Maryam Paseban
Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in diabetes mellitus
Paseban, Maryam; Mohebbati, Reza; Niazmand, Saeed; Sathyapalan, Thozhukat; Sahebkar, Amirhossein
Authors
Reza Mohebbati
Saeed Niazmand
Professor Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk
Professor of Diabetes, Endocrinology and Metabolism
Amirhossein Sahebkar
Abstract
Objective: The aim of this study was to investigate the effect of combined intake of a high dose of aspirin, atorvastatin, captopril and metformin on oxidative stress in the brain cortex and hippocampus of streptozotocin (STZ)-induced diabetic rats. Material and methods: Rats were randomly divided into the following 11 groups: control and diabetic (D), as well as 9 groups that were treated with metformin (M, 300 mg/kg) or aspirin (ASA, 120 mg/kg) alone or in different combinations with captopril (C, 50 mg/kg) and/or atorvastatin (AT, 40 mg/kg) as follows: (D + M), (D + ASA), (D + M + ASA), (D + M + C), (D + M + AT), (D + M + C + ASA), (D + M + C + AT), (D + M + AT + ASA) and (D + M + C + AT + ASA). The rats in treatment groups received drugs by gavage daily for six weeks. Serum lipid profile and levels of oxidative markers in the brain cortex and hippocampus tissues were evaluated. Results: The levels of malondialdehyde in the brain cortex and hippocampus in all the treated groups decreased significantly (p < 0.05). There was a significant increase in the total thiol concentration as well as catalase activity in treated rats in (M + AT), (M + C + ASA), (M + C + AT), (M + AT + ASA) and (M + C + AT + ASA) groups in cortex and hippocampus in comparison with the diabetic rats (p < 0.05). Also, the superoxide dismutase activity in all treated rats with medications was significantly increased compared to the diabetic rats (p < 0.05–0.01). Conclusion: Our findings showed that the combined use of high-dose aspirin, metformin, captopril and atorvastatin potentiated their antioxidant effects on the brain, and hence could potentially improve cognitive function with their neuroprotective effects on hippocampus.
Citation
Paseban, M., Mohebbati, R., Niazmand, S., Sathyapalan, T., & Sahebkar, A. (2019). Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in diabetes mellitus. Biomolecules, 9(4), 118. https://doi.org/10.3390/biom9040118
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 27, 2019 |
Online Publication Date | Mar 27, 2019 |
Publication Date | Apr 3, 2019 |
Deposit Date | Apr 3, 2019 |
Publicly Available Date | Apr 5, 2019 |
Journal | Biomolecules |
Electronic ISSN | 2218-273X |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 9 |
Issue | 4 |
Pages | 118 |
DOI | https://doi.org/10.3390/biom9040118 |
Keywords | Diabetes; Oxidative stress; Metformin; Captopril; Atorvastatin; Aspirin; Neuroprotective |
Public URL | https://hull-repository.worktribe.com/output/1543445 |
Publisher URL | https://www.mdpi.com/2218-273X/9/4/118 |
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Copyright Statement
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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