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Harnessing CRISPR/Cas9 technology in cardiovascular disease

Rezaei, Hamzeh; Khadempar, Saedeh; Farahani, Najmeh; Hosseingholi, Elaheh Zadeh; Hayat, Seyed Mohammad Gheibi; Sathyapalan, Thozhukat; Sahebkar, Amir Hossein

Authors

Hamzeh Rezaei

Saedeh Khadempar

Najmeh Farahani

Elaheh Zadeh Hosseingholi

Seyed Mohammad Gheibi Hayat

Thozhukat Sathyapalan

Amir Hossein Sahebkar



Abstract

The CRISPR/Cas9 system is a precisely targeted bacterial defense system, used to control invading viruses. This technology has many potential applications including genetic changes in somatic and germ cells and the creation of knockout animals. Compared to other genome editing techniques such as zinc-finger nucleases and transcription activator-like effector nucleases (TALENS), the CRISPR/Cas9 system is much easier and more efficient. Most importantly, the multifunctional capacity of this technology allows simultaneous editing of several genes. The CRISPR/Cas9 system also potentially has the ability to prevent and treat human diseases. The present article addresses some key points related to the use of the CRISPR/Cas9 system as a powerful tool in cardiovascular research and as a new strategy for the treatment of cardiovascular disease (CVD).

Journal Article Type Article
Journal Trends in Cardiovascular Medicine
Print ISSN 1050-1738
Publisher Elsevier
Peer Reviewed Peer Reviewed
APA6 Citation Rezaei, H., Khadempar, S., Farahani, N., Hosseingholi, E. Z., Hayat, S. M. G., Sathyapalan, T., & Sahebkar, A. H. (in press). Harnessing CRISPR/Cas9 technology in cardiovascular disease. Trends in Cardiovascular Medicine, https://doi.org/10.1016/j.tcm.2019.03.005
DOI https://doi.org/10.1016/j.tcm.2019.03.005
Keywords CRISPR/Cas9; Genome editing; Cardiovascular disease
Publisher URL https://www.sciencedirect.com/science/article/pii/S1050173819300428?via%3Dihub
Additional Information This is the accepted manuscript of an article published in Trends in cardiovascular medicine, 2019. The version of record is available at the DOI link in this record.

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