Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain

Simpson, J. E.; Ince, P. G.; Haynes, L. J.; Theaker, R.; Gelsthorpe, C.; Baxter, L.; Forster, G.; Lace, G. L.; Shaw, P. J.; Matthews, F. E.; Savva, G. M.; Brayne, C.; Wharton, S. B.

doi:10.1111/j.1365-2990.2009.01030.x

All Outputs (2)

Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain (2013)
Journal Article
Garwood, C., Faizullabhoy, A., Wharton, S. B., Ince, P. G., Heath, P. R., Shaw, P. J., …Simpson, J. E. (2013). Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain. Neuropathology and Applied Neurobiology, 39(7), 788-799. https://doi.org/10.1111/nan.12033

Aims: Calcium dyshomeostasis is implicated in the pathogenesis of several neurodegenerative disorders including Alzheimer's disease. However, much of the previous research has focused on changes in neuronal calcium signalling. In a recent microarray... Read More about Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain.

Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain (2010)
Journal Article
Simpson, J. E., Ince, P. G., Haynes, L. J., Theaker, R., Gelsthorpe, C., Baxter, L., …Wharton, S. B. (2010). Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathology and Applied Neurobiology, 36(1), 25-40. https://doi.org/10.1111/j.1365-2990.2009.01030.x

Aims: Increasing evidence suggests a role for oxidative damage to DNA in brain ageing and in neurodegenerative disorders, including Alzheimer's disease. Most studies have focussed on the reduced capacity for DNA repair by neurones, and have not taken... Read More about Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.