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Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon? (2021)
Journal Article
Atkinson, L., Martin, F., & Sturmey, R. G. (2021). Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?. Human Reproduction, 36(7), 1737-1750. https://doi.org/10.1093/humrep/deab106

The prospect of ovarian rejuvenation offers the tantalising prospect of treating age-related declines in fertility or in pathological conditions such as premature ovarian failure. The concept of ovarian rejuvenation was invigorated by the indication... Read More about Intraovarian injection of platelet-rich plasma in assisted reproduction: too much too soon?.

Ovarian Cancer in the Sudan - Identifying the Social and Clinical Factors that Prevent an Early Diagnosis (2021)
Journal Article
Mohamed, E., Bature, F., Ali, I., Abdelaziz, F., Alsayed, S., Mukhtar, M., …Guinn, B. (2021). Ovarian Cancer in the Sudan - Identifying the Social and Clinical Factors that Prevent an Early Diagnosis. Austin Journal of Obstetrics and Gynecology, 8(5), Article 1181. https://doi.org/10.26420/austiniobstetgynecol.2021.1181

Ovarian cancer, because it often presents with vague symptoms, is a difficult disease to diagnose at the early stages, especially in developing countries. In Sudan, diagnosis is further complicated by additional factors and challenges. First, as in a... Read More about Ovarian Cancer in the Sudan - Identifying the Social and Clinical Factors that Prevent an Early Diagnosis.

Biofilm-Infected Human Clusteroid Three-Dimensional Coculture Platform to Replace Animal Models in Testing Antimicrobial Nanotechnologies (2021)
Journal Article
Wang, A., Weldrick, P., Madden, L. A., & Paunov, V. N. (2021). Biofilm-Infected Human Clusteroid Three-Dimensional Coculture Platform to Replace Animal Models in Testing Antimicrobial Nanotechnologies. ACS Applied Materials & Interfaces, 13(19), 22182-22194. https://doi.org/10.1021/acsami.1c02679

Microbial biofilms are a major concern in wound care, implant devices, and organ infections. Biofilms allow higher tolerance to antimicrobial drugs, can impair wound healing, and potentially lead to sepsis. There has been a recent focus on developing... Read More about Biofilm-Infected Human Clusteroid Three-Dimensional Coculture Platform to Replace Animal Models in Testing Antimicrobial Nanotechnologies.

Current and emerging investigational venetoclax-based therapies in chronic lymphocytic leukemia (2021)
Journal Article
Molica, S., Allsup, D., Gianfelici, V., Levato, L., Aiello, V., Bailey, J., & Polliack, A. (in press). Current and emerging investigational venetoclax-based therapies in chronic lymphocytic leukemia. Expert Opinion on Investigational Drugs, https://doi.org/10.1080/13543784.2021.1924669

Introduction: Venetoclax has emerged as a breakthrough treatment which has revolutionized the therapeutic paradigm of chronic lymphocytic leukemia (CLL). This is primarily attributed to the efficacy of venetoclax as a time-limited, chemo-free, therap... Read More about Current and emerging investigational venetoclax-based therapies in chronic lymphocytic leukemia.

Effect of treatment planning system parameters on beam modulation complexity for treatment plans with single-layer multi-leaf collimator and dual-layer stacked multi-leaf collimator (2021)
Journal Article
Quintero, P., Cheng, Y., Benoit, D., Moore, C., & Beavis, A. (2021). Effect of treatment planning system parameters on beam modulation complexity for treatment plans with single-layer multi-leaf collimator and dual-layer stacked multi-leaf collimator. British Journal of Radiology, 94(1122), Article 20201011. https://doi.org/10.1259/bjr.20201011

OBJECTIVE: High levels of beam modulation complexity (MC) and monitor units (MU) can compromise the plan deliverability of intensity-modulated radiotherapy treatments. Our study evaluates the effect of three treatment planning system (TPS) parameters... Read More about Effect of treatment planning system parameters on beam modulation complexity for treatment plans with single-layer multi-leaf collimator and dual-layer stacked multi-leaf collimator.

Radiolabelling an 18F biologic via facile IEDDA “click” chemistry on the GE FASTLab™ platform (2021)
Journal Article
Allott, L., Amgheib, A., Barnes, C., Braga, M., Brickute, D., Wang, N., …Aboagye, E. O. (in press). Radiolabelling an 18F biologic via facile IEDDA “click” chemistry on the GE FASTLab™ platform. Reaction Chemistry and Engineering, https://doi.org/10.1039/d1re00117e

The use of biologics in positron emission tomography (PET) imaging is an important area of radiopharmaceutical development and new automated methods are required to facilitate their production. We report an automated radiosynthesis method to produce... Read More about Radiolabelling an 18F biologic via facile IEDDA “click” chemistry on the GE FASTLab™ platform.

Release of redox enzymes and micro-RNAs in extracellular vesicles, during infection and inflammation (2021)
Journal Article
Caserta, S., & Ghezzi, P. (2021). Release of redox enzymes and micro-RNAs in extracellular vesicles, during infection and inflammation. Free radical biology & medicine, 169, 248-257. https://doi.org/10.1016/j.freeradbiomed.2021.04.010

Many studies reported that redox enzymes, particularly thioredoxin and peroxiredoxin, can be released by cells and act as soluble mediators in immunity. Recently, it became clear that peroxiredoxins can be secreted via the exosome-release route, yet... Read More about Release of redox enzymes and micro-RNAs in extracellular vesicles, during infection and inflammation.

The effects of chlorination, thickness, and moisture on glove donning efficiency (2021)
Journal Article
Preece, D., Hong Ng, T., Tong, H. K., Lewis, R., & Carré, M. J. (2021). The effects of chlorination, thickness, and moisture on glove donning efficiency. Ergonomics, 64(9), 1205-1216. https://doi.org/10.1080/00140139.2021.1907452

Changing gloves more frequently is encouraged, more now than ever given the COVID-19 pandemic. When the donning process has moisture introduced, however, complications can arise, which consumes vital time. Most commonly, gloves undergo a chlorination... Read More about The effects of chlorination, thickness, and moisture on glove donning efficiency.

Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells (2021)
Journal Article
Kirkham, F., Pera, A., Simanek, A. M., Bano, A., Morrow, G., Reus, B., …Kern, F. (in press). Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells. Theranostics, 11(12), 5728-5741. https://doi.org/10.7150/thno.58356

Human Cytomegalovirus (CMV) infection is associated with atherosclerosis, higher cardiovascular disease (CVD) risk, and an increase in memory T-cells (Tmem). T-cells have also been implicated in CVD, independently of CMV infection. To better understa... Read More about Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells.