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Neural responses to facial expressions support the role of the amygdala in processing threat

Mattavelli, Giulia; Sormaz, Mladen; Flack, Tessa; Asghar, Aziz U. R.; Fan, Siyan; Frey, Julia; Manssuer, Luis; Usten, Deniz; Young, Andrew W.; Andrews, Timothy J.

Authors

Giulia Mattavelli

Mladen Sormaz

Tessa Flack

Aziz U. R. Asghar

Siyan Fan

Julia Frey

Luis Manssuer

Deniz Usten

Andrew W. Young

Timothy J. Andrews



Abstract

The amygdala is known to play an important role in the response to facial expressions that convey fear. However, it remains unclear whether the amygdala’s response to fear reflects its role in the interpretation of danger and threat, or whether it is to some extent activated by all facial expressions of emotion. Previous attempts to address this issue using neuroimaging have been confounded by differences in the use of control stimuli across studies. Here, we address this issue using a block design functional magnetic resonance imaging paradigm, in which we compared the response to face images posing expressions of fear, anger, happiness, disgust and sadness with a range of control conditions. The responses in the amygdala to different facial expressions were compared with the responses to a non-face condition (buildings), to mildly happy faces and to neutral faces. Results showed that only fear and anger elicited significantly greater responses compared with the control conditions involving faces. Overall, these findings are consistent with the role of the amygdala in processing threat, rather than in the processing of all facial expressions of emotion, and demonstrate the critical importance of the choice of comparison condition to the pattern of results.

Journal Article Type Article
Publication Date 2014-11
Journal Social Cognitive and Affective Neuroscience
Print ISSN 1749-5016
Electronic ISSN 1749-5016
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 9
Issue 11
Pages 1684-1689
APA6 Citation Mattavelli, G., Sormaz, M., Flack, T., Asghar, A. U. R., Fan, S., Frey, J., …Andrews, T. J. (2014). Neural responses to facial expressions support the role of the amygdala in processing threat. Social Cognitive and Affective Neuroscience, 9(11), 1684-1689. https://doi.org/10.1093/scan/nst162
DOI https://doi.org/10.1093/scan/nst162
Keywords Amygdala; Facial expressions; Emotion
Publisher URL https://academic.oup.com/scan/article/9/11/1684/1681410

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com





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