Outputs (198)

Efficient N- and C-functionalisation of cyclam macrocycles utilising bisaminal methodology (2004)
Journal Article
Lewis, E. A., Allan, C. C., Boyle, R. W., & Archibald, S. J. (2004). Efficient N- and C-functionalisation of cyclam macrocycles utilising bisaminal methodology. Tetrahedron letters; the international organ for the rapid publication of preliminary communications in organic chemistry, 45(15), 3059-3062. https://doi.org/10.1016/j.tetlet.2004.02.108

An efficient synthesis of C-functionalised cyclam macrocycles that employs bisaminal intermediates and allows N-substitution to be controlled is reported. © 2004 Elsevier Ltd. All rights reserved.

Molecular Imaging Using Supramolecular Nanotube Constructs (2017)
Journal Article
Archibald, S. J. (2017). Molecular Imaging Using Supramolecular Nanotube Constructs. Chem, 3(4), 527-529. https://doi.org/10.1016/j.chempr.2017.09.017

© 2017 In the September issue of Chem, Pascu and co-workers report their research on the application of supramolecular constructs to the formation of multimodality imaging probes. Basing their work on single-walled carbon nanotubes, they encapsulated... Read More about Molecular Imaging Using Supramolecular Nanotube Constructs.

Discovery of antischistosomal drug leads based on tetraazamacrocyclic derivatives and their metal complexes (2016)
Journal Article
Khan, M. O., Keiser, J., Amoyaw, P. N., Hossain, M. F., Vargas, M., Le, J. G., Simpson, N. C., Roewe, K. D., Freeman, T. N., Hasley, T. R., Maples, R. D., Archibald, S. J., & Hubin, T. J. (2016). Discovery of antischistosomal drug leads based on tetraazamacrocyclic derivatives and their metal complexes. Antimicrobial agents and chemotherapy, 60(9), 5331-5336. https://doi.org/10.1128/AAC.00778-16

Copyright © 2016, American Society for Microbiology. All Rights Reserved. Praziquantel (PZQ) is the only drug available for the treatment of schistosomiasis, and since its large-scale use might be associated with the onset of resistance, new antischi... Read More about Discovery of antischistosomal drug leads based on tetraazamacrocyclic derivatives and their metal complexes.

Synthesis and structural studies of two pyridine-armed reinforced cyclen chelators and their transition metal complexes (2016)
Journal Article
Wilson, K. R., Cannon-Smith, D. J., Burke, B. P., Birdsong, O. C., Archibald, S. J., & Hubin, T. J. (2016). Synthesis and structural studies of two pyridine-armed reinforced cyclen chelators and their transition metal complexes. Polyhedron, 114, 118-127. https://doi.org/10.1016/j.poly.2015.11.014

© 2015 Elsevier Ltd. All rights reserved. Two novel pyridine pendant-armed macrocycles structurally reinforced by an ethyl bridge, either between adjacent nitrogens (for side-bridged) or non-adjacent nitrogens (for cross-bridged), have been synthesiz... Read More about Synthesis and structural studies of two pyridine-armed reinforced cyclen chelators and their transition metal complexes.

Advanced Chelator Design for Metal Complexes in Imaging Applications: Radiopharmaceuticals, Protein Targeting, and Conjugation (2016)
Book Chapter
Burke, B. P., Seemann, J., & Archibald, S. J. (2016). Advanced Chelator Design for Metal Complexes in Imaging Applications: Radiopharmaceuticals, Protein Targeting, and Conjugation. In Advances in Inorganic Chemistry (301-339). https://doi.org/10.1016/bs.adioch.2015.11.002

© 2016 Elsevier Inc. Chelating ligands can be designed to control the interactions of metal complexes with biological systems with specific relevance to molecular imaging techniques. Properties of interest include the stability of the complex under p... Read More about Advanced Chelator Design for Metal Complexes in Imaging Applications: Radiopharmaceuticals, Protein Targeting, and Conjugation.

Simple fabrication of all-glass herringbone devices for the rapid production of liposomes (2016)
Presentation / Conference Contribution
Tarn, M. D., Peyman, S. A., Archibald, S. J., Evans, S. D., & Pamme, N. Simple fabrication of all-glass herringbone devices for the rapid production of liposomes. Presented at 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

We present the fabrication of all-glass microfluidic chips featuring staggered herringbone mixers (SHMs) capable of handling high flow rates for the preparation of liposome capsules in minutes.

Microfluidic radiolabelling of the chelator DOTA with gallium-68 at room temperature for use in PET imaging (2016)
Presentation / Conference Contribution
Bignell, H. A., Tarn, M. D., Burke, B. P., Pamme, N., & Archibald, S. J. Microfluidic radiolabelling of the chelator DOTA with gallium-68 at room temperature for use in PET imaging. Presented at 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

We present, for the first time, the quantitative radiolabelling at room temperature of the 'workhorse' bifunctional chelator, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) with the gallium-68 radiometal for the production of positro... Read More about Microfluidic radiolabelling of the chelator DOTA with gallium-68 at room temperature for use in PET imaging.

Plastic scintillator-based microfluidic devices for radiodetection towards the quality control testing of pet radiotracers (2016)
Presentation / Conference Contribution
Tarn, M. D., Yavuzkanat, N., Esfahani, M. M., Brown, N. J., Pamme, N., Jenkins, D., & Archibald, S. J. Plastic scintillator-based microfluidic devices for radiodetection towards the quality control testing of pet radiotracers. Presented at 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

We present the use of microfluidic devices fabricated from a plastic scintillator, in combination with miniaturised silicon photomultipliers (SiPM), for the detection of positron-emitting [ 18 F]fluoride towards micro-HPLC detection that will form pa... Read More about Plastic scintillator-based microfluidic devices for radiodetection towards the quality control testing of pet radiotracers.

Probing the Limits of Tetraazamacrocycle-Glyoxal Condensates as Bidentate Ligands for Cu2+ (2015)
Journal Article
Won, P. D., Funwie, N. L., Birdsong, O. C., Obali, A. Y., Burke, B. P., McRobbie, G., Greenman, P., Prior, T. J., Archibald, S. J., & Hubin, T. J. (2015). Probing the Limits of Tetraazamacrocycle-Glyoxal Condensates as Bidentate Ligands for Cu2+. European Journal of Inorganic Chemistry, 2015(28), 4678-4688. https://doi.org/10.1002/ejic.201500683

Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Tetracyclic bisaminals formed by condensation of tetraazamacrocycles and glyoxal have rarely been utilized as ligands for transition metal ions. Five novel Cu 2+ complexes are presented... Read More about Probing the Limits of Tetraazamacrocycle-Glyoxal Condensates as Bidentate Ligands for Cu2+.

Adoptive cell transfer after chemotherapy enhances survival in patients with resectable HNSCC (2015)
Journal Article
Jiang, P., Zhang, Y., J Archibald, S., & Wang, H. (2015). Adoptive cell transfer after chemotherapy enhances survival in patients with resectable HNSCC. International immunopharmacology, 28(1), 208-214. https://doi.org/10.1016/j.intimp.2015.05.042

© 2015 Elsevier B.V. All rights reserved. Objectives The aims of this study were to evaluate the therapeutic efficacy and to determine the immune factors for treatment success in patients with head and neck squamous cell carcinoma (HNSCC) treated wit... Read More about Adoptive cell transfer after chemotherapy enhances survival in patients with resectable HNSCC.

Phosphonium-boronate amino acid derivatives as fluoride pincers for ¹⁸F-labelling (2015)
Journal Article
Bernard, J., Clemente, G., Burke, B. P., Eymin, M. J., Archibald, S. J., Malacea-Kabbara, R., & Jugé, S. (2015). Phosphonium-boronate amino acid derivatives as fluoride pincers for 18F-labelling. Phosphorus, sulfur, and silicon and the related elements, 190(5-6), 957-958. https://doi.org/10.1080/10426507.2014.979991

Copyright © 2015 Taylor & Francis Group, LLC. The synthesis of phosphonium-boronate amino acid derivatives was achieved by quaternization of o-boronatophenylphosphine with iodo-amino acid derivatives. Preliminary radiolabelling studies demonstrate... Read More about Phosphonium-boronate amino acid derivatives as fluoride pincers for ¹⁸F-labelling.

o-Boronato- and o-Trifluoroborato - Phosphonium Salts Supported by L-α-Amino Acid Side Chain (2015)
Journal Article
Bernard, J., Malacea-Kabbara, R., Clemente, G. S., Burke, B. P., Eymin, M. J., Archibald, S. J., & Jugé, S. (2015). o-Boronato- and o-Trifluoroborato - Phosphonium Salts Supported by L-α-Amino Acid Side Chain. Journal of Organic Chemistry, 80(9), 4289-4298. https://doi.org/10.1021/acs.joc.5b00246

© 2015 American Chemical Society. (Figure Presented) The synthesis of o-boronato- and o-trifluoroborato-phosphonium salts supported by the l-amino acid side chain is described. The synthesis of these new class of amino acid derivatives was achieved b... Read More about o-Boronato- and o-Trifluoroborato - Phosphonium Salts Supported by L-α-Amino Acid Side Chain.

Dalton discussion 15 - Metal ions in medical imaging: Optical, radiopharmaceutical and MRI contrast, 8th-10th September 2014, York (2015)
Journal Article
Archibald, S. J., & Tripier, R. (2015). Dalton discussion 15 - Metal ions in medical imaging: Optical, radiopharmaceutical and MRI contrast, 8th-10th September 2014, York. Dalton Transactions : an international journal of inorganic chemistry, 44(11), 4789-4790. https://doi.org/10.1039/c5dt90036k

Boron-¹⁸F containing positron emission tomography radiotracers: Advances and opportunities (2015)
Journal Article
Burke, B. P., Clemente, G. S., & Archibald, S. J. (2015). Boron-18F containing positron emission tomography radiotracers: Advances and opportunities. Contrast media & molecular imaging, 10(2), 96-110. https://doi.org/10.1002/cmmi.1615

© 2014 John Wiley & Sons, Ltd. Standard [ < sup > 18 < /sup > F]fluorination methods to form carbon-fluorine bonds can have some limitations such as low yield and the requirement for harsh reaction conditions. Inorganic approaches include the forma... Read More about Boron-¹⁸F containing positron emission tomography radiotracers: Advances and opportunities.

On-chip detection of radioactivity via silicon-based sensors for the quality control testing of radiopharmaceuticals (2015)
Presentation / Conference Contribution
Taggart, M. P., Tarn, M. D., Esfahani, M. M., Archibald, S. J., Deakin, T., Pamme, N., & Thompson, L. F. On-chip detection of radioactivity via silicon-based sensors for the quality control testing of radiopharmaceuticals. Presented at MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

© 15CBMS-0001. We present the use of highly sensitive, small footprint, low cost silicon photomultipliers (SiPM) for radioactivity detection in microfluidic channels, with a view to their integration into miniaturised quality control (QC) platforms f... Read More about On-chip detection of radioactivity via silicon-based sensors for the quality control testing of radiopharmaceuticals.

Final step gallium-68 radiolabelling of silica-coated iron oxide nanorods as potential PET/MR multimodal imaging agents (2014)
Journal Article
Burke, B. P., Baghdadi, N., Clemente, G. S., Camus, N., Guillou, A., Kownacka, A. E., Domarkas, J., Halime, Z., Tripier, R., & Archibald, S. J. (2014). Final step gallium-68 radiolabelling of silica-coated iron oxide nanorods as potential PET/MR multimodal imaging agents. Faraday Discussions, 175, 59-71. https://doi.org/10.1039/c4fd00137k

© The Royal Society of Chemistry. The investigation of iron oxide-based positron emission tomography/magnetic resonance (PET/MR) multimodal imaging agents is an expanding field in which a variety of nanoparticle sizes, shapes, surface coatings and ra... Read More about Final step gallium-68 radiolabelling of silica-coated iron oxide nanorods as potential PET/MR multimodal imaging agents.

