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Outputs (1113)

Environmental fluoxetine promotes skin cell proliferation and wound healing (2024)
Journal Article
Rodriguez-Barucg, Q., Garcia, A. A., Garcia-Merino, B., Akinmola, T., Okotie-Eboh, T., Francis, T., Bringas, E., Ortiz, I., Wade, M., Dowle, A., Joyce, D. A., Hardman, M. J., Wilkinson, H. N., & Beltran-Alvarez, P. (2024). Environmental fluoxetine promotes skin cell proliferation and wound healing. Environmental pollution, 362, Article 124952. https://doi.org/10.1016/j.envpol.2024.124952

This study investigates the effects of environmentally-relevant concentrations of fluoxetine (FLX, commercial name: Prozac) on wound healing. Pollution of water systems with pharmaceutical and personal care products, including antidepressants such as... Read More about Environmental fluoxetine promotes skin cell proliferation and wound healing.

An in vitro multi-organ microphysiological system (MPS) to investigate the gut-to-brain translocation of neurotoxins (2024)
Journal Article
Jones, E. J., Skinner, B. M., Parker, A., Baldwin, L. R., Greenman, J., Carding, S. R., & Funnell, S. G. (2024). An in vitro multi-organ microphysiological system (MPS) to investigate the gut-to-brain translocation of neurotoxins. Biomicrofluidics, 18(5), Article 054105. https://doi.org/10.1063/5.0200459

The death of dopamine-producing neurons in the substantia nigra in the base of the brain is a defining pathological feature in the development of Parkinson's disease (PD). PD is, however, a multi-systemic disease, also affecting the peripheral nervou... Read More about An in vitro multi-organ microphysiological system (MPS) to investigate the gut-to-brain translocation of neurotoxins.

Brain and Lung Biomarker Responses to Hyperoxic Hypobaric Decompression (2024)
Journal Article
Connolly, D., Madden, L. A., Edwards, V., & Lee, V. (2024). Brain and Lung Biomarker Responses to Hyperoxic Hypobaric Decompression. Aerospace Medicine and Human Performance, 95(9), 667-674. https://doi.org/10.3357/AMHP.6391.2024

INTRODUCTION: Biomarker responses to intensive decompression indicate systemic proinflammatory responses and possible neurological stress. To further investigate responses, 12 additional brain and lung biomarkers were assayed. METHODS: A total of 15... Read More about Brain and Lung Biomarker Responses to Hyperoxic Hypobaric Decompression.

Effects of resistance training on quality of life, fatigue, physical function, and muscular strength during chemotherapy treatment: a systematic review and meta-analysis (2024)
Journal Article
Metcalfe, J., Orange, S., Madden, L. A., Marshall, P., & Vince, R. V. (2024). Effects of resistance training on quality of life, fatigue, physical function, and muscular strength during chemotherapy treatment: a systematic review and meta-analysis. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 32(9), Article 593. https://doi.org/10.1007/s00520-024-08766-y

Purpose: To systematically review and meta-analyse the efficacy of resistance training on quality of life (QOL), fatigue, physical function, and muscular strength in people diagnosed with cancer undergoing chemotherapy. Methods: Electronic databases... Read More about Effects of resistance training on quality of life, fatigue, physical function, and muscular strength during chemotherapy treatment: a systematic review and meta-analysis.

Unique Coexistence of Two Resistive Switching Modes in a Memristor Device Enables Multifunctional Neuromorphic Computing Properties (2024)
Journal Article
Jaafar, A. H., Al Habsi, S. K. S., Braben, T., Venables, C., Francesconi, M. G., Stasiuk, G. J., & Kemp, N. T. (2024). Unique Coexistence of Two Resistive Switching Modes in a Memristor Device Enables Multifunctional Neuromorphic Computing Properties. ACS Applied Materials & Interfaces, 16(33), 43816–43826. https://doi.org/10.1021/acsami.4c07820

We report on hybrid memristor devices consisting of germanium dioxide nanoparticles (GeO2 NP) embedded within a poly(methyl methacrylate) (PMMA) thin film. Besides exhibiting forming-free resistive switching and an uncommon “ON” state in pristine con... Read More about Unique Coexistence of Two Resistive Switching Modes in a Memristor Device Enables Multifunctional Neuromorphic Computing Properties.

Enhanced anticancer effect of lysozyme-functionalized metformin-loaded shellac nanoparticles on a 3D cell model: role of the nanoparticle and payload concentrations (2024)
Journal Article
Wang, A., Madden, L. A., & Paunov, V. N. (online). Enhanced anticancer effect of lysozyme-functionalized metformin-loaded shellac nanoparticles on a 3D cell model: role of the nanoparticle and payload concentrations. Biomaterials science / Royal Society of Chemistry, https://doi.org/10.1039/d4bm00692e

Here we used a 3D human hepatic tumour cell culture model to assess the in vitro efficacy of “active” metformin-loaded nanoparticles (NPs) as anticancer therapeutics. The metformin nanocarrier design was repurposed from previous studies targeting bac... Read More about Enhanced anticancer effect of lysozyme-functionalized metformin-loaded shellac nanoparticles on a 3D cell model: role of the nanoparticle and payload concentrations.

Network meta-analysis of upfront fixed-duration therapies in chronic lymphocytic leukemia (2024)
Journal Article
Molica, S., Allsup, D., & Giannarelli, D. (online). Network meta-analysis of upfront fixed-duration therapies in chronic lymphocytic leukemia. American Journal of Hematology, https://doi.org/10.1002/ajh.27437

The emergence of Bruton's tyrosine kinase (BTK) inhibitors marked a significant advancement in chronic lymphocytic leukemia (CLL) management, especially for high-risk patients. 1 Ibrutinib, the pioneering BTK inhibitor, has undergone extensive study.... Read More about Network meta-analysis of upfront fixed-duration therapies in chronic lymphocytic leukemia.

An investigation into the TRPV1-CGRP signalling pathway in vessel development (2024)
Thesis
Bates, A. An investigation into the TRPV1-CGRP signalling pathway in vessel development. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4865918

TRPV1 is a non-selective cation channel which is activated through various different factors including, but not limited to, raised temperature and acidic pH. It has been linked in the past to endothelial cell proliferation in acidic conditions, but a... Read More about An investigation into the TRPV1-CGRP signalling pathway in vessel development.

Wound Healing Promotion via Release of Therapeutic Metallic Ions from Phosphate Glass Fibers: An In Vitro and Ex Vivo Study (2024)
Journal Article
Hoxha, A., Nikolaou, A., Wilkinson, H. N., Hardman, M. J., Gutierrez-Merino, J., Felipe-Sotelo, M., & Carta, D. (2024). Wound Healing Promotion via Release of Therapeutic Metallic Ions from Phosphate Glass Fibers: An In Vitro and Ex Vivo Study. ACS Applied Materials & Interfaces, 16(29), 37669-37682. https://doi.org/10.1021/acsami.4c07035

Biomaterials capable of promoting wound healing and preventing infections remain in great demand to address the global unmet need for the treatment of chronic wounds. Phosphate-based glasses (PG) have shown potential as bioresorbable materials capabl... Read More about Wound Healing Promotion via Release of Therapeutic Metallic Ions from Phosphate Glass Fibers: An In Vitro and Ex Vivo Study.