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The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study

Sathyapalan, Thozhukat; Dawson, Alison J.; Rigby, Alan S.; Thatcher, Natalie J.; Kilpatrick, Eric S.; Atkin, Stephen L.

Authors

Alison J. Dawson

Natalie J. Thatcher

Eric S. Kilpatrick

Stephen L. Atkin



Abstract

Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on thyroid function in subclinical hypothyroidism. Design and setting: Randomized, double-blind, crossover study. Participants: Forty four patients with subclinical hypothyroidism. Intervention: Participants were randomly allocated to either 66 mg phytoestrogen with 30 g soy protein (active) or 0 mg phytoestrogen with 30 g soy protein (placebo) supplementation for 8 weeks, washed out for 8 weeks and then crossed over for another 8 week period. Main outcome measures: The primary outcome was progression to overt hypothyroidism with the secondary outcome measures were changes in thyroid function tests. Results: Two patients in this trial progressed into overt hypothyroidism after high dose phytoestrogen supplementation. TSH, free thyroxine and triiodothyronine did not differ between groups. Conclusion: A pharmacological dose of 66 mg of soy phytoestrogens did not increase the overt thyroid failure rate or alter thyroid function tests in patients with subclinical hypothyroidism.

Citation

Sathyapalan, T., Dawson, A. J., Rigby, A. S., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2018). The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study. Frontiers in endocrinology, 9(SEP), Article 531. https://doi.org/10.3389/fendo.2018.00531

Journal Article Type Article
Acceptance Date Aug 22, 2018
Online Publication Date Sep 11, 2018
Publication Date Sep 11, 2018
Deposit Date Sep 11, 2018
Publicly Available Date Mar 29, 2024
Journal Frontiers in Endocrinology | www.frontiersin.org
Print ISSN 1664-2392
Electronic ISSN 1664-2392
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 9
Issue SEP
Article Number 531
DOI https://doi.org/10.3389/fendo.2018.00531
Keywords Subclinical hypothyroidisim; Phytoestrogen; Isoflavones; Daidzein; Genistein glucosides
Public URL https://hull-repository.worktribe.com/output/1036782
Publisher URL https://www.frontiersin.org/articles/10.3389/fendo.2018.00531/full

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Copyright Statement
© 2018 Sathyapalan, Dawson, Rigby, Thatcher, Kilpatrick and Atkin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.





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