Outputs (956)

Editorial: Internal and external factors affecting polycystic ovary syndrome (2025)
Journal Article
Butler, A. E., Sathyapalan, T., Randeva, H., & Atkin, S. L. (2025). Editorial: Internal and external factors affecting polycystic ovary syndrome. Frontiers in endocrinology, 16, https://doi.org/10.3389/fendo.2025.1594718

Opening paragraph:
Polycystic ovary syndrome (PCOS) pathophysiology is modified by a multitude of internal and external factors that go far beyond the traditional stimulators and inhibitors of endocrine response and function. This Research Topic cal... Read More about Editorial: Internal and external factors affecting polycystic ovary syndrome.

Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study (2025)
Journal Article
Deshmukh, H., Newham, M., Ssemmondo, E., Pond, E., Kempegowda, P., Al-Abbood, M., Malabu, U., & Sathyapalan, T. (2025). Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study. Clinical Endocrinology, https://doi.org/10.1111/cen.15250

Introduction: Polycystic ovary syndrome (PCOS) presents complex challenges during pregnancy, affecting both maternal and neonatal health. This study aims to provide a comprehensive analysis of the demographic, social and clinical dimensions of PCOS i... Read More about Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study.

ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection (2025)
Journal Article
Lathan, R., Hitchman, L., Walshaw, J., Ravindhran, B., Sidapra, M., Lim, A., Long, J., Totty, J., Carradice, D., Smith, G., & Chetter, I. (2025). ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection. International wound journal, 22(4), Article e70234. https://doi.org/10.1111/iwj.70234

Background
Remote assessment of surgical site infection(SSI) lacks sensitivity for diagnosis of SSI but current evidence has not evaluated whether a combination of photographs and questionnaires improves diagnostic accuracy. This study aims to devel... Read More about ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection.

Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol (2025)
Journal Article
Wilmot, E. G., Ajjan, R. A., Cheah, Y. S., Choudhary, P., Cranston, I., Elliott, R. A., Evans, M., Iqbal, A., Kamaruddin, S., Barnard-Kelly, K., Lumb, A., Min, T., Moore, P., Narendran, P., Neupane, S., Rayman, G., Sathyapalan, T., Thabit, H., Yates, T., & Leelarathna, L. (2025). Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol. BMJ open, 15(4), Article e090154. https://doi.org/10.1136/bmjopen-2024-090154

Introduction Effective management of type 2 diabetes mellitus (T2DM) consists of lifestyle modification and therapy optimisation. While glycaemic monitoring can be used as a tool to guide these changes, this can be challenging with self-monitoring of... Read More about Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol.

A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol (2025)
Journal Article
Twiddy, M., Hitchman, L., Iglesias, C., Chetter, I. C., Russell, D., & Smith, G. (2025). A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol. International wound journal, 22(4), Article e70176. https://doi.org/10.1111/iwj.70176

The development of effective interventions for diabetes-related foot ulcers (DFU) healing is vital. This protocol outlines a pilot trial and qualitative study investigating ESWT in DFU healing. A pilot three arm placebo controlled double-blinded rand... Read More about A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol.

Association of Complement Proteins with C Reactive Protein in Non-Obese Women with and Without Polycystic Ovary Syndrome (2025)
Journal Article
Butler, A. E., Moin, A. S. M., Begam, H. H., Waris, S., Azeez, J. M., Sathyapalan, T., Atkin, S. L., & Brennan, E. (2025). Association of Complement Proteins with C Reactive Protein in Non-Obese Women with and Without Polycystic Ovary Syndrome. International Journal of Molecular Sciences, 26(7), Article 3008. https://doi.org/10.3390/ijms26073008

Complement proteins are increased in polycystic ovary syndrome (PCOS), as are markers of inflammation, such as the C-reactive protein (CRP); however, both may be increased in obesity. We hypothesised that body mass index (BMI)-driven CRP would compar... Read More about Association of Complement Proteins with C Reactive Protein in Non-Obese Women with and Without Polycystic Ovary Syndrome.

Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial (2025)
Journal Article
Crooks, M. G., Wright, C., Hart, S., Allgar, V., English, A., Swan, F., Dyson, J., Richardson, G., Twiddy, M., Cohen, J., Simpson, A., Huang, C., Sykes, D. L., & Johnson, M. (2025). Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial. BMJ Open Respiratory Research, 12(1), Article e002327. https://doi.org/10.1136/bmjresp-2024-002327

Introduction Breathlessness is common and impairs the quality of life of people with idiopathic pulmonary fibrosis (IPF) and non-IPF fibrotic interstitial lung diseases (ILD). We report the findings of a multicentre, fast-track (wait-list), mixed-met... Read More about Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial.

A Cross-Sectional Exploratory Study of Rat Sarcoid (Ras) Activation in Women with and Without Polycystic Ovary Syndrome (2025)
Journal Article
Niinuma, S. A., Habib, H., Takemoto, A. S. N., Das, P., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2025). A Cross-Sectional Exploratory Study of Rat Sarcoid (Ras) Activation in Women with and Without Polycystic Ovary Syndrome. Cells, 14(5), Article 377. https://doi.org/10.3390/cells14050377

Objective: Rat sarcoma (Ras) proteins, Kirsten, Harvey, and Neuroblastoma rat sarcoma viral oncogene homolog (KRAS, HRAS, and NRAS, respectively), are a family of GTPases, which are key regulators of cellular growth, differentiation, and apoptosis th... Read More about A Cross-Sectional Exploratory Study of Rat Sarcoid (Ras) Activation in Women with and Without Polycystic Ovary Syndrome.

Comparative Performance Of Clinician And Computational Approaches In Forecasting Adverse Outcomes In Intermittent Claudication (2025)
Presentation / Conference Contribution
Ravindhran, B., Cutteridge, J., Pymer, S., Prosser, J., Lim, A., Hemadneh, M., Nazir, S., Mohamed, A., Lathan, R., Johnson, B. F., Smith, G., Carradice, D., & Chetter, I. C. (2025, February). Comparative Performance Of Clinician And Computational Approaches In Forecasting Adverse Outcomes In Intermittent Claudication. Presented at Vascular & Endovascular Surgery Society 49th Annual Winter Meeting, Breckenridge, Colorado

Introduction and Objectives
Machine learning (ML) based prediction modelling has demonstrated superior abilities in analysing non-linear data with complex relationships. Pilot work in this work-stream has shown that ML techniques can accurately fore... Read More about Comparative Performance Of Clinician And Computational Approaches In Forecasting Adverse Outcomes In Intermittent Claudication.

An Exploration of Factors Affecting Timely Referral of Patients with Chronic Limb-Threatening Ischaemia (2025)
Thesis
Atkins, E. (2025). An Exploration of Factors Affecting Timely Referral of Patients with Chronic Limb-Threatening Ischaemia. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/5130250

Chronic limb-threatening ischaemia (CLTI) is the end-stage of peripheral arterial disease. It is associated with significant risks of limb loss and mortality, which increase with delays to revascularisation. There is currently little understanding of... Read More about An Exploration of Factors Affecting Timely Referral of Patients with Chronic Limb-Threatening Ischaemia.