Relationship between B-vitamin biomarkers and dietary intake with apolipoprotein E є4 in Alzheimer’s disease

D’Cunha, Nathan M.; Georgousopoulou, Ekavi N.; Boyd, Lyndell; Veysey, Martin; Sturm, Jonathan; O’Brien, Bill; Lucock, Mark; McKune, Andrew J.; Mellor, Duane D.; Roach, Paul D.; Naumovski, Nenad

Abstract

The potential for B-vitamins to reduce plasma homocysteine (Hcy) and reduce the risk of Alzheimer’s disease (AD) has been described previously. However, the role of Apolipoprotein E є4 (APOE4) in this relationship has not been adequately addressed. This case-control study explored APOE4 genotype in an Australian sample of 63 healthy individuals (female = 38; age = 76.9 ± 4.7 y) and 63 individuals with AD (female = 35, age = 77.1 ± 5.3 y). Findings revealed 55 of 126 participants expressed the APOE4 genotype with 37 of 126 having both AD and the APOE4 genotype. Analysis revealed an increased likelihood of AD when Hcy levels are >11.0 µmol/L (p = 0.012), cysteine levels were

Citation

D’Cunha, N. M., Georgousopoulou, E. N., Boyd, L., Veysey, M., Sturm, J., O’Brien, B., …Naumovski, N. (2019). Relationship between B-vitamin biomarkers and dietary intake with apolipoprotein E є4 in Alzheimer’s disease. Journal of Nutrition in Gerontology and Geriatrics, 38(2), 173-195. https://doi.org/10.1080/21551197.2019.1590287

• Journal Article Type: Article
• Acceptance Date: Feb 21, 2019
• Online Publication Date: Mar 29, 2019
• Publication Date: Apr 3, 2019
• Deposit Date: Jun 3, 2019
• Publicly Available Date: Mar 30, 2020
• Journal: Journal of Nutrition in Gerontology and Geriatrics
• Print ISSN: 2155-1197
• Electronic ISSN: 2155-1200
• Publisher: Taylor & Francis (Routledge)
• Peer Reviewed: Peer Reviewed
• Volume: 38
• Issue: 2
• Pages: 173-195
• DOI: https://doi.org/10.1080/21551197.2019.1590287
• Keywords: Aged; Aging; Alzheimer disease; Apolipoprotein E; Cysteine; Dementia; Elderly; Folate; Folic acid; Homocysteine; Nutritional vulnerability
• Public URL: https://hull-repository.worktribe.com/output/1929502
• Publisher URL: https://www.tandfonline.com/doi/full/10.1080/21551197.2019.1590287
• Additional Information: Peer Review Statement: The publishing and review policy for this title is described in its Aims & Scope.; Aim & Scope: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=wjne21; Published: 2019-03-29