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All Outputs (31)

Establishing a novel 3-dimensional microfluidic model of bunyavirus Infection to characterise exosome release from tumour cells (2022)
Thesis
Marsh, D. (2022). Establishing a novel 3-dimensional microfluidic model of bunyavirus Infection to characterise exosome release from tumour cells. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4224638

The order Bunyavirales represents the largest and most diverse taxonomic grouping of negative-sense RNA viruses, some of which are associated with significant diseases in humans and livestock. The global emergence of these viruses is exacerbated by t... Read More about Establishing a novel 3-dimensional microfluidic model of bunyavirus Infection to characterise exosome release from tumour cells.

Establishing a flow-based system for repressing target gene expression in a microfluidic device using a glioblastoma spheroid model (2022)
Thesis
Hosni Ep Ben Daoud, I. (2022). Establishing a flow-based system for repressing target gene expression in a microfluidic device using a glioblastoma spheroid model. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4224543

Glioblastoma (GBM) is a deadly disease with poor prognosis. The gold standard treatment is surgery followed by chemoradiotherapy almost always including Temozolomide. Despite extensive research for new therapeutic approaches relapse after treatment s... Read More about Establishing a flow-based system for repressing target gene expression in a microfluidic device using a glioblastoma spheroid model.

Investigating the role of arginine methylation in glioblastoma using biomicrofluidics (2021)
Thesis
Samuel, S. F. (2021). Investigating the role of arginine methylation in glioblastoma using biomicrofluidics. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4223865

Despite intense research, the prognosis of patients with glioblastoma (GBM) remains extremely poor, with a median survival of 1.5 years after diagnosis. The need for new therapeutic options is therefore a vital step towards securing a better outlook... Read More about Investigating the role of arginine methylation in glioblastoma using biomicrofluidics.

An investigation of the regulatory mechanisms of cellular homeostasis and haemostasis initiated by tissue factor (2020)
Thesis
Mohammad, M. A. (2020). An investigation of the regulatory mechanisms of cellular homeostasis and haemostasis initiated by tissue factor. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222998

The signalling arising from tissue factor (TF) has been associated with cellular homeostasis as well as haemostasis and, is particularly pertinent in carcinogenesis and cancer progression. The formation of the TF-FVIIa complex is known to activate pr... Read More about An investigation of the regulatory mechanisms of cellular homeostasis and haemostasis initiated by tissue factor.

Development of a dual flow microfluidic device for the study of barrier systems (2020)
Thesis
Baldwin, L. (2020). Development of a dual flow microfluidic device for the study of barrier systems. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4223404

Inflammatory Bowel Diseases (IBD) including Crohn’s Disease and Ulcerative Colitis are chronic conditions characterised by inflammation of the wall of the gastrointestinal tract. IBD has also been shown to have systemic impacts including on the centr... Read More about Development of a dual flow microfluidic device for the study of barrier systems.

Applications of microfluidics system for evaluating the biology of glioblastoma tissue and testing response to chemotherapy (2019)
Thesis
Olubajo, F. O. (2019). Applications of microfluidics system for evaluating the biology of glioblastoma tissue and testing response to chemotherapy. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4221522

The genetic and molecular variations that exist within Glioblastoma (GBM) tumours determine treatment responses. One way to improve patient outcomes is to optimise treatment(s) pre-clinically by studying each tumour on an individual basis. Present... Read More about Applications of microfluidics system for evaluating the biology of glioblastoma tissue and testing response to chemotherapy.

Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei (2018)
Thesis
Alshegifi, M. (2018). Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4221223

Trypanosoma brucei is a medically important protozoan parasite that causes African sleeping sickness in humans. Although disease treatment is possible, it is hindered by the limited availability of effective drugs and the rapid emergence of drug resi... Read More about Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei.

Elucidation of the signalling mechanisms involved in TF-mediated apoptosis in endothelial cells (2018)
Thesis
Ethaeb, A. M. (2018). Elucidation of the signalling mechanisms involved in TF-mediated apoptosis in endothelial cells. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4220989

Tissue factor (TF) is the main initiator of blood coagulation. In addition to its procoagulant property, TF has the ability to regulate various functions within cells including proliferation, angiogenesis and apoptosis. These outcomes appear to depen... Read More about Elucidation of the signalling mechanisms involved in TF-mediated apoptosis in endothelial cells.

Targeted activation of dendritic cells via the CD40 receptor (2018)
Thesis
Wingham, B. (2018). Targeted activation of dendritic cells via the CD40 receptor. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4224089

Dendritic cell (DC) activation underpins the patient immune response in multiple cancers, including ovarian cancer. While DCs are detected within the margins of ovarian tumours, DC populations are maintained in an immature state, displaying low level... Read More about Targeted activation of dendritic cells via the CD40 receptor.

