Skip to main content

Research Repository

Advanced Search

All Outputs (4)

Development of a multimodal imaging probe for detecting aggressive prostate cancer (2020)
Thesis
Clarke, M. T. (2020). Development of a multimodal imaging probe for detecting aggressive prostate cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4223251

This thesis reports on the synthesis, development and validation of a novel, non-toxic dual modal bio-imaging probe that targets a conformational molecular switch and relocalisation of cell surface Endo180 into endosomes that occurs during the early... Read More about Development of a multimodal imaging probe for detecting aggressive prostate cancer.

The development of a multimodal imaging agent for the management of diabetes mellitus type 2 (2019)
Thesis
Garrod, A. J. (2019). The development of a multimodal imaging agent for the management of diabetes mellitus type 2. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4221898

Diabetes Mellitus is a metabolic disorder with multiple aetiologies with an estimated 422 million people with the condition, which is characterised by the chronic presence of hyperglycaemia and dysfunction in carbohydrate, protein, and fat metabolism... Read More about The development of a multimodal imaging agent for the management of diabetes mellitus type 2.

The synthesis and validation of multimodal PET/fluorescence zinc sensing probes as potential imaging agents for prostate cancer (2017)
Thesis
Firth, G. (2017). The synthesis and validation of multimodal PET/fluorescence zinc sensing probes as potential imaging agents for prostate cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4221824

Prostate cancer (PCa) is the 2nd most common cancer worldwide for males, and the 4th most common cancer overall, accounting for 15% of all male cancers in 2012. PCa is asymptomatic in its early stages, advances in medical imaging are improving diagno... Read More about The synthesis and validation of multimodal PET/fluorescence zinc sensing probes as potential imaging agents for prostate cancer.

Investigating the biological and clinical implications of Endo180 in breast cancer (2017)
Thesis
Wang, K. (2017). Investigating the biological and clinical implications of Endo180 in breast cancer. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222284

Endo180 is a 180 kDa type-1 transmembrane receptor that belongs to the mannose receptor family and interacts with extracellular / intracellular collagens. Endo180 expression is correlated with tumour grade, disease progression and poor prognosis in s... Read More about Investigating the biological and clinical implications of Endo180 in breast cancer.