Jun An Fang
Molecular Tweezers-like Calix[4]arene Based Alkaline Earth Metal Cation (Ca2+, Sr2+, and Ba2+) Chemosensor and Its Imaging in Living Cells and Zebrafish
Fang, Jun An; Zhao, Jiang Lin; Liao, Xian; Zeng, Xi; Chen, Kai; Wei, Xiao Yuan; Su, Shao Bo; Luo, Qing Ying; Redshaw, Carl; Jin, Zongwen
Authors
Jiang Lin Zhao
Xian Liao
Xi Zeng
Kai Chen
Xiao Yuan Wei
Shao Bo Su
Qing Ying Luo
Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry
Zongwen Jin
Abstract
Although alkaline earth metal cations play an important role in our daily life, little attention has been paid to the field of fast quantitative analysis of their content due to a lack of satisfactory precision and a fast and convenient means of detection. In this study, we have designed a set of molecular tweezers based on the calix[4]arene chemosensor L, which was found to exhibit high selectivity and sensitivity toward Ca2+, Sr2+, and Ba2+ (by UV-vis and fluorescence methods) with low detection limits of the order of 10-7 to 10-8 M and high association constants (of the order of 106). More significantly, sensor L not only can recognize Ca2+, Sr2+, and Ba2+ but also can further discriminate between these three cations via the differing red shifts in their UV-vis spectra (560 nm for L·Ca2+, 570 nm for L·Sr2+, and 580 nm for L·Ba2+ complex) which is attributed to their different atomic radii. A rare synergistic effect for the recognition mechanism has been demonstrated by 1H NMR spectroscopic titration. Sensor L constructed a high shielding field by the cooperation of Tris with alkaline earth metal ion after complex. Additionally, the presence of acetoxymethyl group in sensor L results in enhancement of cell permeability, and as a consequence, sensor L exhibited excellent sensing and imaging (in vivo) in living cells and in zebrafish.
Citation
Fang, J. A., Zhao, J. L., Liao, X., Zeng, X., Chen, K., Wei, X. Y., …Jin, Z. (2019). Molecular Tweezers-like Calix[4]arene Based Alkaline Earth Metal Cation (Ca2+, Sr2+, and Ba2+) Chemosensor and Its Imaging in Living Cells and Zebrafish. Inorganic chemistry, 58(21), 14720-14727. https://doi.org/10.1021/acs.inorgchem.9b02364
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 1, 2019 |
Online Publication Date | Oct 15, 2019 |
Publication Date | Nov 4, 2019 |
Deposit Date | Nov 8, 2019 |
Publicly Available Date | Oct 16, 2020 |
Journal | Inorganic Chemistry |
Print ISSN | 0020-1669 |
Electronic ISSN | 1520-510X |
Publisher | American Chemical Society |
Peer Reviewed | Peer Reviewed |
Volume | 58 |
Issue | 21 |
Pages | 14720-14727 |
DOI | https://doi.org/10.1021/acs.inorgchem.9b02364 |
Keywords | Calix[4]arene; Chemosensor; Alkaline earth metal ions; Synergistic effect; Molecular tweezers |
Public URL | https://hull-repository.worktribe.com/output/2946779 |
Publisher URL | https://pubs.acs.org/doi/10.1021/acs.inorgchem.9b02364 |
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©2019 University of Hull
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