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Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes

Yaribeygi, Habib; Yaribeygi, Alijan; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

Authors

Habib Yaribeygi

Alijan Yaribeygi

Thozhukat Sathyapalan

Amirhossein Sahebkar



Abstract

Diabetes mellitus is the most prevalent metabolic disorder contributing to significant morbidity and mortality in humans. Many preventative and therapeutic agents have been developed for normalizing glycemic profile in patients with diabetes. In addition to various pharmacologic strategies, many non-pharmacological agents have also been suggested to improve glycemic control in patients with diabetes. Trehalose is a naturally occurring disaccharide which is not synthesized in human but is widely used in food industries. Some studies have provided evidence indicating that it can potentially modulate glucose metabolism and help to stabilize glucose homeostasis in patients with diabetes. Studies have shown that trehalose can significantly modulate insulin sensitivity via at least 7 molecular pathways leading to better control of hyperglycemia. In the current study, we concluded about possible anti-hyperglycemic effects of trehalose suggesting trehalose as a potentially potent non-pharmacological agent for the management of diabetes.

Journal Article Type Article
Publication Date 2019-05
Journal Diabetes & Metabolic Syndrome: Clinical Research & Reviews
Print ISSN 1871-4021
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 13
Issue 3
Pages 2214-2218
APA6 Citation Yaribeygi, H., Yaribeygi, A., Sathyapalan, T., & Sahebkar, A. (2019). Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13(3), 2214-2218. https://doi.org/10.1016/j.dsx.2019.05.023
DOI https://doi.org/10.1016/j.dsx.2019.05.023
Keywords Internal Medicine; Endocrinology, Diabetes and Metabolism; General Medicine
Publisher URL https://www.sciencedirect.com/science/article/pii/S1871402119302784?via%3Dihub

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