Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Keshavarzi, Zakieh; Shakeri, Farzaneh; Barreto, George E.; Bibak, Bahram; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Abstract

Traumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI, fluid percussion injury, cold injury, weight drop impact acceleration injury, lateral fluid percussion, cortical impact injury, and blast injury. Studies with Actaea racemosa, Artemisia annua, Aframomum melegueta, Carthamus tinctorius, Cinnamomum zeylanicum, Crocus sativus, Cnidium monnieri, Curcuma longa, Gastrodia elata, Malva sylvestris, Da Chuanxiong Formula, Erigeron breviscapus, Panax ginseng, Salvia tomentosa, Satureja khuzistanica, Nigella sativa, Drynaria fortune, Dracaena cochinchinensis, Polygonum cuspidatum, Rosmarinus officinalis, Rheum tanguticum, Centella asiatica, and Curcuma zedoaria show a significant decrease in neuronal injury by different mechanisms such as increasing superoxide dismutase and catalase activities, suppressing nuclear factor kappa B (NF‐κB), interleukin 1 (IL‐1), glial fibrillary acidic protein, and IL‐6 expression. The aim of this study was to evaluate the neuroprotective effects of medicinal plants in central nervous system pathologies by reviewing the available literature.

Citation

Keshavarzi, Z., Shakeri, F., Barreto, G. E., Bibak, B., Sathyapalan, T., & Sahebkar, A. (2019). Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited. BioFactors, 45(4), 517-535. https://doi.org/10.1002/biof.1516

• Journal Article Type: Article
• Acceptance Date: Jun 3, 2019
• Online Publication Date: Jun 17, 2019
• Publication Date: Aug 10, 2019
• Deposit Date: Jun 18, 2019
• Publicly Available Date: Jun 19, 2019
• Journal: BioFactors
• Print ISSN: 0951-6433
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 45
• Issue: 4
• Pages: 517-535
• DOI: https://doi.org/10.1002/biof.1516
• Keywords: Brain; Medicinal plants; Signaling mechanisms; TBI; Trauma
• Public URL: https://hull-repository.worktribe.com/output/2004421
• Publisher URL: https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/biof.1516
• Contract Date: Jun 19, 2019