Outputs (60)

Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. (2014)
Journal Article
Fahim, A., Crooks, M. G., Morice, A. H., & Hart, S. P. (2014). Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. Lung, 192(2), 277-284. https://doi.org/10.1007/s00408-013-9546-5

Purpose Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia and its prognosis is poor. Epidemiological evidence suggests an association of IPF with vascular disease and thrombotic tendency, which may be related to... Read More about Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis..

Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis (2012)
Journal Article
Fahim, A., Crooks, M., Wilmot, R., Campbell, A. P., Morice, A., & Hart, S. (2012). Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis. Respirology : official journal of the Asian Pacific Society of Respirology, 17(8), 1247-1252. https://doi.org/10.1111/j.1440-1843.2012.02231.x

Background and objective: Idiopathic pulmonary fibrosis (IPF) is the commonest idiopathic interstitial pneumonia and carries a poor prognosis. Epidemiological evidence suggests that patients with IPF have an increased risk of developing lung cancer.... Read More about Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis.

Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies (2012)
Journal Article
Fahim, A., Chong, M. C., Crooks, M. G., & Hart, S. P. (2012). Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies. Lung, 190(4), 451-458. https://doi.org/10.1007/s00408-012-9390-z

PurposeIdiopathic pulmonary fibrosis (IPF) is a restrictive fibrotic lung disease of uncertain etiology. Alveolar epithelial injury may be one of the inciting triggers in the pathogenesis of this disorder. We hypothesized that circulating antibodies... Read More about Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies.

Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN (2012)
Journal Article
Hart, S. P., Rossi, A. G., Haslett, C., & Dransfield, I. (2012). Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN. PLoS ONE, 7(3), e33142. https://doi.org/10.1371/journal.pone.0033142

Control of macrophage capacity for apoptotic cell clearance by soluble mediators such as cytokines, prostaglandins and lipoxins, serum proteins, and glucocorticoids may critically determine the rate at which inflammation resolves. Previous studies su... Read More about Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN.

Relationship Between Gastro-Oesophageal Reflux and Airway Diseases: The Airway Reflux Paradigm (2011)
Journal Article
Pacheco-Galván, A., Hart, S. P., & Morice, A. H. (2011). Relationship Between Gastro-Oesophageal Reflux and Airway Diseases: The Airway Reflux Paradigm. Archivos de Bronconeumología, 47(4), 195-203. https://doi.org/10.1016/S1579-2129%2811%2970046-5

Our understanding of the relationship between gastro-oesophageal reflux and respiratory disease has recently undergone important changes. The previous paradigm of airway reflux as synonymous with the classic gastro-oesophageal reflux disease (GORD) c... Read More about Relationship Between Gastro-Oesophageal Reflux and Airway Diseases: The Airway Reflux Paradigm.

Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis (2010)
Journal Article
Bournazos, S., Bournazou, I., Murchison, J. T., Wallace, W. A., McFarlane, P., Hirani, N., Simpson, A. J., Dransfield, I., & Hart, S. P. (2011). Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis. Respiration, 81(2), 142-149. https://doi.org/10.1159/000321997

Background: Several genes exhibit copy number variation (CNV), including FCGR3B which encodes the IgG receptor FcγRIIIb. Engagement of Fcγ receptors by IgG complexes may contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Objective... Read More about Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis.

Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression (2010)
Journal Article
Bournazos, S., Grinfeld, J., Alexander, K. M., Murchison, J. T., Wallace, W. A., McFarlane, P., Hirani, N., Simpson, A. J., Dransfield, I., & Hart, S. P. (2010). Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression. BMC Pulmonary Medicine, 10(1), Article ARTN 51. https://doi.org/10.1186/1471-2466-10-51

Background: A significant genetic component has been described for idiopathic pulmonary fibrosis (IPF). The R131H (rs1801274) polymorphism of the IgG receptor FcγRIIa determines receptor affinity for IgG subclasses and is associated with several chro... Read More about Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression.

Fcγ Receptor IIIb (CD16b) Polymorphisms are Associated with Susceptibility to Idiopathic Pulmonary Fibrosis (2010)
Journal Article
Bournazos, S., Bournazou, I., Murchison, J. T., Wallace, W. A., McFarlane, P., Hirani, N., Simpson, A. J., Dransfield, I., & Hart, S. P. (2010). Fcγ Receptor IIIb (CD16b) Polymorphisms are Associated with Susceptibility to Idiopathic Pulmonary Fibrosis. Lung, 188(6), 475-481. https://doi.org/10.1007/s00408-010-9262-3

An excess of neutrophils in the alveoli and lung interstitium has been described in idiopathic pulmonary fibrosis (IPF). Engagement of neutrophil Fcγ receptors with IgG complexes may contribute to the pathogenesis of IPF. The neutrophil FcγRIIIb rece... Read More about Fcγ Receptor IIIb (CD16b) Polymorphisms are Associated with Susceptibility to Idiopathic Pulmonary Fibrosis.

Association of FcγRIIa (CD32a) with lipid rafts regulates ligand binding activity (2009)
Journal Article
Bournazos, S., Hart, S. P., Chamberlain, L. H., Glennie, M. J., & Dransfield, I. (2009). Association of FcγRIIa (CD32a) with lipid rafts regulates ligand binding activity. Journal of Immunology, 182(12), 8026-8036. https://doi.org/10.4049/jimmunol.0900107

Binding of Igs to myeloid cells via FcR is a key event in the control of innate and acquired immunity. FcγRIIa (CD32a) is a receptor for multivalent IgG expressed predominantly by myeloid cells, and its association with microdomains rich in cholester... Read More about Association of FcγRIIa (CD32a) with lipid rafts regulates ligand binding activity.

Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status (2008)
Journal Article
Bournazos, S., Rennie, J., Hart, S. P., Fox, K. A. A., & Dransfield, I. (2008). Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(8), 1491-1498. https://doi.org/10.1161/ATVBAHA.108.167601

OBJECTIVE: Acute coronary diseases are characterized by elevated levels of circulating platelet-leukocyte complexes, raising the possibility that proinflammatory processes might be initiated in leukocytes after platelet adhesion. Here we examined the... Read More about Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status.