spatial distribution of the frail population is crucial to inform service planning in health and social care. Objectives: To estimate small-area frailty prevalence among older adults using survey data. To assess whether... Read More about Frailty among Older Adults and Its Distribution in England.

Psychological Processes in Adapting to Dementia: Illness Representations Among the IDEAL Cohort (2021)
Journal Article
Clare, L., Gamble, L. D., Martyr, A., Quinn, C., Litherland, R., Morris, R. G., …Matthews, F. E. (2022). Psychological Processes in Adapting to Dementia: Illness Representations Among the IDEAL Cohort. Psychology and Aging, 37(4), 524-541. https://doi.org/10.1037/pag0000650

How people understand and adapt to living with dementia may influence well-being. Leventhal’s Common Sense Model (CSM) of Self-Regulation provides a theoretical basis for exploring this process. We used crosssectional and longitudinal data from 1,109... Read More about Psychological Processes in Adapting to Dementia: Illness Representations Among the IDEAL Cohort.

Neurodegenerative brain changes are associated with area deprivation in the United Kingdom: findings from the Brains for Dementia Research study (2021)
Journal Article
Hamilton, C. A., Matthews, F. E., Erskine, D., Attems, J., & Thomas, A. J. (2021). Neurodegenerative brain changes are associated with area deprivation in the United Kingdom: findings from the Brains for Dementia Research study. Acta Neuropathologica Communications, 9(1), Article 198. https://doi.org/10.1186/s40478-021-01301-8

Socioeconomic disadvantage is associated with greater risk of dementia. This has been theorised to reflect inequalities in cognitive reserve, healthcare access, lifestyle, and other health factors which may contribute to the clinical manifestation of... Read More about Neurodegenerative brain changes are associated with area deprivation in the United Kingdom: findings from the Brains for Dementia Research study.

Can vaccination roll-out be more equitable if population risk is taken into account? (2021)
Journal Article
Sinclair, D. R., Maharani, A., Stow, D., Welsh, C. E., & Matthews, F. E. (2021). Can vaccination roll-out be more equitable if population risk is taken into account?. PLoS ONE, 16(November), Article e0259990. https://doi.org/10.1371/journal.pone.0259990

Background COVID-19 vaccination in many countries, including England, has been prioritised primarily by age. However, people of the same age can have very different health statuses. Frailty is a commonly used metric of health and has been found to be... Read More about Can vaccination roll-out be more equitable if population risk is taken into account?.

Slowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment (2021)
Journal Article
Hamilton, C. A., Schumacher, J., Matthews, F., Taylor, J. P., Allan, L., Barnett, N., …Thomas, A. J. (2021). Slowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment. International Psychogeriatrics, 33(12), 1321-1325. https://doi.org/10.1017/S1041610221001083

Electroencephalographic (EEG) abnormalities are greater in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB) than in MCI due to Alzheimer's disease (MCI-AD) and may anticipate the onset of dementia. We aimed to assess whether quantitative EEG... Read More about Slowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment.

The relationship between deprivation and frailty trajectories over 1 year and at the end of life: A case-control study (2021)
Journal Article
Stow, D., Hanratty, B., & Matthews, F. E. (2022). The relationship between deprivation and frailty trajectories over 1 year and at the end of life: A case-control study. Journal of Public Health, 44(4), 844-850. https://doi.org/10.1093/pubmed/fdab320

Background: We investigated the association between area-level, multi-domain deprivation and frailty trajectories in the last year of life and over 1 year in a matched non-end-of-life sample. Methods: A 1-year longitudinal case-control study using pr... Read More about The relationship between deprivation and frailty trajectories over 1 year and at the end of life: A case-control study.

