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Outputs (789)

Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site (2023)
Journal Article
Crooks, M. G., Crowther, L., Cummings, H., Cohen, J., Huang, C., Pitel, L., Pearson, M., Morice, A., Turgoose, J., Faruqi, S., Watt, M., Morris, T., & Xu, Y. (2023). Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site. ERJ Open Research, 9(3), Article 00685-2022. https://doi.org/10.1183/23120541.00685-2022

Aim: Short-acting β2-agonist (SABA) overuse adversely impacts asthma-related outcomes and the environment. The SABA rEductioN Through ImplemeNting Hull asthma guidELines (SENTINEL) programme aims to reduce SABA overuse through supported implementatio... Read More about Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site.

Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial) (2023)
Journal Article
Sousa, M. S., Martin, P., Johnson, M. J., Lind, M., Maddocks, M., Bullock, A., Agar, M., Chang, S., Kochovska, S., Kinchin, I., Morgan, D., Fazekas, B., Razmovski-Naumovski, V., Lee, J. T., Itchins, M., Bray, V., & Currow, D. C. (2023). Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial). PLoS ONE, 18(5 May), Article e0285850. https://doi.org/10.1371/journal.pone.0285850

Anorexia is experienced by most people with lung cancer during the course of their disease and treatment. Anorexia reduces response to chemotherapy and the ability of patients to cope with, and complete their treatment leading to greater morbidity, p... Read More about Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial).

Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells (2023)
Thesis
Haque, F. Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4371279

The premalignant pancreatic cellular genotype can remain stable for years before rapid malignant transformation, often associated with inflammation. Tissue factor (TF) is an inflammatory modulator regulated by factor VIIa (fVIIa) for its levels and a... Read More about Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells.

HDL-Associated Proteins in Subjects with Polycystic Ovary Syndrome: A Proteomic Study (2023)
Journal Article
Butler, A. E., Moin, A. S. M., Reiner, Ž., Sathyapalan, T., Jamialahmadi, T., Sahebkar, A., & Atkin, S. L. (2023). HDL-Associated Proteins in Subjects with Polycystic Ovary Syndrome: A Proteomic Study. Cells, 12(6), https://doi.org/10.3390/cells12060855

INTRODUCTION: Serum lipoproteins, with the exception of high-density lipoprotein cholesterol (HDL-C), are increased in polycystic ovary syndrome (PCOS) and their levels may reflect the associated obesity and insulin resistance, but the nature of this... Read More about HDL-Associated Proteins in Subjects with Polycystic Ovary Syndrome: A Proteomic Study.

The long-term impact of glucose monitoring with the FreeStyle Libre on glycaemic control and hypoglycaemia awareness in people with type1 diabetes: Insights from the Association of British Clinical Diabetologists national audit (2023)
Journal Article
Shah, N., Deshmukh, H., Wilmot, E. G., Patmore, J., Christian, P., Barnes, D. J., Walton, C., Ryder, R. E. J., & Sathyapalan, T. (2023). The long-term impact of glucose monitoring with the FreeStyle Libre on glycaemic control and hypoglycaemia awareness in people with type1 diabetes: Insights from the Association of British Clinical Diabetologists national audit. Diabetic medicine, 40(6), Article e15070. https://doi.org/10.1111/dme.15070

Aims: To investigate the change in glycated haemoglobin (HbA1c), hypoglycaemia awareness and diabetes-related distress in people with type 1 diabetes (T1D) using FreeStyle Libre (FSL) over a 2-year follow-up period. Methods: FSL user data from U.K wi... Read More about The long-term impact of glucose monitoring with the FreeStyle Libre on glycaemic control and hypoglycaemia awareness in people with type1 diabetes: Insights from the Association of British Clinical Diabetologists national audit.

PCSK6 and Survival in Idiopathic Pulmonary Fibrosis (2023)
Journal Article
Oldham, J. M., Allen, R. J., Lorenzo-Salazar, J. M., Molyneaux, P. L., Ma, S. F., Joseph, C., …Noth, I. (2023). PCSK6 and Survival in Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 207(11), 1515-1524. https://doi.org/10.1164/rccm.202205-0845OC

Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by limited treatment options and high mortality. A better understanding of the molecular drivers of IPF progression is needed. Objectives: To identify and validate... Read More about PCSK6 and Survival in Idiopathic Pulmonary Fibrosis.

Chronic cough—the limitation and advances in assessment techniques (2022)
Journal Article
Zhang, M., Sykes, D. L., Brindle, K., Sadofsky, L. R., & Morice, A. H. (2022). Chronic cough—the limitation and advances in assessment techniques. Journal of thoracic disease, 14(12), 5097-5119. https://doi.org/10.21037/jtd-22-874

Accurate and consistent assessments of cough are essential to advance the understanding of the mechanisms of cough and individualised the management of patients. Considerable progress has been made in this work. Here we reviewed the currently availab... Read More about Chronic cough—the limitation and advances in assessment techniques.

Classical and alternate complement factor overexpression in non-obese weight matched women with polycystic ovary syndrome does not correlate with vitamin D (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Butler, A. E., & Atkin, S. L. (2022). Classical and alternate complement factor overexpression in non-obese weight matched women with polycystic ovary syndrome does not correlate with vitamin D. Frontiers in endocrinology, 13, Article 935750. https://doi.org/10.3389/fendo.2022.935750

Introduction: Women with polycystic ovary syndrome (PCOS) exhibit complement factor expression changes that may be obesity-driven rather than an intrinsic facet of PCOS; furthermore, complement changes have been associated with vitamin D deficiency,... Read More about Classical and alternate complement factor overexpression in non-obese weight matched women with polycystic ovary syndrome does not correlate with vitamin D.