Outputs (1127)

The immune receptor FcRg-chain mediates CD36-induced platelet activation and thrombosis by oxidised low-density lipoproteins (2025)
Journal Article
Wraith, K. S., Khalil, J. S., Aburima, A., Tyng Cheah, L., Hindle, M. S., Berger, M., Uddin, R., Ayub, H., McKay, M., Xu, R.-G., Ariëns, R. A. S., Kearney, M. T., Tomlinson, M. G., & Naseem, K. M. (online). The immune receptor FcRg-chain mediates CD36-induced platelet activation and thrombosis by oxidised low-density lipoproteins. Blood Advances, https://doi.org/10.1182/bloodadvances.2024015652

The scavenger receptor CD36 links atherogenic dyslipidaemia to platelet hyperactivity and accelerated thrombosis through the binding of oxidised low-density lipoproteins (oxLDL). The signalling mechanism(s) that facilitates CD36 translation of oxidat... Read More about The immune receptor FcRg-chain mediates CD36-induced platelet activation and thrombosis by oxidised low-density lipoproteins.

Technical Note: Parameters of Bloodstain Pattern Spatial Reconstruction in Manual vs. Computer-Aided Data Acquisition (2025)
Journal Article
Kowalske, Z., Snively, D. T., Oleiwi, A., & Williams, G. (2025). Technical Note: Parameters of Bloodstain Pattern Spatial Reconstruction in Manual vs. Computer-Aided Data Acquisition. Forensic Science International: Reports, 11, Article 100418. https://doi.org/10.1016/j.fsir.2025.100418

This study compares the accuracy and precision of manual and computer-aided methods in bloodstain pattern analysis using equine blood under controlled conditions. Manual measurements by experienced analysts were compared to those obtained with FARO Z... Read More about Technical Note: Parameters of Bloodstain Pattern Spatial Reconstruction in Manual vs. Computer-Aided Data Acquisition.

Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery (2025)
Journal Article
Lathan, R., Daysley, H., Ravindhran, B., Lim, A., Cutteridge, J., Sidapra, M., Long, J., Hitchman, L., Beltran-Alvarez, P., Carradice, D., Smith, G., & Chetter, I. (2025). Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery. BJS Open, 9(3), Article zraf015. https://doi.org/10.1093/bjsopen/zraf015

BACKGROUND: There is sparse evidence of the relationship between environmental and financial costs of surgical-site infection. Identifying areas of high-cost burden would enable key targets for clinical interventions to aid in achieving the UK nation... Read More about Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery.

LAMPrey: a standardised method for analysing quantitative LAMP (qLAMP) and qPCR reactions using the inflection cycle threshold iCt (2025)
Preprint / Working Paper
Bates, A., Li, J., Rivero, F., & Wollenberg Valero, K. C. (2025). LAMPrey: a standardised method for analysing quantitative LAMP (qLAMP) and qPCR reactions using the inflection cycle threshold iCt

Quantitative Loop-mediated isothermal amplification (qLAMP) is a relatively new method that has gained popularity in recent years, particularly in disease identification, including during the recent SARS-CoV-2 pandemic. Unlike conventional quantitati... Read More about LAMPrey: a standardised method for analysing quantitative LAMP (qLAMP) and qPCR reactions using the inflection cycle threshold iCt.

Fixed Duration Ibrutinib-Venetoclax, a Redefinition of the CLL Treatment Landscape (2025)
Journal Article
Molica, S., & Allsup, D. (2025). Fixed Duration Ibrutinib-Venetoclax, a Redefinition of the CLL Treatment Landscape. Hematological Oncology, 43(3), Article e70088. https://doi.org/10.1002/hon.70088

The fixed-duration combination of ibrutinib and venetoclax (IV) has emerged as a highly effective therapeutic strategy for treating chronic lymphocytic leukemia (CLL), marking a significant shift in the treatment paradigm for this disease. Preclinica... Read More about Fixed Duration Ibrutinib-Venetoclax, a Redefinition of the CLL Treatment Landscape.

Social context prevents heat hormetic effects against mutagens during fish development (2025)
Journal Article
Feugere, L., Silva De Freitas, C., Bates, A., Storey, K. B., Beltran-Alvarez, P., & Wollenberg Valero, K. C. (2025). Social context prevents heat hormetic effects against mutagens during fish development. FEBS Letters, https://doi.org/10.1002/1873-3468.70047

Since stress can be transmitted to congeners via social metabolites, it is paramount to understand how the social context of abiotic stress influences aquatic organisms' responses to global changes. Here, we integrated the transcriptomic and phenotyp... Read More about Social context prevents heat hormetic effects against mutagens during fish development.

Adult B-Cell Acute Lymphoblastic Leukaemia Antigens and Enriched Pathways Identify New Targets for Therapy (2025)
Journal Article
Mohamed, E., Goodman, S., Cooksey, L., Fletcher, D. M., Dean, O., Boncheva, V. B., Mills, K. I., Orchard, K. H., & Guinn, B.-A. (2025). Adult B-Cell Acute Lymphoblastic Leukaemia Antigens and Enriched Pathways Identify New Targets for Therapy. Onco, 5(2), Article 19. https://doi.org/10.3390/onco5020019

Background: Adult B-cell acute lymphoblastic leukaemia (aB-ALL) is charac-terised by abnormal differentiation and proliferation of lymphoid progenitors. Despite a significant improvement in relapse-free and overall survival for children with BALL , a... Read More about Adult B-Cell Acute Lymphoblastic Leukaemia Antigens and Enriched Pathways Identify New Targets for Therapy.

Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System (2025)
Thesis
Barry, A. (2025). Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5133792

Glioblastoma (GBM) is the most common primary malignancy in the central nervous system and the most devastating, with a median survival of 18 months from diagnosis. The development of models to research and understand GBM tumourigenesis and progressi... Read More about Exploring the use of Arginine Methylation Inhibitors Against Brain Tumours in an ex vivo Perfusion System.

The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing (2025)
Thesis
Rodriguez-Barucg, Q. (2025). The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/5126336

This thesis investigates the role of environmentally relevant concentrations of fluoxetine, a commonly prescribed selective serotonin reuptake inhibitor (SSRI), in wound healing. While SSRIs are effective in treating psychiatric conditions, their inc... Read More about The Role of Environmentally Relevant Concentrations of SSRIs in Human Wound Healing.

O-GlcNAcylation and Phosphorylation Crosstalk in Vascular Smooth Muscle Cells: Cellular and Therapeutic Significance in Cardiac and Vascular Pathologies (2025)
Journal Article
Bolanle, I. O., & Palmer, T. M. (2025). O-GlcNAcylation and Phosphorylation Crosstalk in Vascular Smooth Muscle Cells: Cellular and Therapeutic Significance in Cardiac and Vascular Pathologies. International Journal of Molecular Sciences, 26(7), Article 3303. https://doi.org/10.3390/ijms26073303

More than 400 different types of post-translational modifications (PTMs), including O-GlcNAcylation and phosphorylation, combine to co-ordinate almost all aspects of protein function. Often, these PTMs overlap and the specific relationship between O-... Read More about O-GlcNAcylation and Phosphorylation Crosstalk in Vascular Smooth Muscle Cells: Cellular and Therapeutic Significance in Cardiac and Vascular Pathologies.