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Molecular Tweezers-like Calix[4]arene Based Alkaline Earth Metal Cation (Ca2+, Sr2+, and Ba2+) Chemosensor and Its Imaging in Living Cells and Zebrafish

Fang, Jun An; Zhao, Jiang Lin; Liao, Xian; Zeng, Xi; Chen, Kai; Wei, Xiao Yuan; Su, Shao Bo; Luo, Qing Ying; Redshaw, Carl; Jin, Zongwen

Authors

Jun An Fang

Jiang Lin Zhao

Xian Liao

Xi Zeng

Kai Chen

Xiao Yuan Wei

Shao Bo Su

Qing Ying Luo

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Professor Carl Redshaw C.Redshaw@hull.ac.uk
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry

Zongwen Jin



Abstract

Although alkaline earth metal cations play an important role in our daily life, little attention has been paid to the field of fast quantitative analysis of their content due to a lack of satisfactory precision and a fast and convenient means of detection. In this study, we have designed a set of molecular tweezers based on the calix[4]arene chemosensor L, which was found to exhibit high selectivity and sensitivity toward Ca2+, Sr2+, and Ba2+ (by UV-vis and fluorescence methods) with low detection limits of the order of 10-7 to 10-8 M and high association constants (of the order of 106). More significantly, sensor L not only can recognize Ca2+, Sr2+, and Ba2+ but also can further discriminate between these three cations via the differing red shifts in their UV-vis spectra (560 nm for L·Ca2+, 570 nm for L·Sr2+, and 580 nm for L·Ba2+ complex) which is attributed to their different atomic radii. A rare synergistic effect for the recognition mechanism has been demonstrated by 1H NMR spectroscopic titration. Sensor L constructed a high shielding field by the cooperation of Tris with alkaline earth metal ion after complex. Additionally, the presence of acetoxymethyl group in sensor L results in enhancement of cell permeability, and as a consequence, sensor L exhibited excellent sensing and imaging (in vivo) in living cells and in zebrafish.

Citation

Fang, J. A., Zhao, J. L., Liao, X., Zeng, X., Chen, K., Wei, X. Y., …Jin, Z. (2019). Molecular Tweezers-like Calix[4]arene Based Alkaline Earth Metal Cation (Ca2+, Sr2+, and Ba2+) Chemosensor and Its Imaging in Living Cells and Zebrafish. Inorganic chemistry, 58(21), 14720-14727. https://doi.org/10.1021/acs.inorgchem.9b02364

Journal Article Type Article
Acceptance Date Oct 1, 2019
Online Publication Date Oct 15, 2019
Publication Date Nov 4, 2019
Deposit Date Nov 8, 2019
Publicly Available Date Oct 16, 2020
Journal Inorganic Chemistry
Print ISSN 0020-1669
Electronic ISSN 1520-510X
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 58
Issue 21
Pages 14720-14727
DOI https://doi.org/10.1021/acs.inorgchem.9b02364
Keywords Calix[4]arene; Chemosensor; Alkaline earth metal ions; Synergistic effect; Molecular tweezers
Public URL https://hull-repository.worktribe.com/output/2946779
Publisher URL https://pubs.acs.org/doi/10.1021/acs.inorgchem.9b02364

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