Macrocycle encapsulation triggered supramolecular pKa shift: A fluorescence indicator for detecting octreotide in aqueous solution

Yin, Ting; Zhang, Sheng; Li, Mengxuan; Redshaw, Carl; Ni, Xin-Long

Abstract

Supramolecular pKa shifts, have attracted much attention in catalytic and biomimetic studies because of their excellent property to modify the acidity or basicity of the substrate in aqueous media by host-guest inclusion. Here, Fluorescence indicator displacement based on cucurbit[8]uril encapsulation of the dye acridine leads to the recognition of the peptide drug octreotide in aqueous solution via distinctive pH signals was expolited. This is thought to be a result of competitive host-guest interactions involving a supramolecular pKa shift.

Citation

Yin, T., Zhang, S., Li, M., Redshaw, C., & Ni, X. (2019). Macrocycle encapsulation triggered supramolecular pKa shift: A fluorescence indicator for detecting octreotide in aqueous solution. Sensors and actuators. B, Chemical, 281, 568-573. https://doi.org/10.1016/j.snb.2018.10.136

• Journal Article Type: Article
• Acceptance Date: Oct 26, 2018
• Online Publication Date: Oct 29, 2018
• Publication Date: Feb 15, 2019
• Deposit Date: Nov 6, 2018
• Publicly Available Date: Oct 30, 2019
• Journal: Sensors and Actuators B: Chemical
• Print ISSN: 0925-4005
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 281
• Pages: 568-573
• DOI: https://doi.org/10.1016/j.snb.2018.10.136
• Keywords: Supramolecular pKa shift; Cucurbit[8]uril; Fluorescence indicator displacement; Drug octreotide; Acridine
• Public URL: https://hull-repository.worktribe.com/output/1144910
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0925400518319130?via%3Dihub
• Additional Information: This article is maintained by: Elsevier; Article Title: Macrocycle encapsulation triggered supramolecular pKa shift: A fluorescence indicator for detecting octreotide in aqueous solution; Journal Title: Sensors and Actuators B: Chemical; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.snb.2018.10.136; Content Type: article; Copyright: © 2018 Elsevier B.V. All rights reserved.