Effects of curcumin on ion channels and pumps: A review

Tabeshpour, Jamshid; Banaeeyeh, Sara; Eisvand, Farhad; Sathyapalan, Thozhukat; Hashemzaei, Mahmoud; Sahebkar, Amirhossein

Abstract

Curcumin, an orange‐yellow lipophilic polyphenolic molecule, is the active component of Curcuma longa, which is extensively used as a spice in most of the Asian countries. This natural compound is able to interact with a large number of molecular structures like proteins, enzymes, lipids, DNA, RNA, transporter molecules, and ion channels. It has been reported to possess several biological effects such as antioxidant, anti‐inflammatory, wound healing, antimicrobial, anticancer, antiangiogenic, antimutagenic, and antiplatelet aggregation properties. These beneficial effects of curcumin are because of its extraordinary chemical interactions such as extensive hydrogen and covalent bonding, metal chelation, and so on. Therefore, the aim of this review was to outline the evidence in which curcumin could affect different types of ion channels and ion channel‐related diseases, and also to elucidate basic molecular mechanisms behind it.

Citation

Tabeshpour, J., Banaeeyeh, S., Eisvand, F., Sathyapalan, T., Hashemzaei, M., & Sahebkar, A. (2019). Effects of curcumin on ion channels and pumps: A review. IUBMB Life, 71(7), 812-820. https://doi.org/10.1002/iub.2054

• Journal Article Type: Review
• Acceptance Date: Apr 10, 2019
• Online Publication Date: Apr 25, 2019
• Publication Date: 2019-07
• Deposit Date: Apr 26, 2019
• Publicly Available Date: Apr 26, 2020
• Journal: IUBMB Life
• Print ISSN: 1521-6543
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 71
• Issue: 7
• Pages: 812-820
• DOI: https://doi.org/10.1002/iub.2054
• Keywords: Clinical Biochemistry; Genetics; Cell Biology; Biochemistry; Molecular Biology
• Public URL: https://hull-repository.worktribe.com/output/1649918
• Publisher URL: https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.2054
• Contract Date: Apr 29, 2019