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A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A

Bailey, Christopher S.; Zarins-Tutt, Joseph S.; Agbo, Matthias; Gao, Hong; Diego-Taboada, Alberto; Gan, Maoluo; Hamed, Refaat B.; Abraham, Emily R.; Mackenzie, Grahame; Evans, P. Andrew; Goss, Rebecca J. M.


Christopher S. Bailey

Joseph S. Zarins-Tutt

Matthias Agbo

Hong Gao

Alberto Diego-Taboada

Maoluo Gan

Refaat B. Hamed

Emily R. Abraham

P. Andrew Evans

Rebecca J. M. Goss


The photoprotection and isolation of marinomycin A using sporopollenin exine capsules (SpECs) derived from the spores of the plant Lycopodium clavatum is described. The marinomycins have a particularly short half-life in natural light, which severely impacts their potential biological utility given that they display potent antibiotic and anticancer activity. The SpEC encapsulation of the marinomycin A dramatically increases the half-life of the polyene macrodiolide to the direct exposure to UV radiation by several orders of magnitude, thereby making this a potentially useful strategy for other light sensitive bioactive agents. In addition, we report that the SpECs can also be used to selectively extract culture broths that contain the marinomycins, which provides a significantly higher recovery than with conventional XAD resins and provides concomitant photoprotection.


Bailey, C. S., Zarins-Tutt, J. S., Agbo, M., Gao, H., Diego-Taboada, A., Gan, M., …Goss, R. J. M. (2019). A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A. Chemical science, 10(32), 7549-7553.

Journal Article Type Article
Acceptance Date May 20, 2019
Online Publication Date Aug 14, 2019
Publication Date Aug 14, 2019
Deposit Date Sep 9, 2019
Publicly Available Date Sep 9, 2019
Journal Chemical Science
Print ISSN 2041-6520
Electronic ISSN 2041-6539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 10
Issue 32
Pages 7549-7553
Keywords General Chemistry
Public URL
Publisher URL!divAbstract


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