The generation of an immunosuppressive microenvironment by soluble factors in head and neck squamous cell carcinoma (2018)
Thesis
Roberts, E. R. (2018). The generation of an immunosuppressive microenvironment by soluble factors in head and neck squamous cell carcinoma. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4220880

Tumour infiltrating lymphocytes (TIL) in head neck squamous cell carcinoma (HNSCC) are enriched in Treg, a finding confirmed in the current study, which is thought to be a contributing factor to immunosuppression and tumour evasion. Soluble factors r... Read More about The generation of an immunosuppressive microenvironment by soluble factors in head and neck squamous cell carcinoma.

Regulation of hypoxia responsive gene expression by specificity protein family transcription factors in breast cancer (2017)
Thesis
Wijesinghe, N. P. (2017). Regulation of hypoxia responsive gene expression by specificity protein family transcription factors in breast cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4221147

Cancer accounts for the highest amounts of disease related premature deaths worldwide with 8.1 million of deaths being associated with malignancy. In the cancer microenvironment, particularly in solid tumours, hypoxia plays a significant role in prog... Read More about Regulation of hypoxia responsive gene expression by specificity protein family transcription factors in breast cancer.

Monitoring the response of head and neck tumour tissue to irradiation using a microfluidic-based approach (2016)
Thesis
Cheah, R. (2016). Monitoring the response of head and neck tumour tissue to irradiation using a microfluidic-based approach. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4218576

Radiotherapy remains the standard treat74ment for head and neck squamous cell carcinoma (HNSCC), however, resistance remains a real clinical problem despite the improvements and development of new treatment strategies. Patient outcome could potential... Read More about Monitoring the response of head and neck tumour tissue to irradiation using a microfluidic-based approach.

Role of hypoxia-induced ADAM 10 in colorectal cancer progression (2016)
Thesis
Todd, A. E. (2016). Role of hypoxia-induced ADAM 10 in colorectal cancer progression. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4219363

Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and is the second deadliest form of cancer within the UK. The majority of CRC arises sporadically, as a result of epigenetic alterations transforming normal epithelium to malignan... Read More about Role of hypoxia-induced ADAM 10 in colorectal cancer progression.

Investigating the role of WSB-1 in breast cancer (2016)
Thesis
Poujade, F. (2016). Investigating the role of WSB-1 in breast cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4219511

Breast cancer is the second most represented cancer type worldwide and will affect 1 in 8 women in the UK. Overall patient survival can reach 90% when the disease is diagnosed early but rapidly drops as the tumour progresses and metastasises. The ste... Read More about Investigating the role of WSB-1 in breast cancer.

An observational pilot study to assess the potential of a microfluidic tissue culture model to predict rectal cancer response to neo-adjuvant therapy (2016)
Thesis
Patel, R. (2016). An observational pilot study to assess the potential of a microfluidic tissue culture model to predict rectal cancer response to neo-adjuvant therapy. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4218991

Radiotherapy has been reported to induce apoptosis and prevent the proliferation of malignant cells. Complete clinical response to neo-adjuvant long course chemoradiotherapy has been identified in up to 30% of patients with locally advanced rectal ca... Read More about An observational pilot study to assess the potential of a microfluidic tissue culture model to predict rectal cancer response to neo-adjuvant therapy.

The effect of HNSCC-derived soluble factors on the proliferation and function of immune cells (2016)
Thesis
Smith, J. D. (2016). The effect of HNSCC-derived soluble factors on the proliferation and function of immune cells. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4219345

Malignant epithelium and associated stromal cells secrete soluble factors which may influence tumour evasion of host immunity. The effect of these factors on the proliferation and function of individual immune cell populations has been investigated a... Read More about The effect of HNSCC-derived soluble factors on the proliferation and function of immune cells.

Synthesis and biological evaluation of CXCR4 chemokine receptor antagonists (2014)
Thesis
Nicholson, K. L. (2014). Synthesis and biological evaluation of CXCR4 chemokine receptor antagonists. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222198

The CXCR4 chemokine receptor is known to be overexpressed in many types of cancer as well as being involved in several stages of metastasis, which is responsible for the majority of deaths in cancer patients. Molecular imaging techniques, such as pos... Read More about Synthesis and biological evaluation of CXCR4 chemokine receptor antagonists.

From bench to bedside : the development of a location indicating nasogastric tube (2014)
Thesis
Elliott, B. E. (2014). From bench to bedside : the development of a location indicating nasogastric tube. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4223996

Background Nasogastric tubes are frequently used in clinical practice. Correct placement in the stomach must be verified on passing the tube and before every feed or administration of medicine. Current methods of confirming placement are limited and... Read More about From bench to bedside : the development of a location indicating nasogastric tube.

The development of nuclear receptor imaging agents (2014)
Thesis
Allott, L. (2014). The development of nuclear receptor imaging agents. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4217221

Positron emission tomography (PET) is a molecular imaging technique which allows visualisation and quantification of biomarkers by administering a positron-emitting molecular probe. The steroid hormone receptors for estrogen and progesterone are over... Read More about The development of nuclear receptor imaging agents.