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3D vasculature segmentation using localized hybrid level-set method

Hong, Qingqi; Li, Qingde; Wang, Beizhan; Li, Yan; Yao, Junfeng; Liu, Kunhong; Wu, Qingqiang


Qingqi Hong

Beizhan Wang

Yan Li

Junfeng Yao

Kunhong Liu

Qingqiang Wu


Background: Intensity inhomogeneity occurs in many medical images, especially in vessel images. Overcoming the difficulty due to image inhomogeneity is crucial for the segmentation of vessel image. Methods: This paper proposes a localized hybrid level-set method for the segmentation of 3D vessel image. The proposed method integrates both local region information and boundary information for vessel segmentation, which is essential for the accurate extraction of tiny vessel structures. The local intensity information is firstly embedded into a region-based contour model, and then incorporated into the level-set formulation of the geodesic active contour model. Compared with the preset global threshold based method, the use of automatically calculated local thresholds enables the extraction of the local image information, which is essential for the segmentation of vessel images. Results: Experiments carried out on the segmentation of 3D vessel images demonstrate the strengths of using locally specified dynamic thresholds in our level-set method. Furthermore, both qualitative comparison and quantitative validations have been performed to evaluate the effectiveness of our proposed model. Conclusions: Experimental results and validations demonstrate that our proposed model can achieve more promising segmentation results than the original hybrid method does.


Hong, Q., Li, Q., Wang, B., Li, Y., Yao, J., Liu, K., & Wu, Q. (2014). 3D vasculature segmentation using localized hybrid level-set method. BioMedical Engineering OnLine, 13(1), 169.

Journal Article Type Article
Acceptance Date Nov 27, 2014
Online Publication Date Dec 16, 2014
Publication Date 2014
Deposit Date Jan 2, 2019
Publicly Available Date Jan 3, 2019
Journal BioMedical Engineering Online
Print ISSN 1475-925X
Electronic ISSN 1475-925X
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 13
Issue 1
Pages 169
Keywords Segmentation; Vessel image; Level-set; Intensity inhomogeneity
Public URL
Publisher URL


Published article (2.8 Mb)

Copyright Statement
© Hong et al.; licensee BioMed Central. 2014<br /> This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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