National Early Warning Scores and COVID-19 deaths in care homes: An ecological time-series study (2021)
Journal Article
Stow, D., Barker, R. O., Matthews, F. E., & Hanratty, B. (2021). National Early Warning Scores and COVID-19 deaths in care homes: An ecological time-series study. BMJ open, 11(9), Article e045579. https://doi.org/10.1136/bmjopen-2020-045579

Objectives To investigate whether National Early Warning Scores (NEWS/NEWS2) could contribute to COVID-19 surveillance in care homes. Setting 460 care home units using the same software package to collect data on residents, from 46 local authority ar... Read More about National Early Warning Scores and COVID-19 deaths in care homes: An ecological time-series study.

The contribution of multiple long-term conditions to widening inequalities in disability-free life expectancy over two decades: Longitudinal analysis of two cohorts using the Cognitive Function and Ageing Studies (2021)
Journal Article
Bennett, H. Q., Kingston, A., Lourida, I., Robinson, L., Corner, L., Brayne, C. E., …Jagger, C. (2021). The contribution of multiple long-term conditions to widening inequalities in disability-free life expectancy over two decades: Longitudinal analysis of two cohorts using the Cognitive Function and Ageing Studies. EClinicalMedicine, 39, Article 101041. https://doi.org/10.1016/j.eclinm.2021.101041

Background:: Disability-free life expectancy (DFLE) inequalities by socioeconomic deprivation are widening, alongside rising prevalence of multiple long-term conditions (MLTCs). We use longitudinal data to assess whether MLTCs contribute to the widen... Read More about The contribution of multiple long-term conditions to widening inequalities in disability-free life expectancy over two decades: Longitudinal analysis of two cohorts using the Cognitive Function and Ageing Studies.

BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study (2021)
Journal Article
Rayner, F., Anderson, A. E., Baker, K. F., Buckley, C. D., Dyke, B., Fenton, S., …Isaacs, J. D. (2021). BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study. BMC Rheumatology, 5(1), Article 22. https://doi.org/10.1186/s41927-021-00194-3

Background: Our knowledge of immune-mediated inflammatory disease (IMID) aetiology and pathogenesis has improved greatly over recent years, however, very little is known of the factors that trigger disease relapses (flares), converting diseases from... Read More about BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study.

Developing and evaluating a frailty index for older South Africans - Findings from the HAALSI study (2021)
Journal Article
Barker, F. J., Davies, J. I., Xavier Gomez-Olive, F., Kahn, K., Matthews, F. E., Payne, C. F., …Witham, M. D. (2021). Developing and evaluating a frailty index for older South Africans - Findings from the HAALSI study. Age and ageing, 50(6), 2167-2173. https://doi.org/10.1093/ageing/afab111

Background: despite rapid population ageing, few studies have investigated frailty in older people in sub-Saharan Africa. We tested a cumulative deficit frailty index in a population of older people from rural South Africa. Methods: analysis of cross... Read More about Developing and evaluating a frailty index for older South Africans - Findings from the HAALSI study.

Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people-results from a nested, longitudinal cohort study (2021)
Journal Article
Richardson, S. J., Lawson, R., Davis, D. H., Stephan, B. C., Robinson, L., Matthews, F. E., …Allan, L. M. (2021). Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people-results from a nested, longitudinal cohort study. Age and ageing, 50(5), 1675-1681. https://doi.org/10.1093/ageing/afab068

Background: Acute hospitalisation and delirium have individually been shown to adversely affect trajectories of cognitive decline but have not previously been considered together. This work aimed to explore the impact on cognition of hospital admissi... Read More about Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people-results from a nested, longitudinal cohort study.

Progression to Dementia in Mild Cognitive Impairment with Lewy Bodies or Alzheimer Disease (2021)
Journal Article
Hamilton, C. A., Matthews, F. E., Donaghy, P. C., Taylor, J. P., O'Brien, J. T., Barnett, N., …Thomas, A. J. (2021). Progression to Dementia in Mild Cognitive Impairment with Lewy Bodies or Alzheimer Disease. Neurology, 96(22), E2685-E2693. https://doi.org/10.1212/WNL.0000000000012024

ObjectiveTo determine whether mild cognitive impairment with Lewy bodies or mild cognitive impairment with Alzheimer disease differ in their rates of clinical progression to dementia, we undertook longitudinal observation of mild cognitive impairment... Read More about Progression to Dementia in Mild Cognitive Impairment with Lewy Bodies or Alzheimer Disease.

Association of Race/Ethnicity and Social Disadvantage with Autism Prevalence in 7 Million School Children in England (2021)
Journal Article
Roman-Urrestarazu, A., Van Kessel, R., Allison, C., Matthews, F. E., Brayne, C., & Baron-Cohen, S. (2021). Association of Race/Ethnicity and Social Disadvantage with Autism Prevalence in 7 Million School Children in England. JAMA Pediatrics, 175(6), https://doi.org/10.1001/jamapediatrics.2021.0054

Importance: The global prevalence of autism spectrum disorder (ASD) has been reported to be between 1% and 2% of the population, with little research in Black, Asian, and other racial/ethnic minority groups. Accurate estimates of ASD prevalence are v... Read More about Association of Race/Ethnicity and Social Disadvantage with Autism Prevalence in 7 Million School Children in England.

Utility of the pareidolia test in mild cognitive impairment with Lewy bodies and Alzheimer's disease (2021)
Journal Article
Hamilton, C. A., Matthews, F. E., Allan, L. M., Barker, S., Ciafone, J., Donaghy, P. C., …Thomas, A. J. (2021). Utility of the pareidolia test in mild cognitive impairment with Lewy bodies and Alzheimer's disease. International journal of geriatric psychiatry, 36(9), 1407-1414. https://doi.org/10.1002/gps.5546

Objectives: Previous research has identified that dementia with Lewy bodies (DLB) has abnormal pareidolic responses which are associated with severity of visual hallucinations (VH), and the pareidolia test accurately classifies DLB with VH. We aimed... Read More about Utility of the pareidolia test in mild cognitive impairment with Lewy bodies and Alzheimer's disease.

Perceived and objective availability of green and blue spaces and quality of life in people with dementia: results from the IDEAL programme (2021)
Journal Article
Wu, Y. T., Clare, L., Jones, I. R., Nelis, S. M., Quinn, C., Martyr, A., …Matthews, F. E. (2021). Perceived and objective availability of green and blue spaces and quality of life in people with dementia: results from the IDEAL programme. Social Psychiatry and Psychiatric Epidemiology, 56(9), 1601-1610. https://doi.org/10.1007/s00127-021-02030-y

Purpose: The aim of this study was to investigate the associations between quality of life and both perceived and objective availability of local green and blue spaces in people with dementia, including potential variation across rural/urban settings... Read More about Perceived and objective availability of green and blue spaces and quality of life in people with dementia: results from the IDEAL programme.

Healthy ageing for all? Comparisons of socioeconomic inequalities in health expectancies over two decades in the Cognitive Function and Ageing Studies I and II (2021)
Journal Article
Bennett, H. Q., Kingston, A., Spiers, G., Robinson, L., Corner, L., Bambra, C., …Jagger, C. (2021). Healthy ageing for all? Comparisons of socioeconomic inequalities in health expectancies over two decades in the Cognitive Function and Ageing Studies I and II. International Journal of Epidemiology, 50(3), 841-851. https://doi.org/10.1093/ije/dyaa271

Background: Despite increasing life expectancy (LE), cross-sectional data show widening inequalities in disability-free LE (DFLE) by socioeconomic status (SES) in many countries. We use longitudinal data to better understand trends in DFLE and years... Read More about Healthy ageing for all? Comparisons of socioeconomic inequalities in health expectancies over two decades in the Cognitive Function and Ageing Studies I and II.

Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain (2021)
Journal Article
Bury, J. J., Chambers, A., Heath, P. R., Ince, P. G., Shaw, P. J., Matthews, F. E., …Wharton, S. B. (2021). Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain. Acta Neuropathologica Communications, 9(1), Article 5. https://doi.org/10.1186/s40478-020-01109-y

Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit. In this s... Read More about Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain.

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