Outputs (198)

A new model for prediction of drug distribution in tumor and normal tissues: Pharmacokinetics of temozolomide in glioma patients (2009)
Journal Article
Rosso, L., Brock, C. S., Gallo, J. M., Saleem, A., Price, P. M., Turkheimer, F. E., & Aboagye, E. O. (2009). A new model for prediction of drug distribution in tumor and normal tissues: Pharmacokinetics of temozolomide in glioma patients. Cancer Research, 69(1), 120-127. https://doi.org/10.1158/0008-5472.CAN-08-2356

Difficulties in direct measurement of drug concentrations in human tissues have hampered the understanding of drug accumulation in tumors and normal tissues. We propose a new system analysis modeling approach to characterize drug distribution in tiss... Read More about A new model for prediction of drug distribution in tumor and normal tissues: Pharmacokinetics of temozolomide in glioma patients.

Early tumor drug pharmacokinetics is influenced by tumor perfusion but not plasma drug exposure (2008)
Journal Article
Saleem, A., & Price, P. M. (2008). Early tumor drug pharmacokinetics is influenced by tumor perfusion but not plasma drug exposure. Clinical cancer research : an official journal of the American Association for Cancer Research, 14(24), 8184-8190. https://doi.org/10.1158/1078-0432.CCR-08-1324

Purpose: Pharmacokinetic parameters derived from plasma sampling are used as a surrogate of tumor pharmacokinetics. However, pharmacokinetics-modulating strategies do not always result in increased therapeutic efficacy. Nonsurrogacy of plasma kinetic... Read More about Early tumor drug pharmacokinetics is influenced by tumor perfusion but not plasma drug exposure.

Suboptimal use of intravenous contrast during radiotherapy planning in the UK (2008)
Journal Article
Kim, S., Russell, W., Price, P., & Saleem, A. (2008). Suboptimal use of intravenous contrast during radiotherapy planning in the UK. British Journal of Radiology, 81(972), 963-969. https://doi.org/10.1259/bjr/24432468

We aimed to evaluate the use of intravenous (IV) contrast during acquisition of radiotherapy planning (RTP) scans and to compare current usage with the Royal College of Radiologists' (RCR) recommendations. Questionnaires were circulated via the Acade... Read More about Suboptimal use of intravenous contrast during radiotherapy planning in the UK.

Maximizing model parameter precision by optimizing dose in 3D [ 150]H20 PET scans (2008)
Presentation / Conference Contribution
Walker, M. D., Matthews, J. C., Asselin, M. C., Watson, C. C., Saleem, A., Charnley, N., Julyan, P. J., Price, P. M., & Jones, T. Maximizing model parameter precision by optimizing dose in 3D [ 150]H20 PET scans

Dynamic PET imaging with [15]H2O allows estimation of tumour perfusion in humans. For small regions of interest these estimates have limited precision due to statistical noise in the images. We have optimized the injected dose in order to improve the... Read More about Maximizing model parameter precision by optimizing dose in 3D [ 150]H20 PET scans.

Plasma pharmacokinetic evaluation of cytotoxic agents radiolabelled with positron emitting radioisotopes (2008)
Journal Article
Saleem, A., Aboagye, E. O., Matthews, J. C., & Price, P. M. (2008). Plasma pharmacokinetic evaluation of cytotoxic agents radiolabelled with positron emitting radioisotopes. Cancer Chemotherapy and Pharmacology, 61(5), 865-873. https://doi.org/10.1007/s00280-007-0552-2

Purpose: This study aimed to evaluate the utility of plasma pharmacokinetic analyses of anti-cancer agents from data obtained during positron emission tomography (PET) oncology studies of radiolabelled anti-cancer agents. Patients and methods: Thirte... Read More about Plasma pharmacokinetic evaluation of cytotoxic agents radiolabelled with positron emitting radioisotopes.

Imaging in cancer (2008)
Journal Article
Rembielak, A., Cullen, J., Saleem, A., & Price, P. (2008). Imaging in cancer. Medicine, 36(1), 5-8. https://doi.org/10.1016/j.mpmed.2007.10.011

Medical imaging techniques are an important element in early detection for many cancers. They are also important for determining the stage and extension of the lesion, assessing tumour response during and after treatment, and locating cancer to aid s... Read More about Imaging in cancer.

