Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes
Yaribeygi, Habib; Yaribeygi, Alijan; Sathyapalan, Thozhukat; Sahebkar, Amirhossein
Diabetes mellitus is the most prevalent metabolic disorder contributing to significant morbidity and mortality in humans. Many preventative and therapeutic agents have been developed for normalizing glycemic profile in patients with diabetes. In addition to various pharmacologic strategies, many non-pharmacological agents have also been suggested to improve glycemic control in patients with diabetes. Trehalose is a naturally occurring disaccharide which is not synthesized in human but is widely used in food industries. Some studies have provided evidence indicating that it can potentially modulate glucose metabolism and help to stabilize glucose homeostasis in patients with diabetes. Studies have shown that trehalose can significantly modulate insulin sensitivity via at least 7 molecular pathways leading to better control of hyperglycemia. In the current study, we concluded about possible anti-hyperglycemic effects of trehalose suggesting trehalose as a potentially potent non-pharmacological agent for the management of diabetes.
|Journal Article Type||Article|
|Journal||Diabetes & Metabolic Syndrome: Clinical Research & Reviews|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Yaribeygi, H., Yaribeygi, A., Sathyapalan, T., & Sahebkar, A. (2019). Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13(3), 2214-2218. https://doi.org/10.1016/j.dsx.2019.05.023|
|Keywords||Internal Medicine; Endocrinology, Diabetes and Metabolism; General Medicine|
You might also like
Renin-Angiotensin System Overactivation in Type 2 Diabetes: A Risk for SARS-CoV-2 Infection?
The role of interleukin-18 in the development and progression of atherosclerosis