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Preparation of cationic cobalt phenoxide and ethoxide complexes and their reversible reaction with carbon dioxide (2002)
Journal Article
Archibald, S. J., Foxon, S. P., Freeman, J. D., Hobson, J. E., Perutz, R. N., & Walton, P. H. (2002). Preparation of cationic cobalt phenoxide and ethoxide complexes and their reversible reaction with carbon dioxide. Dalton Transactions : an international journal of inorganic chemistry, 2797-2799. https://doi.org/10.1039/b204560e

The complexes [Co(TCT)(OR)]BPh4 (R = Et, Ph; TCT = cis,cis-1,3,5-tris(cinnamylideneamino)cyclohexane) have been prepared and characterised by X-ray diffraction; in coordinating solvents both complexes react reversibly with carbon dioxide to form orga... Read More about Preparation of cationic cobalt phenoxide and ethoxide complexes and their reversible reaction with carbon dioxide.

Lanthanoid complexes of a tripodal acetal ligand: Synthesis, structural characterisation and reactivity with 3d metals (1997)
Journal Article
Archibald, S. J., Blake, A. J., Parsons, S., Schröder, M., & Winpenny, R. E. (1997). Lanthanoid complexes of a tripodal acetal ligand: Synthesis, structural characterisation and reactivity with 3d metals. Journal of the Chemical Society. Dalton Transactions, 173-179. https://doi.org/10.1039/a605154e

A novel tripodal ligand (H3L1) has been prepared by condensation of tris(2-aminoethyl)amine with 2,6-diformyl-4-methylphenol in MeOH. The compound has three equivalent side-arms, each containing four possible donor groups, an imine N atom, a phenol O... Read More about Lanthanoid complexes of a tripodal acetal ligand: Synthesis, structural characterisation and reactivity with 3d metals.

Synthesis and characterization of functionalized N,N′-diphenylformamidinate silver(I) dimers: Solid-state structures and solution properties (1999)
Journal Article
Archibald, S. J. (1999). Synthesis and characterization of functionalized N,N′-diphenylformamidinate silver(I) dimers: Solid-state structures and solution properties. Inorganic chemistry, 38(24), 5571-5578. https://doi.org/10.1021/ic981270%2B

Functionalized N,N′-diphenylformamidines and their deprotonated silver(I) complexes have been synthesized: silver(I) N,N′-di(4-alkyl)phenylformamidinate (alkyl = methyl, ethyl, n-butyl, and n-hexadecyl) 1-4; silver(I) N,N′-di(4-trifluorometnyl)phenyl... Read More about Synthesis and characterization of functionalized N,N′-diphenylformamidinate silver(I) dimers: Solid-state structures and solution properties.

Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge (2019)
Journal Article
Erritzoe, D., Ashok, A. H., Searle, G. E., Colasanti, A., Turton, S., Lewis, Y., Huiban, M., Moz, S., Passchier, J., Saleem, A., Beaver, J., Lingford-Hughes, A., Nutt, D. J., Howes, O. D., Gunn, R. N., Knudsen, G. M., & Rabiner, E. A. (2020). Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge. Neuropsychopharmacology, 45(5), 804-810. https://doi.org/10.1038/s41386-019-0567-5

© 2019, The Author(s), under exclusive licence to American College of Neuropsychopharmacology. Positron emission tomography (PET) enables non-invasive estimation of neurotransmitter fluctuations in the living human brain. While these methods have bee... Read More about Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge.

A study of the focal adhesion kinase inhibitor GSK2256098 in patients with recurrent glioblastoma with evaluation of tumor penetration of [ 11 C]GSK2256098 (2018)
Journal Article
Brown, N. F., Williams, M., Arkenau, H. T., Fleming, R. A., Tolson, J., Yan, L., Zhang, J., Swartz, L., Singh, R., Auger, K. R., Lenox, L., Cox, D., Lewis, Y., Plisson, C., Searle, G., Saleem, A., Blagden, S., & Mulholland, P. (2018). A study of the focal adhesion kinase inhibitor GSK2256098 in patients with recurrent glioblastoma with evaluation of tumor penetration of [ 11 C]GSK2256098. Neuro-Oncology, 20(12), 1634-1642. https://doi.org/10.1093/neuonc/noy078

© The Author(s) 2018. Background GSK2256098 is a novel oral focal adhesion kinase (FAK) inhibitor. Preclinical studies demonstrate growth inhibition in glioblastoma cell lines. However, rodent studies indicate limited blood-brain barrier (BBB) penetr... Read More about A study of the focal adhesion kinase inhibitor GSK2256098 in patients with recurrent glioblastoma with evaluation of tumor penetration of [ 11 C]GSK2256098.

Erratum to: Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer (EJNMMI Research, (2015), 5, 1, (30), 10.1186/s13550-015-0103-5) (2017)
Journal Article
Saleem, A., Searle, G. E., Kenny, L. M., Huiban, M., Kozlowski, K., Waldman, A. D., Woodley, L., Palmieri, C., Lowdell, C., Kaneko, T., Murphy, P. S., Lau, M. R., Aboagye, E. O., & Coombes, R. C. (2017). Erratum to: Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer (EJNMMI Research, (2015), 5, 1, (30), 10.1186/s13550-015-0103-5). EJNMMI Research, 7, https://doi.org/10.1186/s13550-017-0325-9

© 2017, The Author(s). Following publication of the original article [1], the authors have become aware that there is an error in the description of the image data in the legend to Fig. 5. The second sentence of the legend should read as follows: “Th... Read More about Erratum to: Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer (EJNMMI Research, (2015), 5, 1, (30), 10.1186/s13550-015-0103-5).

Erratum to: Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer (EJNMMI Res., (2015), 5, (30), 10.1186/s13550-015-0103-5) (2017)
Journal Article
Saleem, A., Searle, G. E., Kenny, L. M., Huiban, M., Kozlowski, K., Waldman, A. D., Woodley, L., Palmieri, C., Lowdell, C., Kaneko, T., Murphy, P. S., Lau, M. R., Aboagye, E. O., & Coombes, R. C. (2017). Erratum to: Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer (EJNMMI Res., (2015), 5, (30), 10.1186/s13550-015-0103-5). EJNMMI Research, 7, https://doi.org/10.1186/s13550-017-0323-y

© 2017, The Author(s). Since publication of their article [1], the authors have become aware that there is an error in the description of the image data in the legend to Fig. 5. The second sentence of the legend should read as follows: “The image dat... Read More about Erratum to: Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer (EJNMMI Res., (2015), 5, (30), 10.1186/s13550-015-0103-5).

Diagnostic and therapeutic imaging in oncology (2016)
Journal Article
Rembielak, A., Green, M., Saleem, A., & Price, P. (2016). Diagnostic and therapeutic imaging in oncology. Medicine, 44(1), 6-9. https://doi.org/10.1016/j.mpmed.2015.10.010

© 2015 Elsevier Ltd. All rights reserved. Medical imaging techniques are an important element in early detection for many cancers. They are also essential for determining the location, extension and stage of the lesion in diagnosis, for guiding treat... Read More about Diagnostic and therapeutic imaging in oncology.

Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer (2015)
Journal Article
Saleem, A., Searle, G. E., Kenny, L. M., Huiban, M., Kozlowski, K., Waldman, A. D., Woodley, L., Palmieri, C., Lowdell, C., Kaneko, T., Murphy, P. S., Lau, M. R., Aboagye, E. O., & Coombes, R. C. (2015). Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer. EJNMMI Research, 5(1), https://doi.org/10.1186/s13550-015-0103-5

© 2015, Saleem et al.; licensee Springer. Background: Brain metastases are common in human epidermal growth factor receptor (Her)-2-positive breast cancer. Drug access to brain metastases and normal brain is key to management of cranial disease. In t... Read More about Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer.

Dose-finding quantitative 18F-FDG PET imaging study with the oral Pan-AKT inhibitor GSK2141795 in patients with gynecologic malignancies (2015)
Journal Article
Gungor, H., Saleem, A., Babar, S., Dina, R., El-Bahrawy, M. A., Curry, E., Rama, N., Chen, M., Pickford, E., Agarwal, R., Blagden, S., Carme, S., Salinas, C., Madison, S., Krachey, E., Santiago-Walker, A., Smith, D. A., Morris, S. R., Stronach, E. A., & Gabra, H. (2015). Dose-finding quantitative 18F-FDG PET imaging study with the oral Pan-AKT inhibitor GSK2141795 in patients with gynecologic malignancies. Journal of nuclear medicine, 56(12), 1828-1835. https://doi.org/10.2967/jnumed.115.156505

© 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc. AKT (a serine/threonine-specific protein kinase) regulates many cellular processes contributing to cytotoxic drug resistance. This study's primary objective examined the relationsh... Read More about Dose-finding quantitative 18F-FDG PET imaging study with the oral Pan-AKT inhibitor GSK2141795 in patients with gynecologic malignancies.

A putative biomarker signature for clinically effective AKT inhibition: Correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway (2015)
Journal Article
Cheraghchi-Bashi, A., Parker, C. A., Curry, E., Salazar, J. F., Gungor, H., Saleem, A., Cunnea, P., Rama, N., Salinas, C., Mills, G. B., Morris, S. R., Kumar, R., Gabra, H., & Stronach, E. A. (2015). A putative biomarker signature for clinically effective AKT inhibition: Correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway. Oncotarget, 6(39), 41736-41749. https://doi.org/10.18632/oncotarget.6153

Our identification of dysregulation of the AKT pathway in ovarian cancer as a platinum resistance specific event led to a comprehensive analysis of in vitro, in vivo and clinical behaviour of the AKT inhibitor GSK2141795. Proteomic biomarker signatur... Read More about A putative biomarker signature for clinically effective AKT inhibition: Correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway.

Phase II trial of cetuximab and conformal radiotherapy only in locally advanced pancreatic cancer with concurrent tissue sampling feasibility study (2014)
Journal Article
Rembielak, A. I., Jain, P., Jackson, A. S., Green, M. M., Santorelli, G. R., Whitfield, G. A., Crellin, A., Garcia-Alonso, A., Radhakrishna, G., Cullen, J., Taylor, M. B., Swindell, R., West, C. M., Valle, J., Saleem, A., & Price, P. M. (2014). Phase II trial of cetuximab and conformal radiotherapy only in locally advanced pancreatic cancer with concurrent tissue sampling feasibility study. Translational Oncology, 7(1), 55-64. https://doi.org/10.1593/tlo.13724

BACKGROUND: Preclinical data have indicated the anti-epidermal growth factor receptor (EGFR) agent cetuximab (Erbitux) as a radiosensitizer in pancreatic cancer, but this has not been specifically addressed in a clinical study. We report the results... Read More about Phase II trial of cetuximab and conformal radiotherapy only in locally advanced pancreatic cancer with concurrent tissue sampling feasibility study.

Tumor survivin is downregulated by the antisense oligonucleotide LY2181308: A proof-of-concept, first-in-human dose study (2010)
Journal Article
Talbot, D. C., Ranson, M., Davies, J., Lahn, M., Callies, S., André, V., Kadam, S., Burgess, M., Slapak, C., Olsen, A. L., McHugh, P. J., De Bono, J. S., Matthews, J., Saleem, A., & Price, P. (2010). Tumor survivin is downregulated by the antisense oligonucleotide LY2181308: A proof-of-concept, first-in-human dose study. Clinical cancer research : an official journal of the American Association for Cancer Research, 16(24), 6150-6158. https://doi.org/10.1158/1078-0432.CCR-10-1932

Purpose: Enhanced tumor cell survival through expression of inhibitors of apoptosis (IAP) is a hallmark of cancer. Survivin, an IAP absent from most normal tissues, is overexpressed in many malignancies and associated with a poorer prognosis. We repo... Read More about Tumor survivin is downregulated by the antisense oligonucleotide LY2181308: A proof-of-concept, first-in-human dose study.

Development and validation of a variance model for dynamic PET: Uses in fitting kinetic data and optimizing the injected activity (2010)
Journal Article
Walker, M. D., Matthews, J. C., Asselin, M. C., Watson, C. C., Saleem, A., Dickinson, C., Charnley, N., Julyan, P. J., Price, P. M., & Jones, T. (2010). Development and validation of a variance model for dynamic PET: Uses in fitting kinetic data and optimizing the injected activity. Physics in Medicine and Biology, 55(22), 6655-6672. https://doi.org/10.1088/0031-9155/55/22/005

The precision of biological parameter estimates derived from dynamic PET data can be limited by the number of acquired coincidence events (prompts and randoms). These numbers are affected by the injected activity (A0). The benefits of optimizing A0 w... Read More about Development and validation of a variance model for dynamic PET: Uses in fitting kinetic data and optimizing the injected activity.

Efficacy and Tolerability of Limited Field Radiotherapy with Concurrent Capecitabine in Locally Advanced Pancreatic Cancer (2010)
Journal Article
Jackson, A. S., Jain, P., Watkins, G. R., Whitfield, G. A., Green, M. M., Valle, J., Taylor, M. B., Dickinson, C., Price, P. M., & Saleem, A. (2010). Efficacy and Tolerability of Limited Field Radiotherapy with Concurrent Capecitabine in Locally Advanced Pancreatic Cancer. Clinical Oncology, 22(7), 570-577. https://doi.org/10.1016/j.clon.2010.06.007

Aims: Patients with locally advanced pancreatic cancer (LAPC) are most commonly managed with chemotherapy or concurrent chemoradiotherapy (CRT), which may or may not include non-involved regional lymph nodes in the clinical target volume. We present... Read More about Efficacy and Tolerability of Limited Field Radiotherapy with Concurrent Capecitabine in Locally Advanced Pancreatic Cancer.

Radiotherapy in the management of unresectable locally advanced pancreatic cancer: A survey of the current UK practice of clinical oncologists (2010)
Journal Article
Saleem, A., Jackson, A., Mukherjee, S., Stones, N., Crosby, T., Tait, D., & Price, P. (2010). Radiotherapy in the management of unresectable locally advanced pancreatic cancer: A survey of the current UK practice of clinical oncologists. Clinical Oncology, 22(4), 257-260. https://doi.org/10.1016/j.clon.2010.02.004

A survey was conducted by the Academic Clinical Oncology and Radiobiology Research Network (ACORRN) to evaluate current radiotherapy practice and to inform future research needs in patients with locally advanced pancreatic cancer. A clear need for a... Read More about Radiotherapy in the management of unresectable locally advanced pancreatic cancer: A survey of the current UK practice of clinical oncologists.

Measurement of cardiac synchrony using Approximate Entropy applied to nuclear medicine scans (2010)
Journal Article
Cullen, J., Saleem, A., Swindell, R., Burt, P., & Moore, C. (2010). Measurement of cardiac synchrony using Approximate Entropy applied to nuclear medicine scans. Biomedical Signal Processing and Control, 5(1), 32-36. https://doi.org/10.1016/j.bspc.2009.07.002

As cancer therapy becomes more effective, allowing patients to live longer, the long-term morbidity of treatment assumes greater significance. Trastuzumab (Herceptin®), a monoclonal antibody that targets the epidermal growth factor, has proven effica... Read More about Measurement of cardiac synchrony using Approximate Entropy applied to nuclear medicine scans.

Optimization of the injected activity in dynamic 3D PET: A generalized approach using patient-specific NECs as demonstrated by a series of 15O-H2O scans (2009)
Journal Article
Walker, M. D., Matthews, J. C., Asselin, M. C., Saleem, A., Dickinson, C., Charnley, N., Julyan, P. J., Price, P. M., & Jones, T. (2009). Optimization of the injected activity in dynamic 3D PET: A generalized approach using patient-specific NECs as demonstrated by a series of 15O-H2O scans. Journal of nuclear medicine, 50(9), 1409-1417. https://doi.org/10.2967/jnumed.109.062679

The magnitude of the injected activity (A0) has a direct impact on the statistical quality of PET images. This study aimed to develop a generalized method for maximizing the statistical quality of dynamic PET images by optimizing A0. Methods: Patient... Read More about Optimization of the injected activity in dynamic 3D PET: A generalized approach using patient-specific NECs as demonstrated by a series of 15O-H2O scans.

Blood flow and vd (water): Both biomarkers required for interpreting the effects of vascular targeting agents on tumor and normal tissue (2009)
Journal Article
Kötz, B., West, C., Saleem, A., Jones, T., & Price, P. (2009). Blood flow and vd (water): Both biomarkers required for interpreting the effects of vascular targeting agents on tumor and normal tissue. Molecular Cancer Therapeutics, 8(2), 303-309. https://doi.org/10.1158/1535-7163.MCT-08-1016

Positron emission tomography studies with oxygen-15-labeled water provide in vivo quantitative tissue perfusion variables - blood flow and fractional volume of distribution of water [Vd (water)]. To investigate the relationship between perfusion vari... Read More about Blood flow and vd (water): Both biomarkers required for interpreting the effects of vascular targeting agents on tumor and normal tissue.