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Relationship between B-vitamin biomarkers and dietary intake with apolipoprotein E є4 in Alzheimer’s disease

D’Cunha, Nathan M.; Roach, Paul D.; Naumovski, Nenad; Georgousopoulou, Ekavi N.; Boyd, Lyndell; Veysey, Martin; Sturm, Jonathan; O’Brien, Bill; Lucock, Mark; McKune, Andrew J.; Mellor, Duane D.

Authors

Nathan M. D’Cunha

Ekavi N. Georgousopoulou

Lyndell Boyd

Martin Veysey

Jonathan Sturm

Bill O’Brien

Mark Lucock

Andrew J. McKune

Duane D. Mellor

Paul D. Roach

Nenad Naumovski

Abstract

The potential for B-vitamins to reduce plasma homocysteine (Hcy) and reduce the risk of Alzheimer’s disease (AD) has been described previously. However, the role of Apolipoprotein E є4 (APOE4) in this relationship has not been adequately addressed. This case-control study explored APOE4 genotype in an Australian sample of 63 healthy individuals (female = 38; age = 76.9 ± 4.7 y) and 63 individuals with AD (female = 35, age = 77.1 ± 5.3 y). Findings revealed 55 of 126 participants expressed the APOE4 genotype with 37 of 126 having both AD and the APOE4 genotype. Analysis revealed an increased likelihood of AD when Hcy levels are >11.0 µmol/L (p = 0.012), cysteine levels were

Journal Article Type Article
Publication Date Apr 3, 2019
Journal Journal of Nutrition in Gerontology and Geriatrics
Print ISSN 2155-1197
Electronic ISSN 2155-1200
Publisher Taylor & Francis (Routledge)
Peer Reviewed Peer Reviewed
Volume 38
Issue 2
Pages 173-195
Institution Citation D’Cunha, N. M., Georgousopoulou, E. N., Boyd, L., Veysey, M., Sturm, J., O’Brien, B., …Naumovski, N. (2019). Relationship between B-vitamin biomarkers and dietary intake with apolipoprotein E є4 in Alzheimer’s disease. Journal of Nutrition in Gerontology and Geriatrics, 38(2), 173-195. https://doi.org/10.1080/21551197.2019.1590287
DOI https://doi.org/10.1080/21551197.2019.1590287
Keywords Aged; Aging; Alzheimer disease; Apolipoprotein E; Cysteine; Dementia; Elderly; Folate; Folic acid; Homocysteine; Nutritional vulnerability
Publisher URL https://www.tandfonline.com/doi/full/10.1080/21551197.2019.1590287
Additional Information Peer Review Statement: The publishing and review policy for this title is described in its Aims & Scope.; Aim & Scope: http://www.tandfonline....ope&journalCode=wjne21; Published: 2019-03-29