Outputs (949)

Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery (2025)
Journal Article
Lathan, R., Daysley, H., Ravindhran, B., Lim, A., Cutteridge, J., Sidapra, M., Long, J., Hitchman, L., Beltran-Alvarez, P., Carradice, D., Smith, G., & Chetter, I. (2025). Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery. BJS Open, 9(3), Article zraf015. https://doi.org/10.1093/bjsopen/zraf015

Background
There is sparse evidence of the relationship between environmental and financial costs of surgical-site infection. Identifying areas of high-cost burden would enable key targets for clinical interventions to aid in achieving the UK nation... Read More about Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery.

Negative pressure wound therapy for surgical wounds healing by secondary intention is not cost-effective (2025)
Journal Article
Saramago, P., Gkekas, A., Arundel, C. E., Chetter, I. C., & SWHSI-2 Trial Investigators. (2025). Negative pressure wound therapy for surgical wounds healing by secondary intention is not cost-effective. British journal of surgery, 112(5), Article znaf077. https://doi.org/10.1093/bjs/znaf077

Background: Negative pressure wound therapy (NPWT) has been used in clinical practice for surgical wounds healing by secondary intention (SWHSI), despite limited evidence regarding its clinical effectiveness and cost-effectiveness. The aim of this st... Read More about Negative pressure wound therapy for surgical wounds healing by secondary intention is not cost-effective.

Fixed Duration Ibrutinib‐Venetoclax, a Redefinition of the CLL Treatment Landscape (2025)
Journal Article
Molica, S., & Allsup, D. (2025). Fixed Duration Ibrutinib‐Venetoclax, a Redefinition of the CLL Treatment Landscape. Hematological Oncology, 43(3), Article e70088. https://doi.org/10.1002/hon.70088

The fixed-duration combination of ibrutinib and venetoclax (IV) has emerged as a highly effective therapeutic strategy for treating chronic lymphocytic leukemia (CLL), marking a significant shift in the treatment paradigm for this disease. Preclinica... Read More about Fixed Duration Ibrutinib‐Venetoclax, a Redefinition of the CLL Treatment Landscape.

Approaches to improve 12-month circuit primary patency and target lesion primary patency in arteriovenous fistulae: an umbrella review of systematic reviews and meta-analyses (2025)
Journal Article
Ravindhran, B., Parovic, M., Staniland, T., Howitt, A., Nazir, S., Lathan, R., Carradice, D., Smith, G., & Chetter, I. (in press). Approaches to improve 12-month circuit primary patency and target lesion primary patency in arteriovenous fistulae: an umbrella review of systematic reviews and meta-analyses. Journal of vascular access, https://doi.org/10.1177/11297298251332043

Background:
Clinical practice guidelines endorse arteriovenous fistulae (AVF) as the preferred form of vascular access. Despite recent advancements, concerns persist regarding variable AVF patency rates. This umbrella review aimed to evaluate and sy... Read More about Approaches to improve 12-month circuit primary patency and target lesion primary patency in arteriovenous fistulae: an umbrella review of systematic reviews and meta-analyses.

Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial (2025)
Journal Article
Arundel, C., Mandefield, L., Fairhurst, C., Baird, K., Gkekas, A., Saramago, P., & Chetter, I. (in press). Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial. Lancet, https://doi.org/10.1016/S0140-6736%2825%2900143-6

Background: Surgical wound healing by secondary intention (SWHSI) presents a substantial management and financial challenge. Negative pressure wound therapy (NPWT) has increasingly been used as a treatment despite an absence of comparative evidence o... Read More about Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial.

Editorial: Internal and external factors affecting polycystic ovary syndrome (2025)
Journal Article
Butler, A. E., Sathyapalan, T., Randeva, H., & Atkin, S. L. (2025). Editorial: Internal and external factors affecting polycystic ovary syndrome. Frontiers in endocrinology, 16, https://doi.org/10.3389/fendo.2025.1594718

Opening paragraph:
Polycystic ovary syndrome (PCOS) pathophysiology is modified by a multitude of internal and external factors that go far beyond the traditional stimulators and inhibitors of endocrine response and function. This Research Topic cal... Read More about Editorial: Internal and external factors affecting polycystic ovary syndrome.

Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study (2025)
Journal Article
Deshmukh, H., Newham, M., Ssemmondo, E., Pond, E., Kempegowda, P., Al-Abbood, M., Malabu, U., & Sathyapalan, T. (2025). Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study. Clinical Endocrinology, https://doi.org/10.1111/cen.15250

Introduction: Polycystic ovary syndrome (PCOS) presents complex challenges during pregnancy, affecting both maternal and neonatal health. This study aims to provide a comprehensive analysis of the demographic, social and clinical dimensions of PCOS i... Read More about Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study.

Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol (2025)
Journal Article
Wilmot, E. G., Ajjan, R. A., Cheah, Y. S., Choudhary, P., Cranston, I., Elliott, R. A., Evans, M., Iqbal, A., Kamaruddin, S., Barnard-Kelly, K., Lumb, A., Min, T., Moore, P., Narendran, P., Neupane, S., Rayman, G., Sathyapalan, T., Thabit, H., Yates, T., & Leelarathna, L. (2025). Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol. BMJ open, 15(4), Article e090154. https://doi.org/10.1136/bmjopen-2024-090154

Introduction Effective management of type 2 diabetes mellitus (T2DM) consists of lifestyle modification and therapy optimisation. While glycaemic monitoring can be used as a tool to guide these changes, this can be challenging with self-monitoring of... Read More about Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol.

ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection (2025)
Journal Article
Lathan, R., Hitchman, L., Walshaw, J., Ravindhran, B., Sidapra, M., Lim, A., Long, J., Totty, J., Carradice, D., Smith, G., & Chetter, I. (2025). ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection. International wound journal, 22(4), Article e70234. https://doi.org/10.1111/iwj.70234

Background
Remote assessment of surgical site infection(SSI) lacks sensitivity for diagnosis of SSI but current evidence has not evaluated whether a combination of photographs and questionnaires improves diagnostic accuracy. This study aims to devel... Read More about ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection.

A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol (2025)
Journal Article
Twiddy, M., Hitchman, L., Iglesias, C., Chetter, I. C., Russell, D., & Smith, G. (2025). A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol. International wound journal, 22(4), Article e70176. https://doi.org/10.1111/iwj.70176

The development of effective interventions for diabetes-related foot ulcers (DFU) healing is vital. This protocol outlines a pilot trial and qualitative study investigating ESWT in DFU healing. A pilot three arm placebo controlled double-blinded rand... Read More about A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol.