All Outputs (2)

Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide (2021)
Journal Article
Aronoff, M. R., Hiebert, P., Hentzen, N. B., Werner, S., & Wennemers, H. (2021). Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide. Nature Chemical Biology, 17(8), 865-871. https://doi.org/10.1038/s41589-021-00830-6

Collagens are fibrous proteins that are integral to the strength and stability of connective tissues. During collagen maturation, lysyl oxidases (LOX) initiate the cross-linking of fibers, but abnormal LOX activity is associated with impaired tissue... Read More about Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide.

The Nrf2 transcription factor: A multifaceted regulator of the extracellular matrix (2021)
Journal Article
Hiebert, P. (2021). The Nrf2 transcription factor: A multifaceted regulator of the extracellular matrix. Matrix Biology Plus, 10, Article 100057. https://doi.org/10.1016/j.mbplus.2021.100057

The transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) is widely recognized as a master regulator of the cellular stress response by facilitating the transcription of cytoprotective genes. As such, the Nrf2 pathway is critical in... Read More about The Nrf2 transcription factor: A multifaceted regulator of the extracellular matrix.