Outputs (933)

Fixed Duration Ibrutinib‐Venetoclax, a Redefinition of the CLL Treatment Landscape (2025)
Journal Article
Molica, S., & Allsup, D. (2025). Fixed Duration Ibrutinib‐Venetoclax, a Redefinition of the CLL Treatment Landscape. Hematological Oncology, 43(3), Article e70088. https://doi.org/10.1002/hon.70088

The fixed-duration combination of ibrutinib and venetoclax (IV) has emerged as a highly effective therapeutic strategy for treating chronic lymphocytic leukemia (CLL), marking a significant shift in the treatment paradigm for this disease. Preclinica... Read More about Fixed Duration Ibrutinib‐Venetoclax, a Redefinition of the CLL Treatment Landscape.

Adult B-Cell Acute Lymphoblastic Leukaemia Antigens and Enriched Pathways Identify New Targets for Therapy (2025)
Journal Article
Mohamed, E., Goodman, S., Cooksey, L., Fletcher, D. M., Dean, O., Boncheva, V. B., Mills, K. I., Orchard, K. H., & Guinn, B.-A. (2025). Adult B-Cell Acute Lymphoblastic Leukaemia Antigens and Enriched Pathways Identify New Targets for Therapy. Onco, 5(2), Article 19. https://doi.org/10.3390/onco5020019

Background: Adult B-cell acute lymphoblastic leukaemia (aB-ALL) is charac-terised by abnormal differentiation and proliferation of lymphoid progenitors. Despite a significant improvement in relapse-free and overall survival for children with BALL , a... Read More about Adult B-Cell Acute Lymphoblastic Leukaemia Antigens and Enriched Pathways Identify New Targets for Therapy.

Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System (2025)
Thesis
Barry, A. (2025). Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5133792

Glioblastoma (GBM) is the most common primary malignancy in the central nervous system and the most devastating, with a median survival of 18 months from diagnosis. The development of models to research and understand GBM tumourigenesis and progressi... Read More about Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System.

The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing (2025)
Thesis
Rodriguez-Barucg, Q. (2025). The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5126336

This thesis investigates the role of environmentally relevant concentrations of fluoxetine, a commonly prescribed selective serotonin reuptake inhibitor (SSRI), in wound healing. While SSRIs are effective in treating psychiatric conditions, their inc... Read More about The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing.

O-GlcNAcylation and Phosphorylation Crosstalk in Vascular Smooth Muscle Cells: Cellular and Therapeutic Significance in Cardiac and Vascular Pathologies (2025)
Journal Article
Bolanle, I. O., & Palmer, T. M. (2025). O-GlcNAcylation and Phosphorylation Crosstalk in Vascular Smooth Muscle Cells: Cellular and Therapeutic Significance in Cardiac and Vascular Pathologies. International Journal of Molecular Sciences, 26(7), Article 3303. https://doi.org/10.3390/ijms26073303

More than 400 different types of post-translational modifications (PTMs), including O-GlcNAcylation and phosphorylation, combine to co-ordinate almost all aspects of protein function. Often, these PTMs overlap and the specific relationship between O-... Read More about O-GlcNAcylation and Phosphorylation Crosstalk in Vascular Smooth Muscle Cells: Cellular and Therapeutic Significance in Cardiac and Vascular Pathologies.

Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events (2025)
Thesis
Papachristofi, V. (2025). Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/5038856

The modern environment in which we live is replete with chemicals that have accumulated to levels that have been proposed to impact various aspects of physiology. The impact of a selection of these environmental contaminants on the physiology of earl... Read More about Investigating the impact of environmental contaminants on periconceptual environment and early reproductive events.

The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue (2025)
Thesis
Golebiewski, P. (2025). The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5087881

Thyroid cancer (TC) is the most common endocrine malignancy globally. While surgery and radioactive iodine (RAI) therapy generally yield favourable outcomes, prognosis worsens in RAI-refractory or resistant cases, highlighting the need for alternativ... Read More about The Creation of 3D Thyroid Models to Investigate the Effects of Sorafenib on Thyroid Tumour Tissue.

Tissue factor signalling modifies the expression and regulation of G1/S checkpoint regulators: Implications during injury and prolonged inflammation (2024)
Journal Article
Featherby, S., Faulkner, E., & Ettelaie, C. (2025). Tissue factor signalling modifies the expression and regulation of G1/S checkpoint regulators: Implications during injury and prolonged inflammation. Molecular Medicine Reports, 31(2), Article 39. https://doi.org/10.3892/mmr.2024.13404

Tissue factor (TF) possesses additional physiological functions beyond initiating the coagulation cascade. Cellular signals initiated by cellular TF or on contact with TF-containing microvesicles, contribute to wound healing through regulating a numb... Read More about Tissue factor signalling modifies the expression and regulation of G1/S checkpoint regulators: Implications during injury and prolonged inflammation.

Are There Non-Invasive Biomarker(s) That Would Facilitate the Detection of Ovarian Torsion? A Systematic Review and Meta-Analysis (2024)
Journal Article
Naylor, M., Doherty, G., Draper, H., Fletcher, D. M., Rigby, A., Adedipe, T., & Guinn, B. A. (2024). Are There Non-Invasive Biomarker(s) That Would Facilitate the Detection of Ovarian Torsion? A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 25(21), Article 11664. https://doi.org/10.3390/ijms252111664

Ovarian torsion (OT) is a rare gynaecological emergency that requires a prompt diagnosis for optimal patient management. To determine whether there were any biomarkers suitable for the non-invasive detection of OT, two independent reviewers performed... Read More about Are There Non-Invasive Biomarker(s) That Would Facilitate the Detection of Ovarian Torsion? A Systematic Review and Meta-Analysis.

Recent Advancements in the Use of Olive Products for Biotechnological Processes (2024)
Book Chapter
Efthimiou, G. (2024). Recent Advancements in the Use of Olive Products for Biotechnological Processes. In V. Lagouri (Ed.), Olives and Olive Related Products - Innovations in Production and Processing (1-8). IntechOpen. https://doi.org/10.5772/intechopen.1007424

This chapter discusses the most recent applications of olive-derived materials in biotechnology, agriculture and food technology. Although the high-quality olive oil is usually destined for human consumption, lower oil grades or waste materials from... Read More about Recent Advancements in the Use of Olive Products for Biotechnological Processes.