All Outputs (3)

Mathematical Model of Clonal Evolution Proposes a Personalised Multi-Modal Therapy for High-Risk Neuroblastoma (2023)
Journal Article
Italia, M., Wertheim, K. Y., Taschner-Mandl, S., Walker, D., & Dercole, F. (2023). Mathematical Model of Clonal Evolution Proposes a Personalised Multi-Modal Therapy for High-Risk Neuroblastoma. Cancers, 15(7), Article 1986. https://doi.org/10.3390/cancers15071986

Neuroblastoma is the most common extra-cranial solid tumour in children. Despite multi-modal therapy, over half of the high-risk patients will succumb. One contributing factor is the one-size-fits-all nature of multi-modal therapy. For example, durin... Read More about Mathematical Model of Clonal Evolution Proposes a Personalised Multi-Modal Therapy for High-Risk Neuroblastoma.

A theoretical analysis of the scale separation in a model to predict solid tumour growth (2022)
Journal Article
de Melo Quintela, B., Hervas-Raluy, S., Garcia-Aznar, J. M., Walker, D., Wertheim, K. Y., & Viceconti, M. (2022). A theoretical analysis of the scale separation in a model to predict solid tumour growth. Journal of Theoretical Biology, 547, Article 111173. https://doi.org/10.1016/j.jtbi.2022.111173

Solid tumour growth depends on a host of factors which affect the cell life cycle and extracellular matrix vascularization that leads to a favourable environment. The whole solid tumour can either grow or wither in response to the action of the immun... Read More about A theoretical analysis of the scale separation in a model to predict solid tumour growth.

PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers (2020)
Journal Article
Martí-Bonmatí, L., Alberich-Bayarri, Á., Ladenstein, R., Blanquer, I., Segrelles, J. D., Cerdá-Alberich, L., …Neri, E. (2020). PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers. European Radiology Experimental, 4(1), https://doi.org/10.1186/s41747-020-00150-9

PRIMAGE is one of the largest and more ambitious research projects dealing with medical imaging, artificial intelligence and cancer treatment in children. It is a 4-year European Commission-financed project that has 16 European partners in the consor... Read More about PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers.