Mark Lucock
Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence
Lucock, Mark; Yates, Zoë; Martin, Charlotte; Choi, Jeong-Hwa; Beckett, Emma; Boyd, Lyndell; LeGras, Kathleen; Ng, Xiaowei; Skinner, Virginia; Wai, Ron; Kho, Jeremy; Roach, Paul; Veysey, Martin
Authors
Zoë Yates
Charlotte Martin
Jeong-Hwa Choi
Emma Beckett
Lyndell Boyd
Kathleen LeGras
Xiaowei Ng
Virginia Skinner
Ron Wai
Jeremy Kho
Paul Roach
Martin Veysey
Abstract
Purpose
The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively with one-carbon metabolism-dependent gene variants, and whether such a diet modifies blood homocysteine, a biochemical phenotype closely related to the phenomenon of methylation.
Methods
249 subjects were examined using selective fluorescence, PCR and food frequency questionnaire to determine homocysteine, nine methylation-related gene polymorphisms, dietary methionine, 5-methyltetrahydrofolate, vitamins B6 and B12.
Results
1). Both dietary methionine and 5-methyltetrahydrofolate intake are significantly associated with plasma homocysteine. 2). Dietary methionine is related to AP risk in 2R3R-TS wildtype subjects, while dietary B12 is similarly related to this phenotype in individuals heterozygous for C1420T-SHMT, A2756G-MS and 844ins68-CBS, and in those recessive for 2R3R-TS. 3). Dietary methionine has a marginal influence on plasma homocysteine level in C1420T-SHMT heterozygotes, while B6 exhibits the same effect on homocysteine in C776G-TCN2 homozygote recessive subjects. Natural 5-methyltetrahydrofolate intake is interesting: Wildtype A1298C-MTHFR, heterozygote C677T-MTHFR, wildtype A2756G-MS and recessive A66G-MSR individuals all show a significant reciprocal association with homocysteine. 4). Stepwise regression of all genotypes to predict risk for AP indicated A2756G-MS and A66G-MSR to be most relevant (p = 0.0176 and 0.0408 respectively). Results were corrected for age and gender.
Conclusion
A methylation diet influences methyl group synthesis in the regulation of blood homocysteine level, and is modulated by genetic interactions. Methylation-related nutrients also interact with key genes to modify risk of AP, a precursor of colorectal cancer. Independent of diet, two methylation-related genes (A2756G-MS and A66G-MSR) were directly associated with AP occurrence.
Citation
Lucock, M., Yates, Z., Martin, C., Choi, J.-H., Beckett, E., Boyd, L., LeGras, K., Ng, X., Skinner, V., Wai, R., Kho, J., Roach, P., & Veysey, M. (2015). Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence. Bba Clinical, 3, 107-112. https://doi.org/10.1016/j.bbacli.2014.11.005
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 29, 2014 |
Online Publication Date | Jan 5, 2015 |
Publication Date | 2015-06 |
Deposit Date | Apr 25, 2019 |
Publicly Available Date | Apr 26, 2019 |
Journal | BBA Clinical |
Print ISSN | 2214-6474 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 3 |
Pages | 107-112 |
DOI | https://doi.org/10.1016/j.bbacli.2014.11.005 |
Keywords | Adenomatous polyp; Folate; Methionine; Vitamin B12; Vitamin B6; Homocysteine; Colorectal cancer; Diet |
Public URL | https://hull-repository.worktribe.com/output/1647389 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S2214647414000312?via%3Dihub |
Contract Date | Apr 26, 2019 |
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
Copyright Statement
© 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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