Patient-specific noise-equivalent-counts from repeated, dose varying [O-15]H2O PET scans (2007)
Presentation / Conference Contribution
Walker, M. D., Matthews, J. C., Asselin, M. C., Saleem, A., Price, P., & Jones, T. Patient-specific noise-equivalent-counts from repeated, dose varying [O-15]H2O PET scans

Scanning protocols in dynamic PET imaging can be optimised to improve the accuracy and precision of measurements of physiological parameters. For [O-15]H2O scans, one of the major factors that can be controlled is the injected dose, which affects the... Read More about Patient-specific noise-equivalent-counts from repeated, dose varying [O-15]H2O PET scans.

Clinical molecular imaging with positron emission tomography (2006)
Journal Article
Saleem, A., Charnley, N., & Price, P. (2006). Clinical molecular imaging with positron emission tomography. European Journal of Cancer, 42(12), 1720-1727. https://doi.org/10.1016/j.ejca.2006.02.021

Molecular imaging allows for the in vivo evaluation of targeted molecules and biological processes in man. Positron emission tomography (PET) is a highly sensitive and quantitative molecular imaging modality, whose utility in clinical and experimenta... Read More about Clinical molecular imaging with positron emission tomography.

Carbogen and nicotinamide increase blood flow and 5-fluorouracil delivery but not 5-fluorouracil retention in colorectal cancer metastases in patients (2006)
Journal Article
Gupta, N., Saleem, A., Kötz, B., Osman, S., Aboagye, E. O., Phillips, R., Vernon, C., Wasan, H., Jones, T., Hoskin, P. J., & Price, P. M. (2006). Carbogen and nicotinamide increase blood flow and 5-fluorouracil delivery but not 5-fluorouracil retention in colorectal cancer metastases in patients. Clinical cancer research : an official journal of the American Association for Cancer Research, 12(10), 3115-3123. https://doi.org/10.1158/1078-0432.CCR-05-0513

Purpose: To examine whether carbogen and nicotinamide increases 5-fluorouracil (5-FU) delivery to colorectal cancer metastases. Experimental Design: Six patients were scanned using positron emission tomography. Two scans were done to coincide with th... Read More about Carbogen and nicotinamide increase blood flow and 5-fluorouracil delivery but not 5-fluorouracil retention in colorectal cancer metastases in patients.

Potential of PET in oncology and radiotherapy (2005)
Journal Article
Saleem, A. (2005). Potential of PET in oncology and radiotherapy. British Journal of Radiology, 78(SUPPL. 28), 6-16. https://doi.org/10.1259/bjr/44857153

In summary, in addition to its use and value in RTP and research, functional imaging with PET can be utilised in a variety of applications for the research and therapy of cancer. Its value in the elucidation of pathophysiological processes, developme... Read More about Potential of PET in oncology and radiotherapy.

Metabolic activation of temozolomide measured in vivo using positron emission tomography (2003)
Journal Article
Saleem, A., Brown, G. D., Brady, F., Aboagye, E. O., Osman, S., Luthra, S. K., Ranicar, A. S., Brock, C. S., Stevens, M. F., Newlands, E., Jones, T., & Price, P. (2003). Metabolic activation of temozolomide measured in vivo using positron emission tomography. Cancer Research, 63(10), 2409-2415

The purpose of this research was to quantitate and confirm the mechanism of in vivo metabolic activation of temozolomide. The secondary aims were to evaluate the tumor, normal tissue, and plasma pharmacokinetics of temozolomide in vivo, and to determ... Read More about Metabolic activation of temozolomide measured in vivo using positron emission tomography.

Use of positron emission tomography in pharmacokinetic studies to investigate therapeutic advantage in a phase I study of 120-hour intravenous infusion XR5000 (2003)
Journal Article
Propper, D. J., De Bono, J., Saleem, A., Ellard, S., Flanagan, E., Paul, J., Ganesan, T. S., Talbot, D. C., Aboagye, E. O., Price, P., Harris, A. L., & Twelves, C. (2003). Use of positron emission tomography in pharmacokinetic studies to investigate therapeutic advantage in a phase I study of 120-hour intravenous infusion XR5000. Journal of Clinical Oncology, 21(2), 203-210. https://doi.org/10.1200/JCO.2003.02.008

Purpose: XR5000 (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide) is a topoisomerase I and II inhibitor. Because the cytotoxicity of XR5000 increases markedly with prolonged exposure, we performed a phase I study of weekly XR5000 by 120-hour continu... Read More about Use of positron emission tomography in pharmacokinetic studies to investigate therapeutic advantage in a phase I study of 120-hour intravenous infusion XR5000.

Radiolabelled tracers and anticancer drugs for assessment of therapeutic efficacy using PET (2001)
Journal Article
Brady, F., Luthra, S. K., Brown, G. D., Osman, S., Aboagye, E., Saleem, A., & Price, P. M. (2001). Radiolabelled tracers and anticancer drugs for assessment of therapeutic efficacy using PET. Current Pharmaceutical Design, 7(18), 1863-1892. https://doi.org/10.2174/1381612013396907

Positron Emission Tomography (PET) has the potential to improve efficacy of established and novel cancer therapies and to assist more rapid and rational progression of promising novel therapies into the clinic. This is due to PET's unrivalled sensiti... Read More about Radiolabelled tracers and anticancer drugs for assessment of therapeutic efficacy using PET.

Extraction of 5-fluorouracil by tumor and liver: A noninvasive positron emission tomography study of patients with gastrointestinal cancer (2001)
Journal Article
Aboagye, E. O., Saleem, A., Cunningham, V. J., Osman, S., & Price, P. M. (2001). Extraction of 5-fluorouracil by tumor and liver: A noninvasive positron emission tomography study of patients with gastrointestinal cancer. Cancer Research, 61(13), 4937-4941

Tumor and normal tissue pharmacokinetics of 5-Fluorouracil (5-FU) in patients can be determined with positron emission tomography scanning. However, the data obtained are of limited value because of the inability to distinguish catabolites (inactive... Read More about Extraction of 5-fluorouracil by tumor and liver: A noninvasive positron emission tomography study of patients with gastrointestinal cancer.

Pharmacokinetic evaluation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in patients by positron emission tomography (2001)
Journal Article
Saleem, A., Harte, R. J., Matthews, J. C., Osman, S., Brady, F., Luthra, S. K., Brown, G. D., Bleehen, N., Connors, T., Jones, T., Price, P. M., & Aboagye, E. O. (2001). Pharmacokinetic evaluation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in patients by positron emission tomography. Journal of Clinical Oncology, 19(5), 1421-1429. https://doi.org/10.1200/JCO.2001.19.5.1421

Purpose: To evaluate tumor, normal tissue, and plasma pharmacokinetics of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA). The study aimed to determine the pharmacokinetics of carbon-11-labeled DACA ([11C]DACA) and evaluate the effect of phar... Read More about Pharmacokinetic evaluation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in patients by positron emission tomography.

Modulation of fluorouracil tissue pharmacokinetics by eniluracil: In-vivo imaging of drug action (2000)
Journal Article
Saleem, A., Yap, J., Osman, S., Brady, F., Suttle, B., Lucas, S. V., Jones, T., Price, P. M., & Aboagye, E. O. (2000). Modulation of fluorouracil tissue pharmacokinetics by eniluracil: In-vivo imaging of drug action. Lancet, 355(9221), 2125-2131. https://doi.org/10.1016/S0140-6736%2800%2902380-1

Background. Fluorouracil is widely used for chemotherapy of gastrointestinal cancer, but response rates are poor. Eniluracil is being developed as an inactivator of dihydropyrimidine dehydrogenase, the enzyme that brings about first-pass degradation... Read More about Modulation of fluorouracil tissue pharmacokinetics by eniluracil: In-vivo imaging of drug action.

In vivo monitoring of drugs using radiotracer techniques (2000)
Journal Article
Saleem, A., Aboagye, E. O., & Price, P. M. (2000). In vivo monitoring of drugs using radiotracer techniques. Advanced Drug Delivery Reviews, 41(1), 21-39. https://doi.org/10.1016/S0169-409X%2899%2900054-X

There is an increasing realization of the role of non-invasive monitoring of drug pharmacology. In this review, we discuss the role of positron emission tomography in such monitoring of tumour and normal tissue drug pharmacokinetics as well as assess... Read More about In vivo monitoring of drugs using radiotracer techniques.

Developing the future of clinical radiopharmacy: Optimising on-chip gallium-68 radiolabelling for pet imaging (2020)
Presentation / Conference Contribution
Nail, V., Tarn, M. D., He, P., Pamme, N., & Archibald, S. J. Developing the future of clinical radiopharmacy: Optimising on-chip gallium-68 radiolabelling for pet imaging. Presented at MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

© 2020 CBMS-0001 Positron emission tomography (PET) imaging is a growing area with major interest in radiometal labelling and dose-on-demand supply. However, current production methods do not match effectively with these requirements. Microreactor te... Read More about Developing the future of clinical radiopharmacy: Optimising on-chip gallium-68 radiolabelling for pet imaging.