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Polycystic Ovary Syndrome: Implication for Drug Metabolism on Assisted Reproductive Techniques—A Literature Review

Reyes-Muñoz, Enrique; Sathyapalan, Thozhukat; Rossetti, Paola; Shah, Mohsin; Long, Min; Buscema, Massimo; Valenti, Gaetano; La Rosa, Valentina Lucia; Cianci, Stefano; Vitale, Salvatore Giovanni


Enrique Reyes-Muñoz

Paola Rossetti

Mohsin Shah

Min Long

Massimo Buscema

Gaetano Valenti

Valentina Lucia La Rosa

Stefano Cianci

Salvatore Giovanni Vitale


Polycystic ovary syndrome (PCOS) affects 6–10% of women and could be considered one of the most common endocrine alterations in women of reproductive age. The syndrome is characterized by several hormonal and metabolic alterations, including insulin resistance and hyperandrogenism, which play a severe detrimental role in the patient’s fertility. We aimed to offer an overview about drug metabolism in the PCOS population. Nevertheless, we did not find any study that directly compared drug metabolism between PCOS and healthy women. We therefore decided to summarize briefly how hormonal and insulin sensitizer drugs act differently in healthy and PCOS women, who show altered steroidogenesis by theca cells and metabolic imbalance, focusing especially on assisted reproductive techniques. To date, data about drug metabolism in the PCOS population appears to be extremely limited. This important gap could have significant implications for therapeutic approaches and future perspectives: the dosage of drugs commonly used for the treatment of PCOS women should be tailored according to each patient’s characteristics; we should implement new clinical trials in order to identify the best pharmacologic strategy for PCOS patients undergoing in vitro fertilization (IVF); it would be advisable to create an international expert panel to investigate the drug metabolism in the PCOS population.


Reyes-Muñoz, E., Sathyapalan, T., Rossetti, P., Shah, M., Long, M., Buscema, M., …Vitale, S. G. (2018). Polycystic Ovary Syndrome: Implication for Drug Metabolism on Assisted Reproductive Techniques—A Literature Review. Advances in Therapy, 35(11), 1805-1815.

Journal Article Type Review
Acceptance Date Oct 4, 2018
Online Publication Date Oct 11, 2018
Publication Date Nov 1, 2018
Deposit Date Oct 13, 2018
Publicly Available Date Oct 15, 2018
Journal Advances in Therapy
Print ISSN 0741-238X
Electronic ISSN 1865-8652
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 35
Issue 11
Pages 1805-1815
Keywords Pharmacology (medical); General Medicine
Public URL
Publisher URL


Review (350 Kb)

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© The Author(s) 2018<br /> <br /> This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (, which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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