Outputs (375)

Respiratory adverse effects of opioids for breathlessness: a systematic review and meta-analysis (2017)
Journal Article
Verberkt, C. A., van den Beuken-van Everdingen, M. H., Schols, J. M., Datla, S., Dirksen, C. D., Johnson, M. J., van Kuijk, S. M., Wouters, E. F., & Janssen, D. J. (2017). Respiratory adverse effects of opioids for breathlessness: a systematic review and meta-analysis. European respiratory journal, 50(5), 1701153. https://doi.org/10.1183/13993003.01153-2017

Background: Previous studies have shown that opioids can reduce chronic breathlessness in advanced disease. However, physicians remain reluctant to prescribe opioids for these patients, commonly due to fear of respiratory adverse effects. Aim: To sys... Read More about Respiratory adverse effects of opioids for breathlessness: a systematic review and meta-analysis.

What is the impact of population ageing on the future provision of end-of-life care? Population-based projections of place of death (2017)
Journal Article
Bone, A. E., Gomes, B., Etkind, S. N., Verne, J., Murtagh, F. E., Evans, C. J., & Higginson, I. J. (2018). What is the impact of population ageing on the future provision of end-of-life care? Population-based projections of place of death. Palliative medicine, 32(2), 329-336. https://doi.org/10.1177/0269216317734435

© 2017, © The Author(s) 2017. Background: Population ageing represents a global challenge for future end-of-life care. Given new trends in place of death, it is vital to examine where the rising number of deaths will occur in future years and implica... Read More about What is the impact of population ageing on the future provision of end-of-life care? Population-based projections of place of death.

Prescribing non-opioid drugs in end-stage kidney disease (2017)
Journal Article
Wilcock, A., Charlesworth, S., Twycross, R., Waddington, A., Worthington, O., Murtagh, F. E., Beavis, J., King, S., Mihalyo, M., & Kotlinska-Lemieszek, A. (2017). Prescribing non-opioid drugs in end-stage kidney disease. Journal of pain and symptom management, 54(5), 776-787. https://doi.org/10.1016/j.jpainsymman.2017.08.014

Palliative care services are increasingly involved in the care of patients with chronic kidney disease, either alone or as a comorbid condition. Because renal impairment often changes the pharmacokinetic and/or pharmacodynamic effects of a drug, this... Read More about Prescribing non-opioid drugs in end-stage kidney disease.

Systematic review of pharmacological therapies for the management of ischaemic pain in patients with non-reconstructable critical limb ischaemia (2017)
Journal Article
Laoire, Á. N., & Murtagh, F. E. (2018). Systematic review of pharmacological therapies for the management of ischaemic pain in patients with non-reconstructable critical limb ischaemia. BMJ supportive & palliative care, 8(4), 400-410. https://doi.org/10.1136/bmjspcare-2017-001359

Background Critical limb ischaemia (CLI) is a severe manifestation of peripheral arterial disease, characterised by chronic ischaemic rest pain, ulcers or gangrene. Management of ischaemic pain is challenging in patients with no options for revascula... Read More about Systematic review of pharmacological therapies for the management of ischaemic pain in patients with non-reconstructable critical limb ischaemia.

Contributions of a hand-held fan to self-management of chronic breathlessness (2017)
Journal Article
Luckett, T., Phillips, J., Johnson, M. J., Farquhar, M., Swan, F., Assen, T., Bhattarai, P., & Booth, S. (2017). Contributions of a hand-held fan to self-management of chronic breathlessness. European respiratory journal, 50(2), Article 1700262. https://doi.org/10.1183/13993003.00262-2017

© ERS 2017. This study explored the benefits of a hand-held fan as perceived by patients with chronic breathlessness and their carers. A secondary multimethod analysis was conducted of interview data collected in three clinical trials. Two researcher... Read More about Contributions of a hand-held fan to self-management of chronic breathlessness.

Phase of Illness in palliative care: Cross-sectional analysis of clinical data from community, hospital and hospice patients (2017)
Journal Article
Mather, H., Guo, P., Firth, A., Davies, J. M., Sykes, N., Landon, A., & Murtagh, F. E. (2018). Phase of Illness in palliative care: Cross-sectional analysis of clinical data from community, hospital and hospice patients. Palliative medicine, 32(2), 404-412. https://doi.org/10.1177/0269216317727157

© 2017, © The Author(s) 2017. Background: Phase of Illness describes stages of advanced illness according to care needs of the individual, family and suitability of care plan. There is limited evidence on its association with other measures of sympto... Read More about Phase of Illness in palliative care: Cross-sectional analysis of clinical data from community, hospital and hospice patients.

Pharmacovigilance in hospice/palliative care: Net effect of haloperidol for nausea or vomiting (2017)
Journal Article
Digges, M., Hussein, A., Wilcock, A., Crawford, G. B., Boland, J. W., Agar, M. R., Sinnarajah, A., Currow, D. C., & Johnson, M. J. (2018). Pharmacovigilance in hospice/palliative care: Net effect of haloperidol for nausea or vomiting. Journal of palliative medicine, 21(1), 37-43. https://doi.org/10.1089/jpm.2017.0159

Background Haloperidol is widely prescribed as an anti-emetic in patients receiving palliative care, but there is limited evidence to support and refine its use. Objective To explore the immediate and short-term net clinical effects of haloperidol wh... Read More about Pharmacovigilance in hospice/palliative care: Net effect of haloperidol for nausea or vomiting.

A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion And Morphine Sulfate (BEAMS) study protocol (2017)
Journal Article
Currow, D., Watts, G. J., Johnson, M., McDonald, C. F., Miners, J. O., Somogyi, A. A., Denehy, L., McCaffrey, N., Eckert, D. J., McCloud, P., Louw, S., Lam, L., Greene, A., Fazekas, B., Clark, K. C., Fong, K., Agar, M. R., Joshi, R., Kilbreath, S., Ferreira, D., & Ekström, M. (2017). A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion And Morphine Sulfate (BEAMS) study protocol. BMJ open, 7(7), 1-18. https://doi.org/10.1136/bmjopen-2017-018100

© Article author(s). Introduction Chronic breathlessness is highly prevalent and distressing to patients and families. No medication is registered for its symptomatic reduction. The strongest evidence is for regular, low-dose, extended-release (ER) o... Read More about A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathlessness, Exertion And Morphine Sulfate (BEAMS) study protocol.

Influence of opioids on immune function in patients with cancer pain: from bench to bedside (2017)
Journal Article
Boland, J. W., & Pockley, A. G. (in press). Influence of opioids on immune function in patients with cancer pain: from bench to bedside. British Journal of Pharmacology, 175(14), 2726-2736. https://doi.org/10.1111/bph.13903

In patients with cancer, opioids are principally used for the management of acute surgical and chronic cancer-related pain. However, opioids have many non-analgesic effects, including direct and indirect effects on cancer cells and on anti-tumour imm... Read More about Influence of opioids on immune function in patients with cancer pain: from bench to bedside.

Social and professional influences on antimicrobial prescribing for doctors-in-training: A realist review (2017)
Journal Article
Papoutsi, C., Mattick, K., Pearson, M., Brennan, N., Briscoe, S., & Wong, G. (2017). Social and professional influences on antimicrobial prescribing for doctors-in-training: A realist review. The journal of antimicrobial chemotherapy, 72(9), 2418-2430. https://doi.org/10.1093/jac/dkx194

Background
Antimicrobial resistance has led to widespread implementation of interventions for appropriate prescribing. However, such interventions are often adopted without an adequate understanding of the challenges facing doctors-in-training as key... Read More about Social and professional influences on antimicrobial prescribing for doctors-in-training: A realist review.