Harnessing CRISPR/Cas9 technology in cardiovascular disease

Rezaei, Hamzeh; khadempar, Saedeh; Farahani, Najmeh; Hosseingholi, Elaheh Zadeh; hayat, Seyed Mohammad Gheibi; Sathyapalan, Thozhukat; Sahebkar, Amir hossein

Abstract

The CRISPR/Cas9 system is a precisely targeted bacterial defense system, used to control invading viruses. This technology has many potential applications including genetic changes in somatic and germ cells and the creation of knockout animals. Compared to other genome editing techniques such as zinc-finger nucleases and transcription activator-like effector nucleases (TALENS), the CRISPR/Cas9 system is much easier and more efficient. Most importantly, the multifunctional capacity of this technology allows simultaneous editing of several genes. The CRISPR/Cas9 system also potentially has the ability to prevent and treat human diseases. The present article addresses some key points related to the use of the CRISPR/Cas9 system as a powerful tool in cardiovascular research and as a new strategy for the treatment of cardiovascular disease (CVD).

Citation

Rezaei, H., khadempar, S., Farahani, N., Hosseingholi, E. Z., hayat, S. M. G., Sathyapalan, T., & Sahebkar, A. H. (2020). Harnessing CRISPR/Cas9 technology in cardiovascular disease. Trends in Cardiovascular Medicine, 30(2), 93-101. https://doi.org/10.1016/j.tcm.2019.03.005

• Journal Article Type: Article
• Acceptance Date: Mar 14, 2019
• Online Publication Date: Mar 26, 2019
• Publication Date: Feb 1, 2020
• Deposit Date: Mar 30, 2019
• Publicly Available Date: Mar 27, 2020
• Journal: Trends in Cardiovascular Medicine
• Print ISSN: 1050-1738
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 2
• Pages: 93-101
• DOI: https://doi.org/10.1016/j.tcm.2019.03.005
• Keywords: CRISPR/Cas9; Genome editing; Cardiovascular disease
• Public URL: https://hull-repository.worktribe.com/output/1479289
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1050173819300428?via%3Dihub
• Additional Information: This is the accepted manuscript of an article published in Trends in cardiovascular medicine, 2019. The version of record is available at the DOI link in this record.
• Contract Date: Apr 1, 2019