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Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Keshavarzi, Zakieh; Shakeri, Farzaneh; Barreto, George E.; Bibak, Bahram; Sathyapalan, Thozhukat; Sahebkar, Amirhossein


Zakieh Keshavarzi

Farzaneh Shakeri

George E. Barreto

Bahram Bibak

Thozhukat Sathyapalan

Amirhossein Sahebkar


Traumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI, fluid percussion injury, cold injury, weight drop impact acceleration injury, lateral fluid percussion, cortical impact injury, and blast injury. Studies with Actaea racemosa, Artemisia annua, Aframomum melegueta, Carthamus tinctorius, Cinnamomum zeylanicum, Crocus sativus, Cnidium monnieri, Curcuma longa, Gastrodia elata, Malva sylvestris, Da Chuanxiong Formula, Erigeron breviscapus, Panax ginseng, Salvia tomentosa, Satureja khuzistanica, Nigella sativa, Drynaria fortune, Dracaena cochinchinensis, Polygonum cuspidatum, Rosmarinus officinalis, Rheum tanguticum, Centella asiatica, and Curcuma zedoaria show a significant decrease in neuronal injury by different mechanisms such as increasing superoxide dismutase and catalase activities, suppressing nuclear factor kappa B (NF‐κB), interleukin 1 (IL‐1), glial fibrillary acidic protein, and IL‐6 expression. The aim of this study was to evaluate the neuroprotective effects of medicinal plants in central nervous system pathologies by reviewing the available literature.

Journal Article Type Article
Publication Date Aug 10, 2019
Journal BioFactors
Print ISSN 0951-6433
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 45
Issue 4
Pages 517-535
Institution Citation Keshavarzi, Z., Shakeri, F., Barreto, G. E., Bibak, B., Sathyapalan, T., & Sahebkar, A. (2019). Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited. BioFactors, 45(4), 517-535.
Keywords Clinical Biochemistry; Molecular Medicine; Biochemistry; General Medicine
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