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Association of vitamin D metabolites with embryo development and fertilization in women with and without PCOS undergoing subfertility treatment

Cunningham, Thomas Keith; Allgar, Victoria; Dargham, Soha R.; Kilpatrick, Eric; Sathyapalan, Thozhukat; Maguiness, Stephen; Mokhtar Rudin, Haira R.; Abdul Ghani, Nour M.; Latiff, Aishah; Atkin, Stephen L.

Authors

Thomas Keith Cunningham

Victoria Allgar

Soha R. Dargham

Eric Kilpatrick

Stephen Maguiness

Haira R. Mokhtar Rudin

Nour M. Abdul Ghani

Aishah Latiff

Stephen L. Atkin



Abstract

Objective: The relationship between fertilization rates and 1,25-dihydroxyvitamin D (1,25(OH)2D3), 25-hydroxyvitamin D2 (25(OH)D2), 25-hydroxyvitamin D3 (25(OH)D3), 24,25-dihydroxyvitamin D (24,25(OH)2D3), and 25-hydroxy-3epi-Vitamin D3 (3epi25(OH)D3) concentrations in age and weight matched women with and without PCOS was studied. Methods: Fifty nine non-obese women, 29 with PCOS, and 30 non-PCOS undergoing IVF, matched for age and weight were included. Serum vitamin D metabolites were taken the menstrual cycle prior to commencing controlled ovarian hyperstimulation. Results: Vitamin D metabolites did not differ between PCOS and controls; however, 25(OH)D3 correlated with embryo fertilization rates in PCOS patients alone (p = 0.03). For all subjects, 3epi25(OH)D3 correlated with fertilization rate (p < 0.04) and negatively with HOMA-IR (p < 0.02); 25(OH)D2 correlated with cleavage rate, G3D3 and blastocyst (p < 0.05; p < 0.009; p < 0.002, respectively). 24,25(OH)2D3 correlated with AMH, antral follicle count, eggs retrieved and top quality embryos (G3D3) (p < 0.03; p < 0.003; p < 0.009; p < 0.002, respectively), and negatively with HOMA-IR (p < 0.01). 1,25(OH)2D3 did not correlate with any of the metabolic or embryo parameters. In slim PCOS, 25(OH)D3 correlated with increased fertilization rates in PCOS, but other vitamin D parameters did not differ to matched controls. Conclusion: 3epi25(OH)D3, 25(OH)D2, and 24,25(OH)2D3, but not 1,25(OH)2D3, were associated with embryo parameters suggesting that vitamin D metabolites other than 1,25(OH)2D3 are important in fertility.

Citation

Cunningham, T. K., Allgar, V., Dargham, S. R., Kilpatrick, E., Sathyapalan, T., Maguiness, S., …Atkin, S. L. (2019). Association of vitamin D metabolites with embryo development and fertilization in women with and without PCOS undergoing subfertility treatment. Frontiers in endocrinology, 10(JAN), Article 13. https://doi.org/10.3389/fendo.2019.00013

Journal Article Type Article
Acceptance Date Jan 10, 2019
Online Publication Date Jan 29, 2019
Publication Date Jan 29, 2019
Deposit Date Feb 1, 2019
Publicly Available Date Mar 28, 2024
Journal Frontiers in Endocrinology
Print ISSN 1664-2392
Electronic ISSN 1664-2392
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 10
Issue JAN
Article Number 13
DOI https://doi.org/10.3389/fendo.2019.00013
Keywords Vitamin D; Vitamin D epimers; Vitamin D metabolites; Fertilization rates; PCOS
Public URL https://hull-repository.worktribe.com/output/1261391

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Copyright Statement
© 2019 Cunningham, Allgar, Dargham, Kilpatrick, Sathyapalan, Maguiness, Mokhtar Rudin, Abdul Ghani, Latiff and Atkin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.





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