A new model for prediction of drug distribution in tumor and normal tissues: Pharmacokinetics of temozolomide in glioma patients
(2009)
Journal Article
Rosso, L., Brock, C. S., Gallo, J. M., Saleem, A., Price, P. M., Turkheimer, F. E., & Aboagye, E. O. (2009). A new model for prediction of drug distribution in tumor and normal tissues: Pharmacokinetics of temozolomide in glioma patients. Cancer Research, 69(1), 120-127. https://doi.org/10.1158/0008-5472.CAN-08-2356
Difficulties in direct measurement of drug concentrations in human tissues have hampered the understanding of drug accumulation in tumors and normal tissues. We propose a new system analysis modeling approach to characterize drug distribution in tiss... Read More about A new model for prediction of drug distribution in tumor and normal tissues: Pharmacokinetics of temozolomide in glioma patients.