A benzimidazole functionalised DO3A chelator showing pH switchable coordination modes with lanthanide ions (2014)
Journal Article
Fisher, C. M., Fuller, E., Burke, B. P., Mogilireddy, V., Pope, S. J., Sparke, A. E., Déchamps-Olivier, I., Cadiou, C., Chuburu, F., Faulkner, S., & Archibald, S. J. (2014). A benzimidazole functionalised DO3A chelator showing pH switchable coordination modes with lanthanide ions. Dalton Transactions : an international journal of inorganic chemistry, 43(25), 9567-9578. https://doi.org/10.1039/c4dt00519h

The synthesis of a new macrocyclic chelator incorporating a benzimidazole heterocycle is reported. Lanthanide complexes with macrocyclic chelators based on 1,4,7,10-tetra(carboxymethyl)-1,4,7,10-tetraazacyclododecane (DOTA) and 1,4,7-tris(carboxymeth... Read More about A benzimidazole functionalised DO3A chelator showing pH switchable coordination modes with lanthanide ions.

Synthesis and antimalarial activity of metal complexes of cross-bridged tetraazamacrocyclic ligands (2014)
Journal Article
Hubin, T. J., Amoyaw, P. N., Roewe, K. D., Simpson, N. C., Maples, R. D., Carder Freeman, T. N., Cain, A. N., Le, J. G., Archibald, S. J., Khan, S. I., Tekwani, B. L., & Khan, M. O. (2014). Synthesis and antimalarial activity of metal complexes of cross-bridged tetraazamacrocyclic ligands. Bioorganic & medicinal chemistry, 22(13), 3239-3244. https://doi.org/10.1016/j.bmc.2014.05.003

Using transition metals such as manganese(II), iron(II), cobalt(II), nickel(II), copper(II), and zinc(II), several new metal complexes of cross-bridged tetraazamacrocyclic chelators namely, cyclen- and cyclam-analogs with benzyl groups, were synthesi... Read More about Synthesis and antimalarial activity of metal complexes of cross-bridged tetraazamacrocyclic ligands.

Recent advances in chelator design and labelling methodology for 68Ga radiopharmaceuticals (2014)
Journal Article
Burke, B. P., Clemente, G. S., & Archibald, S. J. (2014). Recent advances in chelator design and labelling methodology for 68Ga radiopharmaceuticals. Journal of Labelled Compounds and Radiopharmaceuticals, 57(4), 239-243. https://doi.org/10.1002/jlcr.3146

Gallium-68 has the potential to become the technetium-99m of positron emission tomography with ideal decay characteristics and a long-lived parent isotope for generator production. The work in the area of 68 Ga is focused on two key areas: (1) synth... Read More about Recent advances in chelator design and labelling methodology for 68Ga radiopharmaceuticals.

On-chip absorbance spectroscopy for the determination of optical clarity and PH for the quality control testing of [¹⁸F]FDG radiotracer (2014)
Presentation / Conference Contribution
Tarn, M. D., Isu, A., Archibald, S. J., & Pamme, N. On-chip absorbance spectroscopy for the determination of optical clarity and PH for the quality control testing of [18F]FDG radiotracer. Presented at 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

© 14CBMS. We present on-chip absorbance-based determination of pH and optical clarity for quality control (QC) testing of 2-[ < sup > 18 < /sup > F]fluoro-2-deoxy-D-glucose ([ < sup > 18 < /sup > F]FDG), a positron emission tomography (PET) radiotrac... Read More about On-chip absorbance spectroscopy for the determination of optical clarity and PH for the quality control testing of [¹⁸F]FDG radiotracer.