Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review

Yaribeygi, Habib; Sathyapalan, Thozhukat; Maleki, Mina; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

Abstract

Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are a relatively newer class of anti-hyperglycemic medications that reduce blood glucose by inhibition of renal glucose re-uptake, thereby increasing urinary glucose excretion. Although glycosuria is the primary mechanism of action of these agents, there is some evidence suggesting they can reduce insulin resistance and induce peripheral insulin sensitivity. Identifying the molecular mechanisms by which these medications improve glucose homeostasis can help us to develop newer forms of SGLT2i with lesser side effects. We have reviewed the molecular mechanisms and signaling pathways by which SGLT2i therapy improve insulin sensitivity and ameliorates insulin resistance.

Citation

Yaribeygi, H., Sathyapalan, T., Maleki, M., Jamialahmadi, T., & Sahebkar, A. (2020). Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review. Life Sciences, 240, Article 117090. https://doi.org/10.1016/j.lfs.2019.117090

• Journal Article Type: Review
• Acceptance Date: Nov 18, 2019
• Online Publication Date: Nov 22, 2019
• Publication Date: 2020-01
• Deposit Date: Nov 26, 2019
• Publicly Available Date: Nov 23, 2020
• Journal: Life Sciences
• Print ISSN: 0024-3205
• Electronic ISSN: 1879-0631
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 240
• Article Number: 117090
• DOI: https://doi.org/10.1016/j.lfs.2019.117090
• Keywords: Sodium-glucose co-transporter-2 inhibitors; Insulin sensitivity; Insulin resistance; Diabetes mellitus; Oxidative stress; Inflammatory response
• Public URL: https://hull-repository.worktribe.com/output/3253401
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0024320519310173?via%3Dihub
• Additional Information: This article is maintained by: Elsevier; Article Title: Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review; Journal Title: Life Sciences; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.lfs.2019.117090; Content Type: article; Copyright: © 2019 Published by Elsevier Inc.