All Outputs (17)

Applications of radiation in photodiagnosis and photodynamic therapy (2020)
Thesis
Entract, G. (2020). Applications of radiation in photodiagnosis and photodynamic therapy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222353

The application of radiation to porphyrin-based photosensitisers for the purposes of photodiagnosis and photodynamic therapy have been described in an effort to explore combined therapies, which seek to extend the use of photodynamic therapy beyond i... Read More about Applications of radiation in photodiagnosis and photodynamic therapy.

Porphyrin and metalloporphyrin agents for the personalised treatment and imaging of cancers (2019)
Thesis
Sandland, J. (2019). Porphyrin and metalloporphyrin agents for the personalised treatment and imaging of cancers. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4398472

The improvement of cancer medicine by utilizing the approach of personalised medicine has been investigated, principally, through the combination of diagnostic imaging (PET imaging) with treatment modalities (radiotherapy). Radiotherapy is key to bot... Read More about Porphyrin and metalloporphyrin agents for the personalised treatment and imaging of cancers.

Theranostic porphyrin conjugates for the combined treatment and diagnosis of cancer (2019)
Thesis
Yap, S. Y. (2019). Theranostic porphyrin conjugates for the combined treatment and diagnosis of cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4221753

The development of theranostic agents capable of the combined treatment of diagnosis of disease has seen a growing interest within the research community. The combination of diagnostic and treatment modality onto a single construct will allow the car... Read More about Theranostic porphyrin conjugates for the combined treatment and diagnosis of cancer.

Near infrared fluorescence probes : towards applications in fluorescence guided surgery (2017)
Thesis
Cheng, H. Y. (2017). Near infrared fluorescence probes : towards applications in fluorescence guided surgery. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4220740

Surgery has been a popular method for the treatment of cancers, in particular solid tumours; but the surgical margins for cancerous tissues are often indistinct and in most cases, the poor identification of residual cancer tissues can result in re-ex... Read More about Near infrared fluorescence probes : towards applications in fluorescence guided surgery.

Self-sterilising surfaces to combat healthcare associated infections (2017)
Thesis
Turner, C. L. (2017). Self-sterilising surfaces to combat healthcare associated infections. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4266419

The immobilisation of photosensitisers on polymeric supports for use in photodynamic antimicrobial chemotherapy has become increasingly popular. The immobilisation of photosensitisers on polymeric supports has been attempted previously by covalent at... Read More about Self-sterilising surfaces to combat healthcare associated infections.

A microfluidic approach to the study of cellular responses to oxidative stress (2015)
Thesis
Chandrabalan, K. (2015). A microfluidic approach to the study of cellular responses to oxidative stress. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4217617

Synthesis of water-soluble porphyrin-dendron conjugates for targeted photodynamic therapy (2013)
Thesis
Bryden, F. (2013). Synthesis of water-soluble porphyrin-dendron conjugates for targeted photodynamic therapy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4221329

The targeting of photosensitisers with tumour-associated biomolecules is widely used for improved photosensitiser tumour localisation during photodynamic therapy, allowing fewer side effects in comparison to conventional cancer treatments. In particu... Read More about Synthesis of water-soluble porphyrin-dendron conjugates for targeted photodynamic therapy.

Towards the synthesis of multifunctional constructs : coupling PET and PDT for the targeted diagnosis and therapy of CXCR4 expressing tumours (2012)
Thesis
Smith, R. (2012). Towards the synthesis of multifunctional constructs : coupling PET and PDT for the targeted diagnosis and therapy of CXCR4 expressing tumours. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4219918

To establish accurate and early stage tumour diagnosis, quantitative molecular imaging modalities such as positron emission tomography (PET) are being employed. Molecular probes containing a positron emitting isotope (e.g. ¹⁸F, ⁶⁴Cu) are designed to... Read More about Towards the synthesis of multifunctional constructs : coupling PET and PDT for the targeted diagnosis and therapy of CXCR4 expressing tumours.

Development of a microfluidic device for the in situ production of singlet oxygen for chemical and biological applications (2012)
Thesis
Lumley, E. K. (2012). Development of a microfluidic device for the in situ production of singlet oxygen for chemical and biological applications. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4219891

Cancer cells are derived from cells that are termed, and recognised as being 'self', meaning that the immune system does not target them. Many treatments target the tumour through its requirement for large quantities of nutrients. However, this cause... Read More about Development of a microfluidic device for the in situ production of singlet oxygen for chemical and biological applications.

Polyacrylamide nanoparticle delivery systems in photodynamic therapy (2011)
Thesis
Kuruppuarachchi, M. (2011). Polyacrylamide nanoparticle delivery systems in photodynamic therapy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4213126

In treating many diseases, including cancer and bacterial infections, drug resistance has emerged as a major obstacle limiting the therapeutic efficacy of chemotherapeutic agents. One area which may prove to be particularly attractive is Photodynamic... Read More about Polyacrylamide nanoparticle delivery systems in photodynamic therapy.

Development of porphyrin-antiangiogenic antibody immunoconjugates for photodynamic therapy (2010)
Thesis
Bullous, A. (2010). Development of porphyrin-antiangiogenic antibody immunoconjugates for photodynamic therapy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4211381

Photodynamic therapy is a novel cancer treatment, involving the combination of light, photosensitiser and molecular oxygen to produce cytotoxic species. Currently, commercially available photosensitisers, including Photofrin and Foscan, only exhibit... Read More about Development of porphyrin-antiangiogenic antibody immunoconjugates for photodynamic therapy.

Dipyrrin complexes and their uses as self assembling materials (2010)
Thesis
Benstead, M. (2010). Dipyrrin complexes and their uses as self assembling materials. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4210942

Several series of BODIPYs bearing mesogenic substituents were synthesised and their fluorescence and liquid crystal properties were characterized. Each compound prepared consisted of one BODIPY fluorophore and one, two or three mesogenic units based... Read More about Dipyrrin complexes and their uses as self assembling materials.

Synthesis of tetraazamacrocyclic complexes: Biomedical applications (2009)
Thesis
Mewis, R. E. (2009). Synthesis of tetraazamacrocyclic complexes: Biomedical applications. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4208988

Tetraazamacrocyclic frameworks of 1,4,7,10-tetraazacylcododecane (cyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam) with functional pendent arms and porphyrins with solubilising polyethylene glycol (PEG) chains have been synthesised. The pendent... Read More about Synthesis of tetraazamacrocyclic complexes: Biomedical applications.

The synthesis of cationic porphyrins for use in photodynamic antimicrobial chemotherapy (PACT (2008)
Thesis
Hall, C. E. (2008). The synthesis of cationic porphyrins for use in photodynamic antimicrobial chemotherapy (PACT. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4212816

Photodynamic therapy (PDT) has been widely used in recent years for the treatment of cancers. However the growing problem of drug resistance in bacteria has led to PDT being used to treat bacterial infections in a new type of therapy called Photodyna... Read More about The synthesis of cationic porphyrins for use in photodynamic antimicrobial chemotherapy (PACT.

Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer (2008)
Thesis
Welch, C. J. (2008). Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4208906

Porphyrin molecules are efficient generators of singlet oxygen and are used as photosensitisers in PDT. They are also known to accumulate in tumour tissue due to the hyperpermeability of tumour vasculature and poor lymphatic drainage, thus exhibiting... Read More about Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer.

Porphyrin-nanosensor conjugates : novel tools for the study of cellular response to oxidative stress (2007)
Thesis
Josefsen, L. B. (2007). Porphyrin-nanosensor conjugates : novel tools for the study of cellular response to oxidative stress. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4217734

The cellular environment is heterogeneous in nature and home to a multitude of species and reactions. If the labyrinth behind these reactions and signaling pathways (along with those leading to cell death) can be decoded it may be possible to identif... Read More about Porphyrin-nanosensor conjugates : novel tools for the study of cellular response to oxidative stress.

Synthesis of porphyrins and metalloporphyrins for biological applications (2005)
Thesis
Ita, S. (2005). Synthesis of porphyrins and metalloporphyrins for biological applications. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4221109

Porphyrins are ideal candidates for PDT (Photodynamic therapy). Their ability to localise preferentially in diseased tissue allows specific targeting of cancerous tissue in certain areas. In recent years, linking photosensitisers to sugar moieties ha... Read More about Synthesis of porphyrins and metalloporphyrins for biological applications.