CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and aurora A

Cazares-Körner, Cindy; Pires, Isabel M.; Swallow, I. Diane; Grayer, Samuel C.; O'Connor, Liam J.; Olcina, Monica M.; Christlieb, Martin; Conway, Stuart J.; Hammond, Ester M.

doi:10.1021/cb4001537

All Outputs (3)

The role of WSB-1 as a BRCAness biomarker in breast cancer (2023)
Thesis
Li, . C. (2023). The role of WSB-1 as a BRCAness biomarker in breast cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4436228

Background
Radiotherapy currently has become one of the major therapeutic approaches in the treatments for cancers. However, hypoxia presents a significant challenge to the effectiveness of radiotherapy and is associated with radio-resistance. Previ... Read More about The role of WSB-1 as a BRCAness biomarker in breast cancer.

Signaling by PTK6 (2016)
Journal Article
Orlic-Milacic, M., & Pires, I. (2016). Signaling by PTK6. Reactome a knowledgebase of biological processes, 56, https://doi.org/10.3180/r-hsa-8848021.1

CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and aurora A (2013)
Journal Article
Cazares-Körner, C., Pires, I. M., Swallow, I. D., Grayer, S. C., O'Connor, L. J., Olcina, M. M., Christlieb, M., Conway, S. J., & Hammond, E. M. (2013). CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and aurora A. ACS Chemical Biology, 8(7), 1451-1459. https://doi.org/10.1021/cb4001537

The increased resistance of hypoxic cells to all forms of cancer therapy presents a major barrier to the successful treatment of most solid tumors. Inhibition of the essential kinase Checkpoint kinase 1 (Chk1) has been described as a promising cancer... Read More about CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and aurora A.