cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway
(2017)
Journal Article
Aburima, A., Walladbegi, K., Wake, J. D., & Naseem, K. M. (2017). cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway. Journal of thrombosis and haemostasis : JTH, 15(8), 1668-1678. https://doi.org/10.1111/jth.13738
Essentials
Platelet shape change requires cytoskeletal rearrangement via myosin‐mediated actin contraction.
We investigated whether nitric oxide (NO) affected thrombin‐induced platelet shape change.
NO inhibits shape change, RhoA/ROCK signalling a...
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